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Newfactan 120mg medicine has the main ingredient is Bovine lung surfactant 120mg. This is an inhaled medication, used in the treatment of respiratory distress syndrome in infants.
1. Newfactan drug use
Newfactan belongs to the group of drugs acting on the respiratory tract, with the main ingredient being Bovine lung surfactant 120mg. Bovine lung surfactant has been shown to improve ventilation including respiratory pressure (maximum), gas exchange rate, and exhaled oxygen concentration to maintain arterial oxygen pressure and physiological blood pH. .
Newfactan drug is prepared in the form of lyophilized powder mixed with suspension for use through the alveoli, packed in vials of 1g. Newfactan is indicated for the treatment of neonatal respiratory distress syndrome.
2. How to use and dose Newfactan
Newfactan is mixed with physiological saline (120mg/4ml) into a suspension and put through the trachea at a dose of 120mg/kg body weight. In order for the drug to evenly distribute the entire lung field, it is necessary to introduce the drug into the body 4-5 times, changing the body position each time.
It is necessary to ensure that the percutaneous arterial oxygen pressure is 80mmHg or more during each injection of Newfactan, and the child is still breathing with 100% oxygen.
The first dose is within 8 hours after birth and depending on the condition, the dose can be increased by 60 - 120mg/kg body weight.
Although, Newfactan overdose has not been recorded, but the use of the drug should be followed the indications. In case of overdose, the drug should be stopped immediately and the child should be cared for with appropriate measures.
3. Newfactan drug side effects
Newfactan can cause some unwanted side effects such as:
Increased risk of pulmonary hemorrhage, especially premature babies. Transient bradycardia endotracheal tube obstruction (due to mucus) Decreased brain electrical activity It is necessary to immediately report to the doctor any unwanted side effects that children experience after taking Newfactan .
4. Some notes when using Newfactan
Do not use Newfactan in people with hypersensitivity to the ingredients of the drug. Children with a family history should be cautious when using Newfactan. If after the first use of Newfactan does not see any effect, consider the child's condition with another disease. Immediately after administration of Newfactan, it is necessary to wait for a long period of respiratory phase (from 0.7 - 1 second) to ensure suitable ventilation conditions, reduce the frequency of gas exchange (30 - 40 times/min). and certain pressure. After treatment with Newfactan and improvement in arterial oxygen pressure, ventilation conditions can be altered by reducing the respiratory oxygen concentration and then adjusting the pressure, inspiratory phase time, and gas exchange rate. The efficacy of Newfactan may be reduced in infants with respiratory failure whose left or right shunt changes due to the ductus arteriosus at birth, and increased shunt volume may result in pulmonary congestion or convalescent heart failure. Use caution when using Newfactan to limit damage to the ductus arteriosus. Treatment of ductus arteriosus closure in preterm premature infants immediately after drug administration. An additional dose of Newfactan should be used only in cases where the respiratory oxygen concentration and mean alveolar pressure cannot be reduced, chest x-ray shows a mesh and granular shadow. When introducing Newfactan into the body, care should be taken to avoid infection. Healthcare professionals should follow instructions when administering the resulting Newfactan solution to the syringe with the needle. Connect the syringe to a sterile small tube and insert the drug into the trachea through the tracheal tube. Note, do not put Newfactan into the blood vessels. The medical staff should gently disperse 4ml of physiological saline into the drug mixture with a catheter needle so as not to create air bubbles on the surface. Gently shake the Newfactan vial to obtain a homogeneous suspension. In the absence of physiological saline, an inferior suspension can be obtained. Use Newfactan suspension only after it has been warmed to body temperature. Before taking Newfactan, it is necessary to clear the sputum and amniotic fluid in the trachea. Immediately after reconstitution, the suspension should be used immediately and do not use the remainder because the drug may have been contaminated. Newfactan is in the form of lyophilized powder and can be dissolved into a powder before use, but must ensure that it does not affect the effectiveness of the drug. The use of Newfactan is to improve ventilation in neonates with respiratory distress syndrome. The drug has the effect of increasing respiratory pressure (maximum), gas exchange rate, oxygen concentration in exhaled air to maintain arterial oxygen pressure and physiological blood pH.
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