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Naspalun drug has the main ingredients are cefoperazone and sulbactam. This is an antibiotic made in the form of lyophilized powder for injection, often used in cases of bacterial infections. The following article will help you better understand the uses and other related information of Naspalun.
1. What is Naspalun?
What is Naspalun drug? The composition of Naspalun includes 500mg of cefoperazone and 500mg of sulbactam. In particular, cefoperazone is a 3rd generation cephalosporin antibiotic. It has the ability to kill bacteria through inhibition of mucopeptide synthesis on bacterial cell walls. However, over time, bacteria tend to become resistant to antibiotics through the production of beta-lactamase enzymes, which destroy beta-lactam antibiotics, including cefoperazone. Therefore, to avoid this destruction, it is common to combine penicillins or cephalosporins with beta lactamase inhibitors. Sulbactam is one of them.
Some strains of bacteria sensitive to cefoperazone and sulbactam are:
Haemophilus influenzae Bacteroides spp. Staphylococcus spp. Staphylococcus aureus Streptococcus pneumoniae Escherichia coli Klebsiella spp. Enterobacter spp. With the above mechanism, Naspalun is often indicated for the treatment of infections caused by susceptible strains of gram-positive and gram-negative bacteria in pathologies such as:
Respiratory tract infections (including upper respiratory tract and respiratory tract infections). Lower) Urinary tract infection, peritonitis Cholecystitis Intra-abdominal infection Meningitis Dermatitis
2. Dosage and how to use Naspalun
Naspalun can be used intravenously or intramuscularly. Medicines need to be mixed before use. Common solvents used to prepare Naspalun include: distilled water for injection, 5% dextrose solution, 0.9% sodium chloride.
The recommended adult dose of Naspalun is as follows:
If the infection is mild to moderate: 1 - 2 g of cefoperazone (corresponding to 2 - 4 vials of Naspalun), repeat every 12 hours. For severe infections: 2 - 4 g of cefoperazone (corresponding to 4 - 8 vials of Naspalun), administered every 12 hours. The dose of Naspalun in children is usually 25-100mg (Cefoperazon)/kg, repeated every 12 hours.
3. Precautions while taking Naspalun
Patients taking Naspalun should be aware of the following:
History of allergy to beta-lactam antibiotics such as penicillin or other cephalosporins should be considered, because of the potential for cross-allergic reactions between these groups. Allergies can lead to hypersensitivity reactions, more severe can be anaphylaxis, which can be life-threatening. In the body, Naspalun is eliminated mainly through the liver, specifically through bile. Therefore, in patients with liver disease, a dose reduction from the recommended dose should be considered. When patients are treated with Naspalun for a long time, they will face a disorder of beneficial bacteria in the digestive tract leading to side effects such as diarrhea, abdominal pain, loss of appetite,... Although there are not many studies, the drug Naspalun can still be prescribed for infants. However, the dose and duration of treatment for children need to be weighed by the doctor between the benefits and the risks.
4. Naspalun drug interactions
If you drink alcohol within 72 hours of using Naspalun, patients may experience an interaction reaction with common manifestations such as: flushing, sweating, heart palpitations, nervousness, headache. , nausea,...
Combining Naspalun with aminoglycosides has the potential to increase nephrotoxicity and cause synergistic antibacterial effects on some strains of Gram-negative bacteria. In addition, this combination also causes physical incompatibility. Therefore, in case of necessity, they must be used within a certain period of time.
Concomitant use of Naspalun with heparin or warfarin may increase the risk of bleeding.
Naspalun drug has the main ingredients are cefoperazone and sulbactam. This is an antibiotic made in the form of lyophilized powder for injection, often used in cases of bacterial infections. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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