This is an automatically translated article.
Naligram drug belongs to the group of parasitic drugs, anti-infectives. Naligram medicine has the main ingredient Nalidixic acid is indicated in the treatment of gram-negative infections of the lower urinary tract. However, the drug can cause some unwanted side effects, so before using Naligram, patients need to learn carefully and comply with the indications.
1. Mechanism of action of the drug Naligram
What is Naligram? Naligram drug contains nalidixic acid which belongs to the 1st generation quinolone antibiotic group which is also a typical substance of this group of drugs.
Naligram when absorbed into the body is rapidly and completely absorbed from the gastrointestinal tract. After oral administration of 1 gram of the drug, the maximum plasma concentration of 20 to 50 mcg/mL is reached within 2 hours. The drug is partially metabolised to hydroxy nalidixic acid, which has antibacterial activity.
Naligram is excreted unchanged in the urine, and is eliminated within 24 hours.
2. Indications and contraindications of Naligram
Naligram is indicated in the treatment of uncomplicated lower urinary tract gram-negative infections caused by major strains of bacteria E Coli, Enterobacter sp.... To reduce drug resistance, patients should test for susceptibility. of the drug before and during treatment to consider whether to use the drug or adjust the dose to suit the subject.
Cases of quinolone antibiotics including nalidixic acid have been associated with serious adverse reactions and uncomplicated urinary tract infections in some patients that resolved spontaneously. Therefore, Naligram should only be used in cases where the patient has no other alternative treatment options.
However, Naligram is also contraindicated in the following cases:
Patients with hypersensitivity to the components of the drug Patients with deficiency of the enzyme G6P dehydrogenase People with a history of epilepsy, central nervous system disorders , convulsions , cerebrovascular obstruction Children under 3 months of age Patient is being treated with chemotherapy for spinal cancer such as melphalan, as it can cause ulcerative colitis bleeding or bowel necrosis.
3. Dosage and how to use Naligram
Naligram is used in the morning and afternoon. The recommended adult dosage is 2 capsules 4 times a day. As for children, the dose of Naligram is 50mg/kg/day.
Note: The above recommended therapeutic dose for Naligram is for reference only. Therefore, before using Naligram, the patient should be prescribed by a doctor.
If you miss a dose of Naligram, use the missed dose as soon as you remember. However, if the interval between the missed dose of Naligram and the next dose is too close, skip the missed dose. Patients should not double the dose of Naligram, because it can cause an overdose. To overcome the situation of missing a dose of Naligram, patients can set an alarm or ask a loved one to remind them.
In case of accidentally using Naligram drug in excess of prescribed and showing some unwanted signs, it is necessary to take the patient to the emergency room immediately.
4. Unwanted side effects when using Naligram drug
Naligram can cause some unwanted side effects during treatment. However, with each case Naligram can occur in varying degrees from mild to severe.
Some common side effects caused by Naligram include: headache, nausea and vomiting, diarrhea, blurred vision, double vision, non-standard color vision, light poisoning reactions... These side effects may occur at the start of treatment or after an increase in the dose of Naligram . And usually the side effects from Naligram can be transient or subside over time.
However, in some cases Naligram can cause serious unwanted side effects with rare reactions. These reactions may appear within minutes of using Naligram or may be longer within a few days. When serious side effects appear such as: increased intracranial pressure, urticaria, itching, contrast, confusion, hallucinations, nightmares, anaphylactic reactions, angioedema... the patient should stop using the drug. Naligram and needs immediate medical attention.
5. Some notes in the process of using Naligram drug
For pregnant and lactating women, caution should be exercised when using Naligram. Patients should consult a doctor and carefully analyze the benefits and risks before using the drug. Naligram may change how it works as well as increase its side effects. Therefore, in order to avoid the situation, the patient should provide the doctor with a list of previously used drugs including prescription drugs, non-prescription drugs, herbs... Above is important information about Naligram drug, Patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
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