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Domperidone is an effective antiemetic. There are many different products containing this active ingredient, one of which is the drug Motidoperid 10 from Tipharco Pharmaceutical Joint Stock Company.
1. What is a brand-name drug Motidopiride?
Motidopiride is a preparation that acts on the gastrointestinal tract with the main active ingredient Domperidone (in the form of Domperidone maleate) with a concentration of 10mg. Motidopiride is manufactured by Tipharco Pharmaceutical Joint Stock Company, registered for circulation in Vietnam with the registration number VD-26266-17.Ingredients in Motidoperid:
Main ingredients: Domperidone (in the form of Domperidone maleate) 10mg; Some excipients are just enough for 1 tablet. Motidoperid is prepared in the form of tablets for oral use, packed in each box of 10 blisters x 10 tablets or 10 blisters (Alu/PVC) x 10 tablets.
2. What are the effects of Motidopiride?
The active ingredient Domperidone in Motidoperid is a Dopamine antagonist and has similar effects to another antiemetic, Metoclopramide hydrochloride. Domperidone has almost no effect on Dopamine receptors in the brain, so Motidopiride does not affect the mental and neurological function of patients. The mechanism of action of Domperidone is to stimulate gastrointestinal motility, increase sphincter tone as well as the expansion amplitude of the pyloric sphincter after meals, but this active substance does not affect the excretion process. of the stomach. Given these effects of domperidone, motidoperidone is used for the symptomatic treatment of acute nausea and vomiting, including vomiting associated with the use of levodopa or bromocriptine in patients with Parkinson's disease.Domperidone is absorbed mainly from the gastrointestinal tract, however, the oral bioavailability of Motidoperidone is quite low (only about 14% when the patient takes it on an empty stomach) because the drug is first metabolised in the liver and partly metabolized in the mucosa. intestinal mucosa. Besides the oral form such as Motidoperidone, Domperidone is also used by rectal or intramuscular injection.
After absorption, approximately 92-93% of a dose of Domperidone is bound to plasma proteins. Motidopiride virtually does not cross the blood-brain barrier. Motidoroid is rapidly and extensively metabolized via hydroxylation and oxidative N-alkyl reduction.
Domperidone in the drug Motidopiride is excreted in the feces and urine, mainly in the form of metabolites. According to the study, approximately 30% of a dose of Motidoperid is excreted in the urine in 24 hours (only 0.4% is in the initial form) and 66% is excreted in the feces during a period of 4 days (about 10% is the parent form). .
3. Indications, contraindications of Motidoperid
Motidoperid products are mainly indicated in the treatment of nausea, vomiting, loss of appetite, indigestion, bloating or belching, heartburn. In addition, Motidopiride is also indicated for the treatment of a number of age-dependent diseases as follows:
Adults: Motidopiride is used in the treatment of chronic gastritis, gastric prolapse, gastroesophageal reflux or gastroesophageal reflux disease. supportive treatment of symptoms after gastrectomy or for patients taking anti-cancer drugs or Levodopa; Children: Motidopiride products are used to treat cyclic vomiting, upper respiratory infections or in children being treated with anti-cancer drugs. Contraindications of Motidoperidone:
Patients with hypersensitivity/allergy to Domperidone or any substance contained in the drug; The patient is in the state of gastrointestinal bleeding, mechanical intestinal obstruction or intestinal perforation; Motidopiride should not be used in patients with prolactin-secreting pituitary adenomas.
4. Dosage of Motidoroid
The recommended dose of Motidopiride in the treatment of nausea and vomiting of different causes depends on age:
Adults: 1 to 2 Motidopiride 10mg tablets, taken every 4-8 hours; Children: Domperidone dose is 0.2-0.4mg/kg/time, taken every 4-8 hours. Dosage of Motidoperid used in symptoms of dyspepsia:
Adults: Take 1 to 2 Motidoperid 10 tablets each time, 3 times a day before meals and add 1-2 Motidopiride 10 tablets in the evening before sleeping; The duration of treatment of dyspepsia with the drug Motidoperid should not exceed 12 weeks; Motidopiride products are not recommended for use in the prevention of postoperative nausea and vomiting.
5. Motidoroid side effects
Some of Motidoroid's drug side effects include:
Headache, mental tension or drowsiness; Allergic manifestations such as skin rash, skin itching or transient allergic reactions; Lactation, male gynecomastia; Enlarged breasts accompanied by pain; Dry mouth, thirst; Abdominal muscle cramps; Diarrhea . This is not a complete list of all possible side effects. During use, there may be other side effects that have not been mentioned or studied. Therefore, if you notice any other abnormality that may be related to Motidoperid, the patient should promptly consult a doctor or pharmacist.
6. Motidoroid drug interactions
Motidopiride inhibits the CYP3A4 enzyme system, so it may affect the active ingredients of other drugs after concomitant use, including:
Ketoconazole; Bromocriptine; Opioid pain relievers; Muscarinic muscle relaxants; H2 antihistamines such as Cimetidine, Famotidine, Nizatidine or Ranitidine; Lithium.
7. Precautions when using Motidoperid
Use caution when using Motidopiride in patients with severe renal impairment; Motidopiride should not be used in patients with severe hepatic impairment.
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