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Mosad MT 5mg is a gastrointestinal drug with the ingredient mosapride citrate (in the form of Mosapride citrate dihydrate) 5mg to help treat symptoms of stomach effectively. Let's learn about the effects and effective use of Mosad MT5 in the following article.1. What is Mosad MT 5mg?
Mosad MT5 contains the active ingredient Mosapride, which is available as a 5mg tablet, which is used to prevent acid secretion in the stomach (mainly used to prevent ulcers caused by NSAID pain relievers). This medication can cause uterine contractions and is also sometimes used to induce labor and terminate pregnancy. Mosapride is a drug belonging to the group of digestive regulators, anti-flatulence and anti-inflammatory drugs. It is a 5 HT4 receptor agonist as well as a 5 HT3 receptor antagonist in the myocardium. Enterochromaffin cells in the lining of the gastrointestinal tract produce and release serotonin in response to stimuli (chemical or mechanical stimuli). Serotonin enhances peristalsis by stimulating sensory neurons in the muscle plexus. Stimulation of the 5 HT4 receptor will increase Acetylcholine release. Mosapride's metabolite induces 5 HT3 receptor antagonism and blocks inhibitory conduction in the myocardium. All of these lead to increased esophageal peristalsis, decreased esophageal sphincter tone, and increased intestinal contractility.It works by increasing the concentration of a certain natural chemical that increases the movement of stomach muscles and improves gastric emptying, helping to move food from the stomach to the intestines more quickly.
Mosad MT 5mg is rapidly absorbed into the gastrointestinal tract after oral administration, peak drug concentrations in the gastrointestinal tract, partly in the liver and partly in the kidneys.
Besides, Mosad MT5 drug, after being absorbed, will distribute in plasma at high concentrations, not distributed to the brain. Healthy people take the drug on an empty stomach, the absorption of the drug is faster. Plasma drug concentrations peak after 0.5 hours. Mosapride binds to 99% of plasma proteins.
CYP3A4 enzyme of cytochrome P450 helps Mosaprid to be metabolized in the liver, giving the main metabolite des - 4 - fluorobenzyl - mosapride
Elimination of Mosad MT5 in urine is collected 48 hours after taking the drug, 0.1% is is excreted as the unchanged compound and 7.0% is excreted as the major metabolite (compound des-4-fluorobenzyl). (Healthy adults, single dose of 5mg mosapride on an empty stomach).
2. What are the uses of Mosad MT5?
2.1. Indications of the drug Mosad MT5
Mosad MT5 is indicated for use in the following conditions:Gastroesophageal reflux disease: This medication is used to treat severe heartburn, acidity, indigestion and stomach pain associated with reflux. backflow of bile or stomach acid into the food pipe. Gastroparesis: This medication is used to treat very slow movement of food from the stomach leading to slow emptying. Support before X-ray examination with Barium enema: This drug is used together with oral gastrointestinal lavage solution as an adjunct prior to X-ray examination with Barium enema.
2.2. Contraindications of Mosad MT5
Mosad MT5 is contraindicated in the following cases:Allergies: This drug is not recommended for use in patients who are allergic to Mosapride or any other ingredient in the formulation. Gastrointestinal bleeding: This drug is not recommended for use in patients with bleeding inside the stomach and intestines. This can be attributed to a variety of reasons including a ruptured intestine (gastrointestinal perforation). Mechanical Intestinal Obstruction: This drug is not recommended for use in patients with intestinal obstruction or obstruction due to the increased risk of worsening of the patient's condition. Have a bleeding disorder. Have a bacterial infection or other inflammatory conditions. Have metabolic cardiovascular disease. Anemia. Have diabetes. Have any serious liver/kidney disease. Women who are pregnant or breastfeeding. Concomitant use with Ketoconazole, Itraconazole, Miconazole, Fluconazole, Erythromycin, Clarithromycin, Troleandomycin and Ritonavir. Patients who already have a prolonged QT interval, who are at risk of QT prolongation, such as from hypokalemia or magnesium deficiency, or when treated with other drugs that may increase the QT interval.
2.3. Side effects of Mosad MT5
Some unwanted effects of Mosad MT5 such as:Common side effects: Flatulence, dry mouth, diarrhea. Eat well. Increased liver enzymes, showing jaundice, yellow eyes. Headache, dizziness, dizziness. Nausea. Change in white blood cell count. Triglycerides increase. Uncommon side effects: Nausea. Transient headache. Rare side effects: Hypersensitivity skin reactions such as pruritus, erythema. Central nervous system effects are typically epileptic seizures. Irregular heartbeat. Interruption of the menstrual cycle. Endocrine: Gynecomastia in men, lactation. Urinating many times.
2.4. Precautions while using Mosad MT5
Mosad MT5 should be used with caution in the following cases:Pregnancy and lactation: Mosad MT5 is not recommended for use by pregnant or lactating women unless the use of the drug is absolutely necessary. set. All risks and benefits of taking Mosad MT5 should be discussed with your doctor before taking. Use in the elderly: This drug should be used with extreme caution in elderly patients over 65 years of age due to the risk of side effects. In some cases, it may be necessary to adjust the appropriate dose or replace with another drug suitable for the patient's condition but still must be based on the clinical situation. Stomach or intestinal bleeding: Inform your doctor of any signs of stomach bleeding such as blood in the stool, black or coffee-colored stools to the doctor immediately. This medicine should not be used if there are obvious signs or even suspected bleeding. Mechanical Intestinal Obstruction: Report any incidence indicating an intestinal obstruction such as severe flatulence, nausea, vomiting, severe abdominal cramps, constipation, etc. to the doctor. The use of this drug is not recommended in such cases. Other medications: Mosad MT5 can interact with many other medications and can cause serious side effects. Therefore, you should inform your doctor about all your current medications including any herbs and supplements before starting treatment with this medicine. Cardiovascular effects: This drug has been reported to cause serious side effects on the heart and blood vessels. Extreme caution should be exercised when using this medicine because these side effects can be fatal. Special attention is needed if you have pre-existing heart disease. In some cases, it may be necessary to adjust the appropriate dose or replace with another drug suitable for the patient's condition but still must be based on the clinical situation. Liver disease: Mosad MT5 should be used with caution in patients with liver disease due to the increased risk of serious side effects. Liver function should be closely monitored while taking this drug. In certain cases, it may be necessary to change the dose or use another medicine to replace it. Kidney disease: This drug should be used with caution in patients with kidney disease due to the increased risk of serious side effects. Renal function should be closely monitored by monitoring for symptoms or by blood tests while taking this medicine. In some cases, it may be necessary to adjust the appropriate dose or replace with another drug suitable for the patient's condition but still must be based on the clinical situation. Respiratory disorders: Mosad MT5 is not recommended for use in patients with respiratory disorders (both hypoxemia and hypercapnia). Appropriate tests should be performed to rule out respiratory distress syndrome before initiating therapy with this drug. Monitoring of heart functions is also important for heart patients who are about to take this medicine. Especially diseases such as heart failure, ventricular arrhythmias (including torsades de pointes), conduction defects, myocardial ischemia, electrolyte disturbances, hypokalemia.
2.5. Drug and food interactions
Alcohol should not be consumed during treatment with this medicine due to an increased risk of serious side effects such as nausea, headache, liver dysfunction, jaundice, fatigue,...The drugs can cause serious side effects. Interactions with Mosad MT5 include: Erythromycin. Haloperidol. Ketoconazole. Quinine. Amiodarone. Terfenadine. Sotalol. Anticholinergics: Because of their gastric motility effect, by activating Cholinergic nerves, anticholinergic drugs reduce the effectiveness of the drug. Foods that may interact with Mosad MT5: Grapefruit or grapefruit juice should not be consumed during treatment with Mosad MT5 due to an increased risk of serious side effects such as irregular heartbeat, restlessness, fatigue. fatigue, headache, nausea,...
2.6. Overdose when using Mosad MT5
Symptoms: Vomiting, abdominal pain, frequent urination. Treatment: Give activated charcoal or gastric lavage, closely monitor if symptoms do not improve, take the patient to a medical facility for intervention.3. How to use Mosad MT5
Tablets should be taken with cooled boiled water, without chewing or crushing them. Can be taken before or after meals. For adults, the usual daily dose is 15 mg of mosapride citrate anhydrous, divided into 3 doses before or after meals. Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
