Note when using antacid drugs, gastric juice

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The phenomenon of stomach has a lot of gastric acid can cause pain or ulceration of the digestive system. Therefore, antacids will neutralize the acid in the gastric juice, facilitating the regeneration of the gastric mucosa, helping to reduce pain and discomfort in digestive disorders.

1. What are gastric antacids?

Gastric antacids are a group of drugs that help neutralize the acid secreted in the digestive juices of the stomach used for conditions such as peptic ulcers, gastroesophageal reflux disease (GERD) and many forms of gastritis. . Antacids also act as buffers for stomach acid by increasing the pH to reduce stomach acidity. Some typical stomach acid antacids include:
Proton pump inhibitors H2 blockers Antacids Prostaglandins

2. Note when taking antacids

2.1 Proton pump inhibitors These are drugs that can inhibit total acid secretion and have a prolonged duration of action by strongly inhibiting H+-K+-ATPase located at the apex of parietal cells, which play a secreting role in secretion. protons. Thanks to their rapid and effective clinical effects, proton pump inhibitors are the main components of H.pylori eradication regimens.
Typical proton pump inhibitors include esomeprazole, oral or intravenous lansoprazole. Long-term proton pump inhibitor therapy can produce high gastrin levels, leading to chromophore-like hyperplasia. However, there is no evidence of dysplasia or metabolic malignancy in patients treated with this drug. Some cases of drug use can reduce the absorption of vitamin B12 in patients
2.2 H2 blockers This is a group of competitive inhibitors with histamine at the H2 receptor, thereby blocking gastrin-stimulating acid secretion and reducing the corresponding amount of gastric juice. Since H2 blockers are well absorbed from the gastrointestinal tract, their effects are dose-proportional and range from 6-20 hours, so the dose is often reduced in elderly patients. Common H2 blockers include cimetidine, ranitidine, and famotidine. Cimetidine has antiandrogen effects, manifests reversible gynecomastia and less commonly erectile dysfunction with prolonged use. In addition, H2 blockers may cause undesirable effects such as: mental status changes, diarrhea, rash, fever, myalgia, thrombocytopenia, sinus bradycardia, and hypotension after by rapid intravenous injection.
2.3 Antacids This is a group of drugs that neutralize stomach acid and reduce the activity of pepsin, but the drug can interfere with the absorption of some other drugs such as tetracycline, digoxin, iron, ... Antacids help relieve symptoms and heal ulcers in the digestive tract. Currently, antacids have been superseded by acid-suppressing therapy in the treatment of peptic ulcers and are used only for short-term symptom relief.
Aluminum hydroxide is a relatively safe antacid and is used therapeutically, however, if long-term, depletion of phosphate may occur due to aluminum binding in the gastrointestinal tract. This risk is increased in alcoholics, malnourished or patients with kidney disease. Aluminum hydroxide can also cause constipation. Magnesium hydroxide is a more effective antacid than aluminum but can cause diarrhea.

2.4 Prostaglandins Prostaglandins inhibit acid secretion by reducing cyclic AMP formation induced by histamine stimulation of parietal cells, thereby enhancing mucosal defenses. These derivatives are mainly used to reduce the risk of mucosal damage caused by NSAIDs, eg Misoprotol. However, Misoprotol has undesirable effects such as abdominal pain and diarrhea, especially causing strong miscarriage, so it is completely contraindicated in women of childbearing age who are not using contraception.
According to evaluation, diseases of the gastrointestinal tract in general and diseases of the stomach in particular are increasingly common in modern life. Therefore, when there are signs of disease, the patient should go to the hospital for examination and have appropriate medication indications.
Department of Gastrointestinal Endoscopy is one of the key specialties at Vinmec International General Hospital. To avoid the risk and timely treatment of pathological problems in the digestive tract. Please make an appointment to be examined by qualified and experienced doctors.

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