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Mikalogis drug whose main ingredient is Amikacin sulfate is indicated in the treatment of bacterial infections and infections. However, in the process of using Mikalogis, there may be some side effects such as low frequency toxic reactions. Therefore, patients need to follow the doctor's instructions for treatment with Mikalogis.
1. Mechanism of action of the drug Mikalogis
Mikalogis medicine contains amikacin sulfate, which is a semi-synthetic antibiotic of the aminoglycoside family. The drug has a rapid bactericidal effect by binding to the 30S subunit of the bacterial ribosome, and Mikalogis also blocks the synthesis of bacterial proteins.
Mikalogis drug when entering the body will be absorbed in the middle and penetrate through the cell membrane, so the activity of the aminoglycoside component can be greatly reduced in an anaerobic environment. However, the compound has a post-antibiotic effect with bactericidal activity that persists after serum concentrations have been reduced to minimum inhibitory concentrations. This property of the drug may explain the effectiveness of the once-daily drug.
The antibacterial activity of Mikalogis is mainly against aerobic gram-negative bacilli. The drug is not active against anaerobic bacteria and has no effect in acidic environments or with low oxygen pressure. Mikalogis also has limited activity against gram-positive bacteria. However, the drug may act synergistically with nafcilin or icillin against staphylococcus aureus.
2. Indications and contraindications to the use of Mikalogis
Indications:
Mikalogis is used in the treatment of infections caused by susceptible gram-negative and gram-positive bacteria including Pseudomonas sp.
Mikalogis is also indicated in the treatment of respiratory tract infections, urinary tract infections, abdominal infections, and gynecological infections.
Mikalogis is also indicated in the treatment of blood infections, bone and joint infections and skin and structural infections of the skin.
Contraindications:
However, Mikalogis is contraindicated in cases of hypersensitivity to the ingredients of the drug.
3. Dosage and how to use Mikalogis
For adults and older children: the recommended dose of Mikalogis for each day is 15 mg/kg, divided into 2 equal doses to be injected 12 hours apart. The total daily dose of the drug Mikalogis should not exceed 1.5 g. For neonates and premature infants: The starting dose of Mikalogis is 10 mg/kg body weight. The next dose of Mikalogis is 15 mg/kg/day, divided into 2 equal doses to be administered 12 hours apart. Life-threatening or Pseudomonas infections: The recommended dose of Mikalogis is 500 mg every 8 hours, up to a maximum of 1.5 g/day, for a maximum of 10 days. Uncomplicated urinary tract infections: The recommended dose of Mikalogis is 7.5 mg/kg/day divided into 2 equal doses administered 12 hours apart (equivalent to 250 mg twice daily for adults). great). In case patients with kidney failure can damage the kidneys, whether using Mikalogis prescribed by a doctor, kidney function must be monitored during treatment and the dosage may be changed in response to the condition. patient. It should be noted: The above recommended therapeutic dose for Mikalogis is for reference only. Therefore, before using Mikalogis medicine, patients need to be prescribed by a doctor.
4. Unwanted side effects when using the drug Mikalogis
Mikalogis medicine may cause some unwanted side effects during treatment. However, with each case Mikalogis can occur in varying degrees from mild to severe.
Some common side effects caused by Mikalogis include: dizziness, headache, rash, fever... These side effects can occur at the beginning of treatment or after increasing the dose of Mikalogis drug. . Usually, side effects from Mikalogis can be transient or subside over time.
However, in some cases Mikalogis can cause serious unwanted side effects with rare reactions. These reactions may appear after just a few minutes of using Mikalogis or longer within a few days. When serious side effects appear, such as: low frequency toxic reactions, decreased renal and auditory function, anemia, leukopenia, thrombocytopenia, increased blood pressure, paresthesia, tremor, myasthenia , joint pain... the patient should stop using Mikalogis and should get medical help immediately.
5. Some notes when using Mikalogis
The drug cnMikalogis has a nephrotoxic effect with increased serum creatinine. Urine has red blood cells, white blood cells, and oliguria. Changes in renal function may be reversible upon discontinuation of Mikalogis. Mikalogis should be used with caution when co-administered with neuromuscular blocking agents, as there is an increased risk of neuromuscular blockade leading to respiratory paralysis. Mikalogis drug may interact with other drugs such as broad-spectrum penicillin, indomethacin... Above is important information about Mikalogis drug, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor. indicated for best results.
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