Uses of Midantin

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1. Mechanism of action of the drug Midantin

What is Midantin? Midantin contains two ingredients Amoxicillin trihydrate and Clavulanic acid. Amoxicillin belongs to a group of antibiotics with a fairly broad spectrum and is stable in acidic environments. In particular, this compound has the ability to fight gram-negative bacteria. Similar to other antibiotic compounds, Amoxicillin exerts bactericidal action by inhibiting the biosynthesis of bacterial cell wall mucopeptides. However, Amoxicillin is inactive against penicillinase-producing bacteria, especially methicillin-resistant staphylococci and strains of Pseudomonas. Clavulanic acid belongs to the group of antibiotics in combination with Amoxicillin with broad antibacterial spectrum. The mechanism of action of this acid is due to the fermentation of Streptomyces clavuligerus, which has a beta-lactam structure similar to that of penicillin. This compound has a strong inhibitory effect on plasmid-transmitted beta-lactamases that cause resistance to penicillins and cephalosporins. Clavulanic acid also works to prevent Amoxicillin from being destroyed by beta-lactamases, and at the same time expands the antibacterial spectrum of Amoxicillin effectively.
With the properties and mechanism of action of the two ingredients in the drug Midantin, it shows that the drug can kill bacteria against Pneumonococus, beta hemolytic streptococus, staphylococcus ...
Midantin has two types divided by content:
Midantin 250 with amoxicillin content in the form of amoxicillin trihydrate 250mg and Clavulanic acid 31.25mg. Midantin 875/125 with amoxicillin 875mg and Clavulanic acid 125mg.

2. Indications and contraindications for the use of Midantin

Midantin is indicated for use in the treatment of diseases:
Upper respiratory tract infections including diseases related to the ears, nose and throat such as tonsils, sinusitis, otitis media. Lower respiratory tract infections such as acute bronchitis and chronic bronchitis, lobar pneumonia, bronchopneumonia. Genitourinary tract infections such as cystitis, pyelonephritis, urethritis. Skin and soft tissue infections with signs of boils, abscesses, cellulitis, and wound infections. Osteoarthritis with symptoms such as osteomyelitis. Oral infections and alveolar abscess formation Other infections may include septic abortion or abortion, obstetric infections, and intra-abdominal infections. However, Midantin is contraindicated for use in some cases:
People who are allergic to beta-lactam drugs such as penicillin and Cephalosporin. When using Midantin, there is a possibility of cross-allergy with beta-lactam antibiotics such as cephalosporins. Subjects with a history of jaundice, liver dysfunction caused by using drugs containing Amoxicillin and Clavulanate compounds or Penicillins. In addition, Clavulanic acid may increase the risk of intrahepatic cholestasis.

3. Dosage and how to use Midantin

Midantin is used to treat both adults and children.
For adults and children weighing over 40kg:
With normal kidney function, use Midantin at a dose of 80mg/kg body weight/day and 3 times. The total daily dose should not exceed 3 grams. Renal failure: If the patient's creatinine clearance is greater than 30ml/min, then use Midantin without dosage adjustment. The patient's creatinine clearance is from 10 to 30ml/min. The dose of Midantin should not exceed 15mg. /kg body weight/one dose and twice a day. Patients with creatinine clearance less than 10ml/min should not use Midantin more than 15mg/kg body weight in a day and after hemodialysis. For children weighing less than 40kg: Doctors prescribe Midantin at a dose of 20 to 40 mg/kg body weight/day and divided into 3 oral doses per day. Dosage and frequency of use of Midantin may depend on the severity of the infection.
Note: The above recommended therapeutic dose for Midantin is for reference only. Therefore, before using Midantin, patients need to be prescribed by a doctor.
If the patient has missed a dose of Midantin, the missed dose can be used as soon as he remembers. However, if the interval between the missed dose of Midantin and the next dose is close, the patient can skip the missed dose and take the next dose. Patients should also note that it is not recommended to use a double dose of Midantin, because it can cause drug overdose and unwanted side effects affecting current health.
In case the patient accidentally takes an overdose of Midantin than prescribed and shows some signs of unwanted side effects, it is necessary to take the patient to the nearest medical facility to receive emergency treatment. timely medical support, helping patients overcome dangerous situations.

4. Unwanted side effects and some notes when using the drug

4.1. Side effects Using Midantin can experience some unwanted side effects during treatment. These side effects can, on a case-by-case basis, be a common side effect or a rare side effect.
Common side effects of Midantin usually include symptoms such as diarrhea, rash, itching. Few or rare side effects of Midantin include eosinophilia, nausea and vomiting, hepatitis, cholestatic jaundice, and increased transaminases. The condition may become more severe and last several months with itching, erythema, or rash. A few rare side effects may be anaphylactic reactions. 4.2. Some Interactions of Midantin Drugs Midantin used with probenecid compounds may reduce the renal tubular secretion of Amoxicillin. At the same time, Clavulanic acid may increase the concentration of Amoxicillin in the blood. Therefore, the simultaneous use of these two drugs is not recommended. When Midantin is used concurrently with anticoagulants, two compounds of Midantin may prolong abnormal prothrombin time. Therefore, it is necessary to adjust the dose of oral anticoagulants accordingly. Concomitant use of Midantin with Allopurinol can significantly increase the incidence of rash in patients. Concomitant use of oral contraceptives and Midantin may cause a condition where the two compounds of Midantin affect the intestinal microflora. This results in decreased estrogen reabsorption and decreased effectiveness of oral contraceptives when used with Midantin. Midantin may form a false-positive reaction when a urine glucose test is performed.

5. Be careful when using Midantin

For pregnant women: There are currently not enough studies on the effects of Midantin in this situation. However, when using Midantin, patients should consult their doctor and weigh the possible benefits and risks. For women who are breastfeeding, the Amoxicillin compound in Midantin is excreted in breast milk. Therefore, it is very prudent to use Midantin for this subject. For elderly people when using Midantin, it is necessary to monitor kidney function. For people with liver failure when using Midantin, it is necessary to determine the appropriate dose and monitor liver function regularly.

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