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Midantin 250/62,5 belongs to the group of antiparasitic, anti-infective, antiviral and fungal drugs, used to treat respiratory, urinary, skin and soft tissue infections. Below is detailed information about what Midantin 250 is and what to note when using it.
1. What is Midantin 250?
Midantin 250 is prepared as a powder for oral suspension, with the main ingredients being Amoxicillin (as Amoxicillin trihydrate) 500mg and Clavulanic Acid (as Potassium clavulanate: microcrystalline cellulose, ratio 1:1) 62, 5mg with other excipients just enough for 1 tablet.
Amoxicillin is a semi-synthetic beta-lactam antibiotic with a broad spectrum of activity against many Gram-positive and Gram-negative bacteria by inhibiting bacterial cell wall synthesis. However, Amoxicillin is very easily degraded by beta-lactamase enzymes by hydrolyzing the lactam ring, so the drug has no effect on bacteria that produce this enzyme.
Clavulanic acid prevents Amoxicillin from being destroyed by beta-lactamases, and at the same time extends the antibacterial spectrum of Amoxicillin to many beta-lactamase-producing bacteria resistant to Amoxicillin when used alone without changing the mechanism of action of Amoxicillin.
Antibacterial spectrum of the drug:
Gram-positive bacteria: Aerobic type: Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus viridans, Streptococcus pyogenes, Staphylococcus aureus, Corynebacterium, Bacillus anthracis, Listeria monocytogenes. Anaerobic species: Clostridium species, Peptostreptococcus, Peptococcus species. Gram-negative bacteria: Aerobic type: Escherichia coli, Haemophilus influenza, proteus vulgaris, species Klebsiella, Shigella, Salmonella, Bordetella, Neisseria meningitidis, Neisseria gonorrhoeae, Vibrio cholerae, Pasteurella multocida. Anaerobic type: Bacteroides including B. Fragilis.
2. Uses of Midantin 250/62.5
Midantin 250/62.5 is used in the following cases:
Upper respiratory tract infections such as tonsillitis, sinusitis, otitis media have been treated with common antibiotics but have not been effective. Lower respiratory tract infections: Acute/chronic bronchitis, pneumonia caused by strains of H. influenzae, Branhamella catarrhalis secreting beta-lactamase. Genitourinary tract infections such as pyelonephritis, cystitis, urethritis, genital infections in women. Skin and soft tissue infections: Boils, abscesses, cellulitis, wound infections. Osteoarthritis: Osteomyelitis. Dental infections: Alveolar abscess Do not use Midantin when there is a history of allergy to beta-lactam antibiotics (Penicillin, Cephalosporin).
3. Dosage and how to use Midantin 250/62.5
Dosage depends on each subject:
The dose of the drug is calculated according to the dose of Amoxicillin in the compound. Adults: Take 250 - 500mg/time, every 8 hours/time; Children weighing over 40kg: Take according to the adult dose; Children weighing less than 40kg: The usual dose is 20mg/kg/day, divided into several divided doses every 8 hours. Treatment of sinusitis, otitis media, lower respiratory tract infections and severe infections, using a dose of 40mg/kg/day in divided doses every 8 hours for a course of 5 days. For patients with renal failure, it is necessary to adjust the dose and/or frequency of administration according to the renal creatinine clearance: Creatinine clearance >30ml/min: no dose adjustment is required. Creatinine clearance 15-30 ml/min: usual dose 12-18 hours apart. Creatinine clearance from 5-15 ml/min: usual dose 20-36 hours apart. Creatinine clearance <5 ml/min: usual dose every 48 hours. How to use:
Take the drug at the beginning of a meal to ensure tolerance in the gastrointestinal tract. The course of treatment should not exceed 14 days.
4. Side effects of Midantin 250/62.5
When using Midantin 250/62.5, patients may experience some unwanted effects as follows:
Digestive disorders: Stomach pain, diarrhea, nausea, vomiting, pseudomembranous colitis; Headache, fatigue; Rash, pruritus, urticaria, Stevens-Johnson syndrome; Liver damage: Hepatitis, cholestatic jaundice, elevated liver enzymes, which can be severe and persist for several months; Candida vaginitis; Elevated eosinophils. When using Midantin 250/62.5, if the patient experiences any side effects, stop taking the drug and contact the treating doctor or immediately go to a medical facility for timely treatment.
5. Interaction with Midantin 250/62.5
When using concomitantly Midantin 250/62.5 may interact with some of the following drugs:
Concomitant use with anticoagulants may prolong abnormal Prothrombin time, increase the risk of bleeding, because Therefore, the dose of anticoagulants should be adjusted as necessary. Concomitant use with Allopurino l may increase the likelihood of rash in patients. The drug can affect the intestinal microflora, leading to decreased reabsorption of the hormone estrogen, reducing the effectiveness of oral contraceptives containing a combination of estrogen and progesterone. Amoxicillin may cause a false-positive reaction in the urine glucose test. Concomitant use with Probenecid may reduce the renal tubular excretion of Amoxicillin, thereby increasing the concentration of Amoxicillin in the blood. Nifedipine may increase the absorption of Amoxicillin. Amoxicillin may reduce the excretion of methotrexate when used in combination, increasing the toxicity on the gastrointestinal tract and hematopoietic system of the drug.
6. Notes and cautions when using Midantin 250/62.5
When using Midantin 250/62.5, caution should be exercised in the following cases:
Be cautious with people with a history of impaired liver and kidney function, cholestatic jaundice. Although cholestatic jaundice symptoms rarely occur after taking the drug, they can be severe. However, these symptoms are usually reversible after 6 weeks of stopping treatment. Serious hypersensitivity reactions may occur in individuals with a history of allergy to penicillins, cephalosporins or other allergens. Before initiating treatment with Amoxicillin, a thorough history of allergy to these substances should be obtained. Prolonged use of the drug can cause drug resistance. The bladder catheter should be checked regularly to avoid clogging precipitates in the presence of high concentrations in urine at room temperature. Use with caution in pregnant and lactating women. Use only when absolutely necessary and under the direction of a physician. The drug does not affect the ability to drive and use machines. The article has provided information about what Midantin 250/62.5 is, dosage and notes when using. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Midantin 250/62.5 exactly as directed by your doctor.
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