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Mibevir 400mg has the main ingredient is the antiviral active ingredient Acyclovir. This product is mainly indicated for the treatment and prevention of Herpes Simplex infections. So what does Mibevir 400mg do?
1. What is Mibevir 400mg?
Mibevir 400mg contains active ingredient Acyclovir 400mg, in addition, Mibevir product also has 200mg strength.
Besides Acyclovir, the drug composition Mibevir 400mg also includes some excipients such as Avicel, Sodium glycolate starch, PVP K30, Magnesium stearate and Aerosil.
2. What is the effect of Mibevir 400mg?
The active ingredient Acyclovir in Mibevir 400mg is a nucleoside analogue with selective activity on cells exposed to Herpes virus. Acyclovir needs to undergo phosphorylation to convert to the active form, acyclovir triphosphate. It is this metabolite that inhibits DNA biosynthesis and viral replication in exposed cells without affecting the metabolism of normal cells.The effect of Mibeviru 400mg is strongest against Herpes Simplex virus type 1 (HSV-1), less effective against Herpes simplex virus type 2 (HSV-2) as well as
Varicella zoster virus (VZV) and weakest effect. for cytomegalovirus. During treatment with Mibeviru 400mg, some resistant strains of virus appeared and a latent amount of Herpes simplex virus in the lymph nodes was not destroyed. The active ingredient Acyclovir in Mibeviru 400mg is highly effective in treating severe encephalitis caused by HSV-1 virus, helping to reduce the mortality rate from 70% to 20%. At the same time, in cured patients, fewer serious complications were recorded. A milder form of meningitis caused by the HSV-2 strain can also be effectively treated with Mibevir 400mg.
Oral bioavailability of Mibevir 400mg is only about 20% (15-30%) and food does not affect the absorption of Acyclovir.
3. Indications and contraindications of Mibevir 400mg
Mibevir 400mg is indicated in the following cases:
Initial treatment and prevention of reinfection for Herpes simplex type 1 and type 2 in the skin and mucous membranes; Treatment of encephalitis caused by Herpes simplex; Treatment of acute Herpes zoster (shingles) infection, Shingles and Herpes Zoster pneumonia in adults; Initiation and prevention of recurrent genital herpes infections; Mibevir 400mg is also used in the treatment of hemorrhagic varicella, chickenpox in immunocompromised patients or in neonates. Mibevir 400mg drug is contraindicated for use in people with a history or a history of allergy to Acyclovir or any of the excipients in the drug.
4. Dosage and how to use Mibevir 400mg
Treatment with Mibevir 400mg should be initiated as soon as possible when the patient first develops signs and symptoms of the disease.
Mibeviru 400mg dose for treatment of Herpes simplex infections:
Adults: Mibeviru 200mg x 6 times/day (immunocompromised patients can take double dose of Mibeviru 400mg), orally every 4 hours for time 5-10 days; Children under 2 years of age: The recommended dose is 1⁄2 of the adult dose; Children over 2 years: The dose of Acyclovir is similar to that of adults. Mibevir 400mg dose to prevent recurrence of Herpes simplex in immunocompromised patients, organ transplant recipients receiving immunosuppressive drugs, patients with HIV infection or cancer chemotherapy:
Adults: 200-400mg x 4 times/day; Children under 2 years: 1⁄2 doses in adults; Children over 2 years old: The dose of Mibevir 400mg is equivalent to that of an adult. Dosage of Mibeviru 400mg in the treatment of chickenpox and shingles:
Adults: 800mg (2 Mibeviru 400mg tablets) x 6 times/day for 7 days; Children with varicella: The recommended dose of Acyclovir is 20mg/kg body weight (maximum 2 Mibevir 400mg) x 4 times/day for 5 days or: Children under 2 years old can take Mibevir 200mg x 4 times/day ; Children 2-5 years old dose Mibeviru 400mg x 4 times/day; Children over 6 years old: 2 tablets of Mibevir 400mg x 4 times/day. Dosage of Mibeviru 400mg in patients with renal failure infected with HSV or Varicella zoster is similar to normal people but the following issues should be noted:
Creatinine clearance 10-25ml/min: Take Mibeviru 400mg every 8 hours; Creatinine clearance less than 10 ml/min: Mibeviru 400mg every 12 hours.
5. Some cautions when taking Mibevir 400mg
As mentioned above, Mibevir 400mg should be used with caution in patients with renal impairment, requiring the physician to adjust the dose and administration according to the plasma creatinine clearance.
Pregnant patients should only use Mibevir 400mg (or other Acyclovir-containing preparations) when the benefits outweigh the possible risks to the fetus; Acyclovir is excreted in human milk, therefore caution should be exercised when Mibevir 400mg is administered to a nursing patient. The effect of Mibevir 400mg on the ability to drive and use machines has not been studied. Therefore, caution should be exercised in this case. Overdose of Mibevir 400mg and treatment:
Manifestation of Acyclovir overdose is the appearance of drug precipitation in the renal tubules when the concentration here exceeds the solubility of 2.5mg/ml of the drug or poisoning occurs in the patient. have high serum creatinine, kidney failure, arousal, restlessness, muscle tremors, convulsions, palpitations, increased blood pressure or difficulty urinating; Treatment of Acyclovir overdose: Continuous hemodialysis until renal function is restored, at the same time, it is necessary to stop using Mibevir 400mg and pay attention to the patient's water and electrolyte balance.
6. Undesirable effects of Mibevir 400mg
Cases of short-term treatment with Mibevir 400mg may experience side effects of nausea, vomiting. In addition, patients taking long-term (over 1 year) Mibevir 400mg may have abdominal pain, diarrhea, skin rash, headache (accounting for less than 5% of patients).
7. Drug interactions of Mibevir 400mg
Patients taking Mibeviru 400mg and Zidovudine concurrently may develop lethargy or lethargy. Probenecid reduces the clearance of the drug Mibevir 400mg. Amphotericin and Ketoconazole increase the antiviral potency of Mibevir 400mg.
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