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Metrima is an antifungal drug, used in the treatment of vaginal infections caused by pathogens sensitive to Clotrimazol such as vaginitis caused by fungi or Trichomonas, superinfection caused by bacteria sensitive to Clotrimazol.
1. What is Metrima 500mg?
Metrima 500mg drug has the main active ingredient is Clotrimazol, is made in the form of long vaginal tablets with a content of 500mg. In clinical practice, Clotrimazol 500mg can be combined with Metronidazol 100mg to form Metrima M vaginal tablets.
Clotrimazol is a synthetic broad-spectrum Imidazol antifungal drug. The mechanism of action of Clotrimazol is to bind to phospholipids on fungal cell membranes, leading to changes in membrane permeability and loss of essential intracellular substances leading to fungal cell destruction. Accordingly, Clotrimazol is effective against most pathogenic fungi. Local treatment of vaginitis caused by bacteria sensitive to Clotrimazol, usually Candida or Trichomonas.
Vaginal insertion of Clotrimazol 14C 100mg tablets results in peak serum concentrations of only about 0.03mcg Clotrimazol/ml after 1-2 days.
2. Uses of Metrima 500mg
2.1.Indications Metrima 500mg is indicated for the treatment of vaginal infections caused by pathogens sensitive to Clotrimazol:
Vaginitis caused by fungi (usually Candida) or Trichomonas. Vaginitis is caused by bacteria sensitive to Clotrimazol. 2.2. Contraindications Metrima 500ng is contraindicated in patients who are allergic or sensitive to any of the ingredients, and are hypersensitive to Imidazoles and other vaginal antifungal products.
3. How to use Metrima 500mg vaginal suppositories
Recommended dose: single dose x 1 time. Place one 500mg Metrima tablet deep into the vagina at night before going to bed. Wash your hands and intimate area thoroughly before inserting Metrima into the vagina.
In case the dose needs to be increased, a doctor's prescription must be obtained before use. If the symptoms of vaginitis such as discharge, vaginal itching do not completely subside within the following three days, consult your doctor to consider whether further treatment is necessary.
Currently, there is no reported risk of Metrima 500mg toxicity after a single vaginal administration. In the event of accidental ingestion of Metrima, conventional measures such as gastric lavage should only be taken if clinical symptoms of overdose become apparent (such as dizziness, nausea or vomiting).
4. Some notes when using Metrima 500mg . gynecological tablets
Do not use vaginal tablets during menstruation. If the patient experiences irritation in the area of application (swelling, redness, itching, appearance of blisters or burns) or signs of hypersensitivity, discontinue use and notify the physician immediately. appropriate handling. Avoid sources of infection or reinfection. Metrima does not affect the ability to drive or use machines. Pregnancy: There are currently no adequate data in pregnant women during the first trimester. Use Metrima in pregnant women in the first 3 months of pregnancy when prescribed by a doctor. Lactation: It is not known whether the drug is excreted in human milk. Use caution when using Metrima in this population.
5. Undesirable effects when using Metrima 500mg
Some possible side effects when using Metrima 500mg gynecological suppositories may be local reactions (>1%): burning, irritation, allergic contact dermatitis or burning pain at the injection site. .
When these symptoms do not improve or get worse, stop using the drug and immediately go to a medical facility for timely treatment.
6. Drug interactions
There have been no reports of synergistic or antagonistic effects between Clotrimazol and Amphotericin B, Nystatin or Flucytosin with Candida albicans species. Tacrolimus: Serum concentrations of liver transplant recipients are increased when co-administered with Clotrimazol. Therefore, the dose of Tacromilus should be reduced according to the need. Metrima is a vaginal tablet with the active ingredient Clotrimazol. The drug is indicated mainly in cases of vaginitis caused by fungi (usually Candida) or Trichomonas. Metrima is recommended as a single dose, vaginally in the evening before bedtime. Before using Metrima, you should go to a medical facility to be examined and accurately diagnosed the cause of the disease.
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