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Methylboston 16 is an anti-inflammatory drug, a corticosteroid in nature, used to treat pathologies such as adrenal insufficiency, rheumatoid arthritis, systemic diseases,... However, here it is. is a drug that should be prescribed exactly as indicated, in the right dose, should not be used indiscriminately without the examination of a doctor / medical professional.
1. What is Methylboston 16?
What is Methylboston? Methylboston 16 is a drug whose main ingredient is Methylprednisolone. The drug is manufactured by Boston Pharmaceutical Joint Stock Company Vietnam, has the effect of treating primary and secondary adrenal insufficiency; Rheumatoid arthritis , chronic arthritis in children, ankylosing spondylitis; Systemic lupus erythematosus; Pemphigus common; Allergic diseases; Uveitis; Acute lymphocytic leukemia...
Methylboston 16 mg is prepared in the form of tablets, packed in a box of 3 blisters, 10 tablets each.
2. Uses of the drug Methylboston 16
Methylboston 16 is used to treat the following pathologies:
Methylboston 16 (Methylprednisolone acetate) has the general properties of the glucocorticoid prednisolone, which has a long-acting effect due to its low solubility and difficult metabolism. Methylboston 16 has the active ingredient Methylprednisolone acetate which is hydrolyzed to the active form by serum cholinesterase enzymes. Drugs with a prolonged duration of anti-inflammatory activity of glucocorticoids are similar to the duration of decreased activity of the hypothalamic-pituitary-adrenal (HPA) axis. The half-life is dose dependent and can range from 4 to 8 days. The peak time of the drug is from 4 to 8 hours. Drugs metabolized by the liver are qualitatively similar to cortisol. The drug is eliminated mainly in the urine as glucuronides, sulfates and unconjugated compounds. Methylboston 16 contains glucocorticoids that penetrate cell membranes and bind to specific plasma cell receptors, which enter the cell nucleus and bind to chromosomal DNA. Thereafter, stimulation of messenger RNA transport and protein synthesis by various enzymes is considered to be mainly responsible for many properties after systemic administration. This not only has an important effect on the body's inflammatory and immune processes, but also affects carbohydrate, protein and fat metabolism. At the same time, these substances also affect the cardiovascular system, skeletal muscle and central nervous system. Methylboston drugs act on the inflammatory and immune processes, which will reduce the number of immune active cells near the site of inflammation, reduce capillary dilation, inhibit phagocytosis, reduce prostaglandin production. Drugs acting on carbohydrate and protein metabolism: Glucocorticoids have a catabolic effect on proteins. Amino acids are released, which are then converted to glucose and glycogen stored in the liver through gluconeogenesis. Decreased glucose absorption in peripheral tissues can lead to hyperglycemia and hyperglycemia, especially in patients with diabetes. In addition, the drug also has a fat-metabolizing effect, because glucocorticoids have lipolytic properties. This property affects mainly the limbs. The drug has a fat-forming effect, which is evident in the chest, neck and head.
3. Indications of the drug Methylboston
It should be noted that treatment with Methylboston 16 (Glucocorticoids) should only be considered as symptomatic treatment, except in the case of hormonal disorders where these drugs are used as an alternative.
Methylboston 16 is indicated in the following cases:
Endocrine disorders: Primary and secondary adrenal insufficiency, congenital adrenal hyperplasia. Joint diseases: Rheumatoid arthritis, chronic arthritis in children, ankylosing spondylitis. Systemic diseases: Systemic lupus erythematosus, systemic dermatomyositis (polymyositis), rheumatic heart disease, giant cell arteritis, polymyalgia rheumatica. Skin diseases: Pemphigus common. Allergic pathology: Severe allergic rhinitis, hypersensitivity allergic reactions to drugs, serum sickness, allergic contact dermatitis, bronchial asthma. Eye diseases: Anterior uveitis (iritis, iridocyclitis), posterior uveitis, optic neuritis. Respiratory system diseases: aspiration pneumonia. Blood diseases: Idiopathic thrombocytopenic purpura, hemolytic anemia (autoimmune pathology). Oncological pathology: Acute lymphocytic leukemia, malignant lymphoma. Diseases of the digestive system: Ulcerative colitis, Crohn's disease. Tuberculous meningitis, organ transplantation.
4. Dosage of Methylboston 16
Methylboston 16 is used with a starting dose of 4-48mg / day, patients should maintain and adjust the dose until there is an appropriate response. If treatment is prolonged, the lowest effective dose should be used by gradually reducing the dose until signs or symptoms improve. The drug should not be stopped abruptly during long-term use of high doses, but should be reduced gradually.
The doctor will prescribe the lowest dose to have the right effect for the disease. You should take the pill at 8 a.m. daily and take the tablet whole with plenty of water, without chewing.
Specific cases will have different dosage:
Sarcoid disease: dose 0.8mg/kg/day. Maintenance dose: 8mg/day. Exacerbation of multiple sclerosis: The first week's dose is 160mg, then the dose is reduced to 64mg per day for 1 month. Severe rheumatoid arthritis: 16mg/day. Systemic myositis: 48 mg/day. Systemic lupus erythematosus: 16-100 mg/day Acute rheumatic fever: 48 mg/day until ERS normalize for 1 week. Allergic diseases: 16-40 mg/day. Asthma: 64 mg/day or up to 100 mg/dose every other day. Eye disease: 16-40 mg/day. Blood and white blood cell disease: 16-100 mg/day. Malignant lymphoma: 16-100 mg/day. Ulcerative colitis: 16-60 mg/day. Polymyalgia rheumatica: 64 mg/day Pemphigus: 80-360 mg/day. It should be noted: The above dosage is for reference only, users need to strictly follow the instructions of the doctor to achieve the best effect.
5. Contraindications to using Methylboston 16
Do not use Methylboston 16 in the following cases:
People with hypersensitivity to drug components: Methylprednisolone. The patient is receiving a live attenuated vaccine. Severe infections except septic shock and tuberculous meningitis. In case of skin lesions caused by viruses, fungi or tuberculosis.
6. Interactions of Methylboston 16
The drug should not be used concurrently with cyclosporin, phenobarbital, phenytoin, rifampin and hypokalemic diuretics, because it may reduce the effect of Methylboston and may not control the side effects of the drug. Methylboston 16 (Methylprednisolone) can cause hyperglycemia, so higher insulin doses are needed in diabetics.
7. Side effects of Methylboston 16
When taking the drug in high doses and for a long time, there may be side effects:
Insomnia, irritability Increased appetite but difficulty in digestion. Eyebrows, eyelashes, mustache, pubic hair grow. Metabolic disorders: diabetes. Eye diseases: cataracts, glaucoma. Swollen face, heavy limbs. Hypertension. Osteoporosis, broken bones. Caviar, skin hyperpigmentation. Cushing's syndrome. Adrenal insufficiency. Reduced potassium, water retention. Stomach ulcers. Amenorrhea. In addition, there are many other symptoms that are not listed above, if you experience any unpleasant symptoms while taking this medicine, please immediately notify your doctor / pharmacist for advice.
8. Be careful when using Methylboston 16
In the course of taking Methylboston 16, care should be taken in the following cases:
Do not stop the drug suddenly after a long time of treatment or when there is stress because it will easily lead to acute adrenal insufficiency. Caution should be exercised in patients with osteoporosis, new vascular connections, mental disorders, peptic ulcers, diabetes, hypertension, heart failure, and growing children because of the long-term use of the drug, the dose high will increase unwanted side effects. With caution in the elderly, it should be used at the lowest dose and for the shortest possible time for the drug to be effective for the treatment disease. Use caution when using for drivers or machine operators, pregnant and lactating women, because the drug causes dizziness and central nervous system disorders, so it should be used with caution in this subject. Above is the detailed information about the drug Methylboston 16, in the process of taking the drug, if you have any questions or problems, please contact your doctor for advice.
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