Uses of Merislon

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1. What is Merislon?

Merislon medicine contains the active ingredient Betahistine mesilate - a substance similar to histamine, which is found naturally in the human body.
Merislon has a direct stimulating effect on the H1 receptors located on the blood vessels in the inner ear. It acts on the anterior capillary sphincter in the blood vessels of the inner ear. Thus reducing the pressure in the endolymph space.
In addition, Merislon has a strong antagonistic effect at H3 receptors and increases the level of neurotransmitters released from nerve endings. An increase in the amount of histamine released from histaminergic nerve terminals stimulates H1 receptors, increasing the direct active effect of Merislon on H1 receptors. Therefore, Merislon is a potent vasodilator in the inner ear and is used in the treatment of vertigo.
Thanks to the combination of the above effects, Merislon is indicated for the treatment of Ménière's syndrome. This syndrome is characterized by the following signs: dizziness, tinnitus, nausea, headache, hearing loss. The effectiveness of Merislon may be due to its ability to regulate circulation in the inner ear or to a direct effect on the neurons of the vestibular nucleus.
Merislon medicine is made in the form of tablets with a strength of 6mg or 12mg.

2. Uses of Merislon

Merislon is indicated for the treatment of symptoms associated with Ménière's syndrome such as hearing loss, tinnitus, dizziness, nausea.

3. Usage- Dosage of the drug Merislon

3.1. How to use Patients need to drink Merislon tablets whole with a glass of water, absolutely do not chew, crush or break the tablet. Merislon should be taken with meals, as it causes mild stomach related problems. 3.2. Dosage Dosage depends on the medical condition, the doctor will prescribe the appropriate dose for each patient. The use of Merislon for treatment can be long-term and last several months.
In adults:
Initial oral treatment is 6 to 12 mg, three times daily, preferably with meals. Maintenance dose: 24-48mg per day. The daily dose should not exceed 48mg. Children and adolescents:
Merislon tablets are not recommended for use in children and adolescents under 18 years of age due to a lack of data on safety and efficacy. What to do if you miss a dose of Merislon?
Patients need to take the supplement as soon as they remember, if it is almost time for the next dose, skip the missed dose and take the next dose as directed. Do not double the dose of Merislon to make up for a missed dose. What to do in case of an overdose of Merislon?
There have been a few cases of overdose reported. Some patients have had mild to moderate symptoms with doses up to 640 mg (eg, nausea, somnolence, abdominal pain). Other symptoms of Merislon overdose are vomiting, indigestion, convulsions. More serious complications (such as pulmonary or cardiac complications) have been observed in cases of intentional overdose of Merislon, especially when combined with other drugs that also overdosed. There is no specific antidote. Gastric lavage and symptomatic treatment of overdose with Merislon are recommended within one hour of ingestion.

4. Contraindications to the drug Merislon

Merislon is contraindicated in the following cases:
Patients with hypersensitivity to Betahistine mesilate, or any excipients in the drug Merislon. Merislon is contraindicated in patients with phagocytosis. Since betahistine is a synthetic analogue of histamine, it can cause catecholamine release from tumors, leading to severe hypertension.

5. Merislon drug side effects

When using Merislon may cause the following undesirable effects:
Vomiting, nausea, severe abdominal pain, drowsiness. Rarely allergic reactions

6. Notes on the use of the drug Merislon

6.1. Pregnancy There are insufficient data on the use of Merislon in pregnant women. Animal studies, although insufficient, do not indicate direct or indirect harmful effects on reproductive toxicity with exposure to clinically relevant therapy. Potential hazards to humans are unknown. As a precaution, it is best to avoid using Merislon during pregnancy.
6.2. Lactation It is not known whether Merislon is excreted in human milk. But Merislon is excreted in rat milk. Postpartum effects seen in animal studies were limited to very high doses. Your doctor will weigh the benefits and risks of Merislon to prescribe treatment.
6.3. Driving and using machines In clinical studies, Merislon did not have a significant effect on the ability to drive and use machines.

7. Special notes before using the drug Merislon

Caution should be exercised when treating Merislon in patients with peptic ulcer disease or a history of peptic ulceration, as occasional dyspepsia may occur in patients receiving Merislon. Clinical intolerance to Merislon may occur in patients with bronchial asthma. Therefore, these patients should be carefully monitored during treatment with Merislon. Merislon should be treated with caution in patients with urticaria, rash or allergic rhinitis, because of the potential for aggravation of these symptoms. In patients with severe hypotension, Merislon should be used with caution. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take Merislon. Merislon drug contains the active ingredient Betahistine mesilate, used to treat Ménière's syndrome, symptoms include dizziness, tinnitus, hearing loss... To ensure effective use, users need to follow the directions exactly. by doctors and pharmacists.
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