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Sakardro 250 is a 1st generation Cephalosporin antibiotic with a moderate bactericidal spectrum. The drug is indicated for mild infections, patients rarely use antibiotics.
1. What are the uses of Sakardro 250?
Sakardro 250 medicine has the main ingredient Cefadroxil (as Cefadroxil monohydrate) 250mg. The dosage form is powder for oral suspension.
Cefadroxil is a first generation cephalosporin antibiotic. Cefadroxil is an antibiotic with a medium spectrum of activity, active against gram-positive bacteria such as staphylococcus, streptococcus, pneumococcus, except streptococcus resistant to Methicillin. This drug is also active against a small number of gram-negative bacteria such as E.coli, Klebsiella pneumoniae, Proteus mirabilis and Shigella. The mechanism of action of Cefadroxil as well as other Beta lactam drugs is to inhibit bacterial cell wall synthesis, the drug has a bactericidal effect by inhibiting the final stage of bacterial cell wall synthesis. bacteria, making the bacteria without a strong wall to protect will be destroyed.
2. Indications and contraindications of the drug Sakardro 250
Sakardro 250 is indicated for use in the following cases:
Urinary tract infections: Bacterial infections causing acute and chronic pyelonephritis, cystitis, urethritis. Respiratory tract and ear, nose and throat infections including: tonsillitis, rhinosinusitis, pharyngitis, bronchopneumonia and lobar pneumonia, acute and chronic bronchitis, pleurisy, laryngitis, otitis Between. Skin and soft tissue infections such as lymphadenitis, abscess, cellulitis or ulcer. Osteomyelitis, inflammatory arthritis. Contraindications:
Do not use Sakardro in patients with hypersensitivity to Cefadroxil or to Cephalosporin antibiotics or to any other excipients.
3. Dosage and how to use Sakardro 250
How to use:
Mix this powder with filtered or boiled water to cool, stir well and drink. The drug can be taken immediately with a meal or should be taken on an empty stomach to increase drug absorption. For patients with digestive disorders, the drug should be taken with food. Dosage:
For adults: Take 500-1000mg/time, take 1 to 2 times/day depending on the degree of infection. Children > 6 years: Take 500mg x 2 times/day. Children 1 - 6 years old: Take 250mg x 2 times/day. For neonates and premature babies: Treatment experience is limited. Dosage adjustment is required in the elderly and in patients with renal impairment.
Patients with renal impairment: Can be treated with an initial dose of 500 - 1000mg Cefadroxil, subsequent doses can be adjusted depending on the degree of renal impairment as follows:
Creatinine clearance 0 - 10ml/min: Dose maintenance is 500mg, taken every 36 hours. Creatinine clearance 10-25ml/min: The maintenance dose is 500mg, every 24 hours. Creatinine clearance 25 - 50ml/min: Maintenance dose is 500mg, every 12 hours. Hepatic impairment: no dose adjustment is required.
4. Sakardro 250 . side effects
When taking the drug you may encounter side effects such as:
Common: Digestive disorders such as nausea, vomiting, abdominal pain, diarrhea. Uncommon: Eosinophilia; maculopapular rash, exanthema, urticaria, pruritus; reversible increase in liver transaminases; testicular pain, vaginitis, candidiasis, genital itching. Rare: Anaphylactic reactions, serum sickness, fever; neutropenia, thrombocytopenia; hemolytic anemia, causing a positive Coombs test; pseudomembranous colitis; erythema multiforme, Stevens - Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), angioedema, common pemphigus; cholestatic jaundice , hepatitis ; nephrotoxicity with a temporary increase in blood urea and creatinine, reversible interstitial nephritis; convulsions (with high doses and impaired renal function), headache, agitation; athritis. Unspecified frequency: Chest pain, coughing up blood, nosebleeds; heart palpitations ; increased menstrual volume or vaginal bleeding; wheeze; Abnormal weight loss without applying weight loss measures. Inform your doctor about any unwanted effects you experience while using the drug. Some of the side effects are mild enough that Cetadroxil will go away with just stopping. In case of severe allergy or severe hypersensitivity reaction, supportive treatment should be instituted. Patients with mild pseudomembranous colitis usually only need to stop taking the drug; For moderate and severe cases, it is necessary to note the addition of fluids and electrolytes, the antibiotic Metronidazol.
5. Pay attention to precautions when using Sakardro 250
Antibiotics are used under a doctor's prescription and are only used for bacterial infections, not for viral infections. Use with caution in patients with a history of allergy to penicillin because cross-allergies have been observed; patients with renal failure; have asthma or severe allergies; patients with gastrointestinal diseases, especially colitis. Adhering to the correct dose and duration can help prevent re-infection and antibiotic resistance. Long-term use of Cefadroxil as well as other antibiotics may result in overgrowth of non-susceptible strains. Patients should be carefully monitored, if superinfection, the drug must be discontinued and appropriate treatment measures. Cefadroxil may be excreted in low concentrations in breast milk; however, caution should still be exercised when this drug is administered to a nursing woman, especially if the infant has diarrhea, thrush and rash. The level of safety for pregnant women is unknown, should only be used when absolutely necessary. Drug Interactions: Concomitant administration of Sakardro 250 with potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes may lead to increased serum potassium and in heart failure patients to increased creatinine. serous; Cholestyramine can bind to cetadroxil in the intestine, slowing the absorption of the drug; Concomitant use of Cefadroxil with Probenecid may reduce the excretion of Cetadroxil; Concomitant use of Cefadroxil with Furosemide and Aminoglycosides may cause synergistic increases in nephrotoxicity. Storage: Store Sakardro 250 in a tightly closed container, in a cool, dry place. Avoid direct light on the medicine. Check the expiration date before use and do not use if the medicine is past its expiration date or shows signs of deterioration. The basic information about Sakardro 250 in the above article is for reference only. Because this is a prescription drug, patients should not use it on their own, but need to contact a specialist directly to get an appropriate prescription to ensure safety for health.
