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Janumet 50 850 is manufactured by Pantheon Puerto Rico, Inc. - PUERTO RICO and registered by Merck Sharp & Dohme (Asia) Ltd. The drug belongs to the group of hormonal drugs. So what disease does Janumet 50 850 treat?
1. What is Janumet?
Janumet 50/850 is a drug containing the main ingredients including 2 active ingredients: Sitagliptin with a content of 50mg and Metformin hydrochloride with a content of 850mg with excipients just enough for 1 tablet, made in the form of film-coated tablets. Package in the form of a box of 4 blisters, 1 blister contains 7 tablets.
2. Uses of Janumet 50/850
2.1. The effect of the drug Janumet 50/850 Active ingredient Sitagliptin has a selective inhibitory effect on DPP-4, helping to reduce insulin levels and increase the response of insulin to Glucose.
Active ingredient Metformin hydrochloride is a biguanide antihyperglycemic drug. For people with moderate blood sugar levels, the drug has no effect on lowering blood sugar. The drug is only effective in lowering blood sugar in people with diabetes.
2.2. Indications of the drug Janumet 50/850 Janumet is indicated in the treatment of type 2 diabetes, in combination with drug therapy, with a reasonable diet and physical exercise in the following cases:
For patients who have followed a reasonable diet combined with exercise but cannot control blood sugar. When the patient has been treated with Metformin alone to reach the maximum tolerated dose or is using a combination of Sitagoliptin and Metformin in separate doses but has not controlled blood sugar, the use of Janumet is indicated. Janumet is indicated in 3-drug combination therapy with Sulfonylurea when the patient cannot control blood sugar with any 2 of the following 3 drugs: Sulfonylurea, Metformin, Sitagliptin. When the patient has not controlled blood sugar with any 2 of the following 3 drugs: PPARy agonist, Metformin, Sitagliptin, it is necessary to use Janumet in a 3-drug combination therapy with a PPARy agonist. Use of Janumet in combination therapy with insulin. 2.3. Contraindication to the drug Janumet 50/850 Contraindication to the use of Janumet in patients with:
Patients with hypersensitivity reactions to any component of the drug, including active ingredients and excipients in the drug Janumet . Patients with acute or chronic metabolic acidosis. Including diabetic ketoacidosis with or without coma. Chronic or acute conditions can deplete tissue oxygen such as: respiratory failure, heart failure, shock, myocardial infarction. Do not use on subjects with liver failure, alcoholism, acute alcohol poisoning, lactating women, kidney disease or kidney dysfunction, sepsis. When the patient has X-ray and intravenous radioactive iodinated contrast, the use of Janumet should be temporarily discontinued.
3. How to use and dose Janumet 50/850
3.1. How to use Patients should use Janumet 2 times a day with meals, including 1 time in the evening for the most effective blood sugar lowering effect. The dose should not be increased suddenly, as this may lead to undesirable effects (on the gastrointestinal tract of Metformin). The drug is prepared in the form of film-coated tablets that should be taken directly with filtered water. Accordingly, the patient must not break, chew, bite or crush the tablet. 3.2. Dosage Adjustment of the starting dose of the drug depends on the patient's condition. Patients may be dosed according to efficacy and tolerability. However, the maximum daily therapeutic dose of 100mg Sitagliptin and 2000mg Metformin should not be exceeded.
The recommended doses of Janumet are as follows:
50mg sitagliptin/500mg metformin hydrochloride 50mg sltagliptin/850mg metformin hydrochloride 50mg sltagliptin/1000mg metformin hydrochloride For specific and special cases, patients can refer to the leaflet. Instructions for use in each box of medicine and consult a doctor before treatment with Janumet, to avoid self-administration to appear unwanted effects.
4. Undesirable effects when using the drug Janumet
In the process of using Janumet, patients may experience some of the following side effects:
Common unwanted effects when using Janumet are: erythema, skin fungus, photosensitivity, eyebrows urticaria, decreased vitamin B12 levels, hypoglycemia, cough, vomiting, nausea, flatulence, dyspepsia, abdominal pain. Less common side effects include: pruritus, constipation, diarrhea, hemolytic anemia, myelosuppression, thrombocytopenia, blood dysplasia, agranulocytosis, lactic acidosis. Side effects of unknown frequency include: acute pancreatitis, hypersensitivity reactions, angioedema, urticaria, rash, capillary inflammation, arthralgia, back pain, extremity pain, myalgia. Acute renal failure. When experiencing any unwanted effects, the patient should stop using the drug and contact the doctor immediately for guidance on timely treatment.
5. Janumet drug interactions
Caution when using Janumet with cationic drugs excreted in the renal tubules.
In addition, during use, there may be competition or interaction between Janumet with food and other functional foods. Therefore, patients need to consult with their doctor about foods and supplements that should be avoided during treatment with Janumet.
6. Pay attention to the use of the drug Janumet
During the use of Janumet, patients should pay attention to the following:
For cases of lactic acidosis, hypoglycemia (fatigue, tremor, sweating, dizziness) need to be considered. Use caution when using Janumet. Watch out for vitamin B12 deficiency, as Janumet can reduce levels of this vitamin. Patients should not drink alcohol while taking the drug. Do not use the drug for children under 18 years old, pregnant and lactating women. Janumet 50/850 is a drug containing two active ingredients: Sitagliptin 50mg and Metformin hydrochloride 850mg. The drug is indicated for the treatment of type 2 diabetes. To ensure effective treatment, patients need to strictly follow the instructions of a doctor, professional pharmacist.
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