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Fargel 75 is an antiplatelet drug, used to prevent blood clots that cause cardiovascular disease and stroke in people with risk factors. So how does the drug work and what should be paid attention to when taking it?
1. What is Fargel 75?
Fargel 75 contains the main ingredient is Clopidogrel, which has the effect of preventing disorders caused by thromboembolism. The Clopidogrel component in Fargel 75 is a selective inhibitor of the adenosine diphosphate (ADP) precursor on the platelet receptor and thereby leads to ADP-mediated activation of the GPIIb/IIIa glycoprotein complex. Therefore, platelets cannot aggregate, preventing the formation of blood clots in the blood vessels.
Fargel 75 is rapidly absorbed orally when taken orally, unaffected by food. After entering the body, the drug is bound to plasma proteins from 94-98%. Fargel 75 is metabolised in the liver and excreted in feces and urine.
2. Indications of the drug Fargel 75
Fargel 75 is indicated for treatment in the following cases
Prophylaxis of primary thromboembolic disorders such as ischemic stroke, myocardial infarction, peripheral arterial disease. Prevention and control of secondary disorders in patients with atherosclerosis, recent stroke (less than 35 days) or recent myocardial infarction. In combination with aspirin for the treatment of acute coronary artery disease, unstable angina.
3. Contraindications of Fargel 75
Fargel 75 is not indicated for treatment in some of the following medical conditions
Allergy to the ingredient Clopidogrel or any other substance in the drug. Gastrointestinal ulcers cause bleeding. Intracranial hemorrhage. Severe liver failure
4. Interactions of Fargel 75 with other drugs
When aspirin and Fargel 75 are combined, a pharmacodynamic interaction may occur, leading to an increased risk of bleeding.
Concomitant use of Heparin and Fargel 75 also increases the risk of bleeding, especially gastrointestinal bleeding.
Anticoagulants such as Warfarin may cause an increase in disseminated bleeding when combined with Fargel 75.
Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) may cause potential bleeding in the gastrointestinal tract. Gastrointestinal symptoms should be monitored regularly while taking the drug.
Drugs metabolized in the liver by the Cytochrome P450 system may be reduced effectiveness because the component Clopidogrel in the drug inhibits the enzyme Cytochrome P450.
Fargel 75 will be reduced effect, increased elimination when used with some drugs Omeprazole, fluvoxamine, moclobemide, ciprofloxacin, cimetidine, carbamazepine, chloramphenicol.
5. Dosage and usage
How to use Fargel 75
Take orally. Drinking during or after meals.
Dosage of Fargel 75
History of atherosclerosis: take 1 tablet (75mg)/day. Prevention of thromboembolic disorders: take 1 tablet (75mg)/day. Acute coronary syndrome: At the beginning of an attack, a single dose of 300mg, then a maintenance dose of 75mg (1 tablet)/day. No dose adjustment is required in patients with renal impairment.
6. Side effects of the drug Fargel 75
Some unwanted effects may be encountered when taking Fargel 75
6.1 Common side effects Diarrhea, dyspepsia, epigastric pain, digestive disorders. Erythema, allergy, pruritus. 6.2 Uncommon side effects Anxiety, chest tightness. Epistaxis . 6.3 Rare side effects Gastrointestinal bleeding. Stomach ulcers. Agranulocytosis, decrease or loss of neutrophils. Thrombocytopenia, intracranial hemorrhage, orbital hemorrhage. Hemolytic anemia. Nephrotic syndrome. Taste disorder. Acute arthritis.
7. Notes when using Fargel 75
Patients with bleeding due to trauma, surgery or other conditions should be cautious and consider Fargel 75.
Patients preparing for surgery, must stop using Fargel 75 5 days before surgery. In patients with active ulcerative lesions, the use of drugs has the potential to increase the risk of bleeding.
Patients with impaired hepatic metabolism taking drugs with the potential for increased toxicity and side effects should carefully monitor liver function before and during treatment.
There are no specific studies on the effects of the drug on embryos and children. Therefore, the drug should only be used by pregnant and lactating women when absolutely necessary.
In summary, Fargel 75 is an antiplatelet drug that causes blood clots in the blood vessels. The drug has the effect of preventing and controlling some cardiovascular diseases caused by thrombosis. However, there is a risk of bleeding, especially in patients taking combination anticoagulants. Therefore, the use of the drug must be under the direction and strict supervision of the doctor.
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