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Medamben is a cephalosporin antibiotic commonly indicated in mild to moderate infections caused by susceptible organisms. So what is the mechanism of action and what should be noted when using the drug?
1. What is Medamben?
Medamben's main ingredient is Cefadroxil - a first-generation Cephalosporin antibiotic. Cefadroxil is used in mild to moderate infections, sensitive to gram-positive strains of bacteria such as staphylococcus, streptococcus, pneumococcus, and pneumococcus. cocci, ... and some strains of gram-negative bacteria such as Klebsiella pneumoniae, Proteus mirabilis, E.coli, Shigella,....
Like other Cephalosporin antibiotics Medamben acts through the mechanism of inhibition of synthesis bacterial cell wall, thereby killing bacteria, making them unable to multiply. Medamben is rapidly absorbed after oral administration, reaching peak plasma concentrations within a few hours, widely distributed in tissues and body fluids. Finally, the drug is eliminated in the urine as unchanged drug.
2. Indications of the drug Medamben
Medamben is indicated in the following pathological cases:
Urinary tract infections: urethritis, cystitis, pyelonephritis, gynecological infections,... Skin infections and soft tissue: Cellulitis, boils, erysipelas, lymphadenitis, ulcers caused by prolonged lying down,... Respiratory tract infections: Pharyngitis, tonsillitis, bronchitis, pneumonia, abscesses pneumonia, sinusitis, laryngitis, otitis media. Some other infectious diseases such as: septic arthritis, osteomyelitis,... In some cases, Medamben should not be used.
Allergic to Cefadroxil ingredients, cephalosporin antibiotics or any other ingredients of drugs. Infants and children under 1 year of age are not indicated for use of Medamben. Note when using Medamben
Patients with a history of allergy to penicillin antibiotics, peptic ulcer disease, colitis should be cautious when using the drug. Monitor renal function before and during administration of Medamben in patients with impaired renal function. Long-term use of Medamben may cause overgrowth of non-susceptible strains, causing superinfection, possibly fungal infections. The safety of the drug is not guaranteed for infants and children under 1 year of age. The drug crosses the placenta and breast milk, there are no studies to ensure the safety for the fetus and children. Therefore, pregnant and lactating women only use the drug when absolutely necessary.
3. Medamben drug interactions
Co-administration of Cholestyramine and Medamben reduces the absorption of the drug in the intestine. Probenecid may decrease the excretion of Medamben when taken together. Diuretics (Furosemid), aminoglycosides can synergistically act with Medamben to increase nephrotoxicity.
4. Dosage and usage
How to use
Medamben is in the form of hard capsules. Take the medicine during or after a meal. Avoid crushing or breaking the tablet. Dosage
Adults: Take 1-2 tablets (500mg)/time x 2 times/day. Children 1 - 6 years old: Take 1⁄2 tablets (250mg)/time x 2 times/day Children over 6 years old: Take 1 tablet (500mg)/time x 2 times daily. Patients with renal failure, elderly patients adjust the dose of Medamben according to the instructions of the doctor.
5. Side effects of the drug Medamben
Some unwanted effects may be encountered when taking Medamben
Common side effects
Nausea, vomiting, digestive disorders. Abdominal pain, diarrhea. Uncommon side effects
Eosinophilia. Urticaria, pruritus, maculopapular rash, exanthema. Reversible elevation of liver transaminases. Testicular pain, vaginitis, Candida infection. Rare side effects
Anaphylactic reactions, fever. Neutropenia, thrombocytopenia, hemolytic anemia, positive Coombs test. Pseudomembranous colitis. Stevens-Johnson syndrome. Common Pemphigus pathology, Lyell's syndrome, angioedema. Hepatitis, elevated liver enzymes (SGOT, SGPT), cholestatic jaundice. Reversible interstitial nephritis, increased urea, blood creatinine. Convulsions, headache, agitation (use high doses when renal function is impaired). Joint pain. In summary, Medamben is a broad-spectrum antibiotic, sensitive to many strains of Gram-negative and Gram-positive bacteria. Medicines must be prescribed by a doctor, avoiding abuse and misuse of drugs to cause some unwanted effects on the body.
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