This is an automatically translated article.
Erectile dysfunction is a sexual dysfunction in men that causes the penis to be unable to get an erection or not enough to perform sexual intercourse. This condition can be quickly improved by Loxmen, but this is a drug to be taken as prescribed by a doctor.
1. What is Loxmen?
What is Loxmen? Loxmen medicine has the main active ingredient is Sildenafil, manufactured by Daewoong Pharm Co., Ltd - Korea. Loxmen is prepared in the form of film-coated tablets, circulating on the market with 2 strengths, Loxmen 50mg and Loxmen 100mg.
The drug Loxmen works by affecting the erection process in men. An erection is a phenomenon in which the penis is filled with blood, this blood stasis occurs when the blood vessels leading to the penis lead to an increase in blood supply, while the blood vessels that carry blood out of the penis decrease blood flow. More blood coming in than going out causes an erection.
Under normal conditions, sexual arousal touches lead to the production and release of nitrogen oxides in the penis. Nitrogen oxide activates the enzyme guanylate cyclase, which produces GMPc responsible for causing an erection by affecting the amount of blood entering and leaving the penis. Sildenafil inhibits the enzyme phosphodiesterase-5 (PDE5), which is the enzyme that destroys GMPc, thus allowing GMPc to accumulate and persist longer. The longer GMPc persists, the longer the blood stasis in the penis lasts, helping to maintain an erection.
2. What are the uses of Loxmen?
Loxmen is used to treat erectile dysfunction, which is the inability to achieve or maintain an erection sufficient to satisfy sexual activity.Loxmen is only effective when taken at the time of accompanying sexual stimulation.
3. Dosage and how to use Loxmen
Loxmen is taken orally. In order for the drug Loxmen to work, it is necessary to have sexual stimulation after using the drug.
Loxmen is used for adults over 18 years old with the following dose of Loxmen: 50mg taken about 1 hour before sexual activity. Based on efficacy and tolerability with prolonged use, this dose can be increased to 100mg or vice versa can be reduced to 25mg depending on the specific case, however the maximum dose of Loxmen is 100mg. The frequency of taking Loxmen is 1 time per day. For the elderly: The first dose of Loxmen is 25mg, then based on efficacy and tolerability, the dose of Loxmen can be increased to 50mg or 100mg. For patients with mild to moderate renal impairment (creatinine clearance 30 - 80ml/min), use Loxmen as normal adults. For patients with severe renal impairment (with creatinine clearance <30ml/min), the first dose of Loxmen is 25mg. Then, depending on the effectiveness and tolerability, the dose can be adjusted up to 50mg and 100mg. Due to reduced clearance of active substance Sildenafil in patients with impaired liver function (eg: cirrhosis) is reduced. Therefore, the initial dose of Loxmen should be 25 mg. Finally, based on the efficacy of Loxmen and tolerability, the dose may be increased to 50 mg and 100 mg. Note, for all subjects using Loxmen: do not use more than 100mg / day and do not use more than 1 time in 24 hours.
4. Contraindications of the drug Loxmen
Loxmen is contraindicated in the following cases:
Do not use Loxmen for children and women; Contraindicated to use Loxmen for patients with a history of coronary artery disease, cerebrovascular disease; People who are allergic to any ingredient in Loxmen ; With regard to the specific effects of Loxmen through GMPc destruction, Sildenafil may lower blood pressure in patients receiving organic nitrate salts (regular or intermittent use). All are contraindications of Loxmen.
5. Drug interactions of the drug Loxmen
Sildenafil is metabolized mainly through cytochrome P450 3A4 and 2B9, so cytochrome inhibitors such as Cimetidine, Erythromycin, Ketoconazole, Itraconazole, Ritonavir... will reduce the elimination of active ingredient Sildenafil, thereby increasing the concentration of Sildenafil. Sildenafil in plasma; Simultaneous use of active ingredient Sildenafil with Cytochrome P450 3A4 stimulants such as Rifampicin will cause the plasma concentration of Loxmen to decrease; Antacids such as magnesium hydroxide, aluminum hydroxide do not affect the bioavailability of the active ingredient Sildenafil, so they can be used together.
6. Side effects of the drug Loxmen
Side effects of Loxmen may be as follows:
Systemic side effects of Loxmen: similar to other drugs, Loxmen may cause allergic reactions; On the cardiovascular system: Loxmen may increase heart rate; On the digestive system: Loxmen can cause vomiting, dry mouth...; On the metabolic system: Loxmen can increase thirst, increase blood glucose, increase blood sodium, increase urea, reflex hypoglycaemia. On the nervous system: Loxmen can increase tone, reduce reflexes; On the respiratory system: Loxmen may increase the cough reflex; On the eyes: Loxmen can cause dry eyes, glaucoma; Patients should inform the doctor about the undesirable effects encountered when using Loxmen.
7. Be careful when using Loxmen
Be careful when using Loxmen for the following subjects:
Patients with a history of myocardial infarction, stroke, arrhythmia within 6 months; Patients with heart disease; People with low blood pressure or high blood pressure; Retinal inflammation; Loxmen should be used with caution in patients with genital deformities, anatomical problems (angularity, fibrosis, Peyronie's disease), conditions that can lead to painful erections (cells) sickle cell, bone marrow pain, leukemia ); When the erection lasts more than 4 hours after taking Loxmen, Loxmen users need immediate medical intervention. The main active ingredient in Loxmen is Sildenafil, which is indicated for the treatment of erectile dysfunction in men. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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