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Lertazin 5mg is a medicine known for its use in the treatment of allergic cases such as seasonal allergic rhinitis, runny nose, sneezing, chronic allergic rhinitis, itchy nose, watery eyes. ... Let's learn about the use of lertazin 5mg in the following article to use the drug safely and effectively.1. What is lertazine 5mg?
lertazine is a drug belonging to the group of anti-allergic drugs with the main ingredient being levocetirizine dihydrochloride and excipients just enough for each tablet: Lactose monohydrate, microcrystalline cellulose, Colloidal anhydrous silica, Magnesium. piperazine, used to treat allergic cases such as urticaria, allergic rhinitis, seasonal allergies, .... Levocetirizine has a selective antagonistic effect in the H1 subtype. Several studies have shown that levocetirizine has a high potency for H1 receptors in humans. Levocetirizine has twice the affinity of cetirizine, and is cleaved from the H1-receptor with a half-life of 115 ± 38 minutes.
Several pharmacodynamic studies in study volunteers have demonstrated that levocetirizine at a dose of 1⁄2 has the same effect as cetirizine on hair and skin. In vitro experiments have shown that levocetirizine inhibits eotaxin-induced translocation of eosinophils across skin and lung cells. A pharmacokinetic study has shown that the three major inhibitory effects of levocetirizine 5 mg occurred during the first 6 hours of an allergic reaction to pollen, compared with 14 hours in patients receiving placebo, where levocetirizine inhibited release Like VCAM-1, regulate vascular permeability and reduce eosinophils. Clinical trials, including several randomized placebo-controlled double-blind studies, have been performed to clarify the safety and efficacy of levocetirizine in adult patients with seasonal allergic rhinitis.
2. What are the uses of lertazine 5mg?
Lertazin is used in the treatment of allergic cases caused by histamine such as chronic urticaria, seasonal allergic rhinitis, chronic allergic rhinitis, itchy nose, sneezing, runny nose, watery eyes, red eyes. The main ingredient lertazine is levocetirizine which is rapidly and widely absorbed after oral administration. Plasma drug concentrations peak after 0.9 hours of dosing. This peak state persists for 2 days after peaking. Peak concentrations were 270 ng/ml and 308 ng/ml, respectively, after a single dose and a repeat dose of the same amount of 5 mg the next day. The extent of absorption is not dose related and is not affected by food, but peak concentrations occur more slowly. Levocetirizine is not distributed in tissues and does not cross the vascular barrier. 90% of levocetirizine is bound to plasma proteins. The volume of distribution is 0.4 l/kg. 3. How to use lertazine 5mg.3. How to use lertazine 5mg
3.1. Dosage and how to use lertazine The drug is made in the form of tablets, 1 box of 3 blisters x 10 tablets. To be taken orally with a glass of water.
For adults and children 6 years of age and older: 5mg/day For the elderly: Adjust the dose in patients with renal impairment according to the severity of the disease, the patient's creatinine clearance must be assessed ( CLcr). CLcr (ml/min) is assessed by determining serum creatinine, consult your doctor about dosage before use. For children under 6 years of age: Lertazin is not recommended for use in children under 6 years of age. 3.2. Contraindications of the drug lertazin 5mg Do not use Lertazine in the following cases:
With people who are sensitive to the components of the drug (levocetirizine) and piperazine derivatives or other ingredients. People with severe renal impairment with creatinine clearance (CLcr) less than 10ml/min Notes for use :
Use with caution in patients with alcohol consumption Do not use the drug for people with rare hereditary problems of kidney disease. galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption due to lertazine 5mg film-coated tablets containing lactose Avoid using vehicles, driving while taking lertazine For pregnant and lactating women Levocetirizine is not teratogenic in animals, however, there are no adequate studies in pregnant women. Therefore, absolutely do not use for pregnant and lactating women. Do not use the drug for children under 6 years of age In case of overdose, it will cause somnolence in adults and children. There is currently no specific antidote to levocetirizine. In case of overdose, treat symptomatically and maintain treatment. If the duration of overdose is short, gastric lavage should be considered. It is ineffective if levocetirizine is excluded by dialysis. 3.3. Levocetirizine Drug Interactions 5mg There have been no drug interaction studies with Levocetirizine (including no studies with CYP3A4 enhancers). Studies on the racemic isomers of Cetirizine showed no interactions with Pseudoephedrine, Cimetidine, Ketoconazole, Erythromycin, Azithromycin, glipizide and diazepam. A slight decrease in cetirizine clearance (16%) was observed in the multiple-dose study with theophylline (400 mg once daily). Whereas theophylline tended to be unaffected by concomitant medications with cetirizine. The absorption of levocetirizine is not affected by food, but the rate of absorption is reduced. In some susceptible patients, the use of Cetirizine or Levocetirizine with alcohol or other CNS depressants may cause adverse effects on the central nervous system.
3.4. Side effects of lertazin 5mg Some side effects may occur when using lertazin 5mg:
Common: Dry mouth, fatigue, headache, somnolence Uncommon: Abdominal pain, rhinitis, pharyngitis , insomnia Very rare : Weight gain, abnormal liver function tests; Cardiovascular disorders: Palpitations, astigmatism; Respiratory disorders: Shortness of breath; Digestive disorders: Nausea; Skin and subcutaneous tissue disorders: Edema, pruritus, skin rash, urticaria; Immune system disorders: anaphylaxis, hepatitis Stop using the drug and inform the doctor about unwanted effects when using the drug or go to the nearest medical facility for timely handling.
3.5. Overdose, missed dose and management of Lertazine 5mg What to do in case of overdose Lertazine 5mg Prescription drugs require a prescription from a doctor or pharmacist. Over-the-counter medicines require a leaflet from the manufacturer. Carefully read and follow the exact dose indicated on the prescription or medication leaflet. When taking an overdose of Lertazine 5mg, it is necessary to stop taking it, immediately notify the doctor or pharmacist when there are abnormal symptoms
Note to handle in case of overdose Unusual manifestations of overdose need to notify the doctor or health care provider. In case of overdose of Lertazine 5mg, there are symptoms that require emergency: Call 911 immediately for guidance and help. Family members should bring medical records, all prescriptions/bottles of medicine that have been and are being used so that doctors can quickly diagnose and treat
What should I do if I forget a dose of Lertazine 5mg? Usually medications can be taken within 1-2 hours of what is prescribed in the prescription. Unless there are strict regulations on the time of use, the drug can be taken after a few hours when it is detected. However, if the time is too far from the time you need to drink, you should not take it, which can be dangerous for the body. It is necessary to strictly adhere to or consult a doctor before making a decision.
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