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Ledvir 90mg/400mg is indicated for the treatment of hepatitis C in adults with types 1, 4, 5, 6 with or without compensated cirrhosis. It is also indicated in patients with type 1 and advanced cirrhosis or patients with type 1 and 4 with or without cirrhosis, who have received a liver transplant.1. What is Ledvir?
Ledvir belongs to the group of drugs that treat parasites, infections, fungi and viruses. The drug is prepared in the form of film-coated tablets with the following ingredients:Ledipasvir (as Ledipasvir premix) 90mg; Sofosbuvir 400mg; The excipients are enough Ledvir tablets.
2. Indications for the use of Ledvir
Ledvir is indicated for the treatment of:
Hepatitis C in adults of types 1, 4, 5, 6 with or without compensated cirrhosis. Patients with type 1 and advanced cirrhosis; Patients with type 1 and 4 with or without cirrhosis have received a liver transplant. The drug is used together with Ribavirin.
3. Usage and dosage of Ledvir
How to use Ledvir:
Ledvir 90mg/400mg is taken orally. Ledvir should be taken at the same time of day, this will form a habit, avoiding the case of forgetting a dose. Take Ledvir before, during or after a meal. Because food does not affect the absorption of Ledvir. The patient should swallow the Ledvir tablet whole. Do not chew or crush the tablet as Ledvir has a bitter taste. Ledvir dosage:
The recommended dose of Ledvir is 1 tablet/time/day. Dosage for patients with hepatitis C without cirrhosis: The duration of treatment with Ledvir is 12 weeks. Treatment of hepatitis C with cirrhosis: The duration of treatment with Ledvir is 24 weeks with Ribavirin. When combining Ledvir with Ribavirin:
In people without decompensated cirrhosis, the dose of Ribavirin in the treatment regimen is calculated by weight (<75 kg using 1,000 mg of Ribavirin and ≥ 75 kg using 1,200 mg of Ribavirin). and is divided into 2 doses to be taken with a meal. For patients with decompensated cirrhosis, ribavirin is given at an initial dose of 600 mg daily in divided doses. If the initial dose of Ribavirin is well tolerated, it can be titrated to a maximum dose of 1,000 mg – 1,200 mg per day. Conversely, if the starting dose is not well tolerated, the dose should be reduced according to the hemoglobin concentration. The above Ledvir dose is for reference only. The specific dose will have to depend on the condition and stage of the disease in each person. Therefore, to get the right dose of Ledvir, you need to consult your doctor or pharmacist.
4. Side effects of Ledvir
You may experience some unwanted effects when taking Ledvir 90mg/400mg which are:
Fatigue ; Headache; Serious allergies. When experiencing side effects of Ledvir, patients need to stop using it and notify the doctor or go to the nearest medical facility for timely treatment.
5. Contraindications to the use of Ledvir
Ledvir is contraindicated in the following cases:
Do not use Ledvir concurrently with other drugs containing Sofosbuvir 400mg; Hypersensitivity to the components of the drug Ledvir. Children under 18 years of age should not use Ledvir because the effect on children has not been studied. Pregnant women should not use Ledvir. Breastfeeding women, if they must take Ledvir, must stop breastfeeding; Use Ledvir with caution in patients with hepatic and renal impairment.
6. Drug interactions
Drug interactions that can affect how each drug works or cause side effects. You should tell your doctor or pharmacist the list of medicines or supplements, vitamins that you are taking.
When using Ledvir concurrently with Tenofovir, Elvitegravirom, Emtricitabine must inform your doctor;
Do not use Ledvir concurrently with Rosuvastatin, Rifampin, Phenytoin, Carbamazepine and Tipranavir drugs, because it will reduce the effectiveness of antiviral treatment.
Above is information about Ledvir drug, patients need to carefully read the instructions on drug preservation information written on the package and the instruction sheet. Check the expiry date before taking Ledvir. When the medicine is no longer in use, it should be collected and disposed of according to the manufacturer's instructions.
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