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L-Stafloxin 500 is often indicated in the treatment of diseases related to bacterial infections. Complying with the indications, the dose of L-Stafloxin 500 will help patients improve the effectiveness of treatment and avoid unwanted side effects.
1. Composition of one L-Stafloxin 500 . tablet
Each L-Stafloxin 500 tablet will include 500mg of Levofloxacin and excipients just enough. The drug will be in the form of film-coated tablets.
2. What are the effects of L Stafloxin 500?
Levofloxacin contained in the drug L-Stafloxin is an antibiotic of the Quinolone group. It has the chemical structure of the L-isomer of Ofloxacin. It is from this structure that Levofloxacin possesses antibacterial activity. In addition, Levofloxacin also has the ability to kill bacteria by inhibiting Topoisomerase IV and DNA gyrase enzymes, thereby preventing bacterial DNA replication and recombination. Many bacteria, including those resistant to Aminoglycosides, Penicillins, Beta-lactams, and Macrolids, are very sensitive to Levofloxacin because it has a broad spectrum of antibacterial activity.
The list of some bacteria affected by L-Stafloxin are:
Gram-negative bacteria: H. influenza, Moraxella catarrhalis, Enterobacter cloacae, E.coli, Pseudomonas aeruginosa, Proteus mirabilis; Group of Gram-positive aerobic bacteria: Staphylococcus aureus meti-S, Streptococcus pneumoniae, Bacillus anthracis; Some other bacteria: Mycoplasma pneumoniae, Chlamydia pneumoniae, Propionibacterium, Peptostreptococcus, Fusobacterium. In addition, there will still be groups of bacteria that are not affected by the drug such as: Fluoroquinolone-resistant bacteria, Enterococcus faecium, Staphylococcus aureus meti-R.
L-Stafloxin 500 is used in the following cases:
Diseases such as pneumonia, chronic bronchitis, acute sinusitis; Prostatitis caused by bacterial invasion; Organs, organs such as skin, soft tissue or urinary tract infection.
3. Dosage and use of L-Stafloxin 500
Usage time will usually last from 7 to 10 days. Dosage for each case is as follows:
Prostatitis caused by bacteria will be treated with a dose of 5mg / time / day for 28 days; Uncomplicated urinary tract infections are treated in batches, each session lasts 3 days, the dose is 250mg/time/day; Patients with renal impairment will be adjusted dose depending on creatinine clearance (CC); Complicated urinary tract infections, nephritis, pyelonephritis with CC ≥ 20 will apply the dose of 250mg/24 hours, CC= 10 to 19 will apply the dose of 250mg/48 hours each time; The initial dose at all CC levels is 500mg, while the maintenance dose will vary depending on the CC level, such as: CC = 50 to 80: Use the normal dose. CC = 20 - 49 dose 250mg / time / 24 hours. CC= 10 - 19 dose 125mg/time/day. The drug is in the form of tablets, so it will be absorbed into the body through the oral route. Use 250-300ml of filtered water and drink the whole pill.
4. Cases where the use of the drug will not be recommended
People with hypersensitivity reactions to Levofloxacin and other substances contained in the drug or Quinolone antibiotics; People under 18 years old should not use the drug because it can cause toxicity on cartilage and joints; People with G6PD deficiency, epilepsy, tendon and muscle disease caused by fluoroquinolone use; Pregnant and lactating people are not recommended to use the drug.
5. Some side effects may occur when taking the drug
Common situations: Increased liver enzymes, insomnia, nausea, headache, diarrhea; Uncommon: Hyperbilirubinemia, vaginitis, allergies, rash, mood swings, genital candidiasis, dizziness, vertigo, anxiety; Rare: Anaphylaxis, blood pressure disturbances, heart rhythm disturbances, Quincke's edema, arthralgia, osteomyelitis, muscle weakness, Stevens-Johnson and Lyell syndrome, Achilles tendonitis, dry mouth, convulsions, confusion neuropathy, pseudomembranous colitis. In case of experiencing abnormal signs after using the ruler, you should contact the doctor in charge or a qualified person and find a solution.
6. Cases of drug interactions
Levofloxacin will be reduced absorption when used with iron salts, Antacids with magnesium or aluminum; The risk of convulsions is reduced when Levofloxacin is combined with Fenbufen, similar NSAIDs, Theophylline; Should not be used with Sucralfate because it will reduce the effectiveness of the drug. If it is necessary to take it, it should be taken 2 hours apart; When co-administered with Probenecid and Cimetidine, the clearance of the drug L-Stafloxin 24% and 34%; Increased effects of Warfarin on the body if used with L-Stafloxin; Hypoglycaemic drugs used with L-Stafloxin may cause blood sugar disturbances with a higher frequency, requiring close monitoring during treatment. Above is information about uses, dosage and precautions when using L Stafloxin 500. To ensure safety for health and maximize the effectiveness of treatment, patients need to take L-Stafloxin exactly as directed by the doctor, do not arbitrarily increase or decrease the dose or give prescriptions to others to use. .
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