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Kegynandepot is indicated in the treatment of vaginitis caused by fungi and sensitive bacteria such as Candida Albicans, Trichomonas, yeast... Let's learn about the uses and notes when using Kegynandepot through article below.
1. Uses of the drug Kegynandepot
Kegynandepot in the form of vaginal tablets contains the following active ingredients:
Metronidazol 500mg; Neomycin Sulfate 65,000IU; Nystatin 100,000 IU. Uses of the ingredients in 1 Kegynandepot tablet are as follows:
Metronidazol : An antibiotic belonging to group 5 - Nitro imidazol has a broad spectrum of action on protozoa such as E.histolytica, T.vaginalis, Giardia Lamblia and anaerobic bacteria. gas. The effect of the drug is by binding to the helical structure of DNA, breaking the structure and destroying bacterial cells. The effective concentration of Metronidazol on susceptible bacteria ranges from 8 micrograms/ml, the drug's effect is strong on protozoa, anaerobic bacteria and rarely develops drug resistance; Neomycin Sulfate: Aminoglycoside antibiotic with bactericidal effect through inhibition of bacterial protein synthesis. Neomycin is active against most gram-negative and gram-positive bacteria causing local or systemic infections. The drug is used topically in the treatment of skin infections, eye drops, ear drops, vaginal placement, abdominal cavity antiseptic before surgery; Nystatin: Antifungal antibiotic extracted from the culture of Streptomyces noursei. Drugs that kill or inhibit the growth of fungi. Nystatin acts by binding to sterols of fungal cell membranes, denaturing the cell membrane and changing the permeability of the cell membrane. The drug is very poorly absorbed from the gastrointestinal tract, so it is often used topically in the treatment of fungi, excreted in the feces as unmetabolized form. Kegynandepot is indicated in the following cases:
Vaginal infections with symptoms such as itching, inflammation, white discharge... caused by bacteria such as S.aureus, E.coli, Enterobacter... the protozoa such as Entamoeba hystolytica, Trichomonas vaginalis, Giardia Lamblia; Vaginal yeast infection caused by Candida Albicans.
2. Dosage of Kegynandepot
Kegynandepot is used to treat vaginitis with the dose prescribed by the doctor based on the symptoms and condition of the patient. The recommended dose of Kegynandepot is to put 1 tablet / time x 1-2 times / day, the recommended dosing time is 7-10 days (do not use more than 14 days).
How to use Kegynandepot as follows:
Clean and dry the intimate area before placing the medicine; Patients should lie on their back with knees bent; Before placing the tablet should be immersed in warm water for 2-3 seconds; Use 2 fingers to clamp the pill and push it deep into the vagina; Patients need to wash their hands with soap after applying the medicine and lie down for 15-20 minutes.
3. Side effects of Kegynandepot
Kegynandepot can cause some side effects as follows:
Skin: Rash, allergies, Stevens - Johnson syndrome; Gastrointestinal: Diarrhea, nausea, gastrointestinal disturbances, increased liver enzymes, increased salivation, increased bilirubin; Circulatory: Hemolysis, hematopoietic disorders; Nervous system: Disorientation, dizziness, deafness, nystagmus, headache, hot flushes, sweating. Patients need to stop using and notify the treating doctor in case of any unwanted effects while taking Kegynandepot.
4. Notes when using Kegynandepot
Contraindicated to use Kegynandepot drug in the following cases:
Patients are sensitive to any ingredient of Kegynandepot; Patients with a history of hypersensitivity to any drug of Aminoglycoside derivatives, Nitro - imidazole; Patients with myasthenia gravis because the Neomycin component in Kegynandepot has neuromuscular blocking effects, causing myasthenia gravis. Caution when using the drug:
Active ingredient Neomycin is highly toxic, so if not treated with Kegynandepot for a long time, Neomycin can cause respiratory depression, hearing loss leading to prolonged deafness. Metronidazole has an inhibitory effect on alcohol oxidizing enzymes, increasing the concentration of acetaldehyde. Therefore, do not use alcohol and other alcoholic beverages while taking the drug. For pregnant and lactating women: Active ingredient Metronidazol crosses the placental barrier and is excreted in breast milk, so it is not recommended to use Kegynandepot during the first 3 months of pregnancy and during pregnancy. breastfeeding time. For drivers, operating machines: Kegynandepot drug does not affect the patient's ability to drive and operate machines. Overdosage of the drug will lead to symptoms including diarrhea, vomiting, hearing loss, kidney dysfunction... In this case, the patient should be taken to a medical facility for timely treatment. time.
5. Drug interactions
Kegynandepot can cause some of the following interactions:
Concurrent use of Kegynandepot with Vitamin B12 loses the antifungal effect of the drug; Active ingredient Neomycin in the drug reduces the absorption of Digoxin, Phenoxymethyl, oral contraceptives; Neomycin and Metronidazol increase the anticoagulant effect of warfarin, cummarin and other neuromuscular blocking agents. Drug interactions occur that reduce the therapeutic effect of Kegynandepot, increasing the risk of unwanted effects. Therefore, before treatment with Kegynandepot, patients need to inform their doctor about the drugs and supplements they are using to ensure safety and effectiveness.
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