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Janumet XR 50mg one of the hormonal drugs marketed by prescription. Before taking the drug, you need to understand what Janumet XR is? Uses, dosage, usage... This information helps you use the drug safer.
1. What is Janumet XR?
Janumet XR 50mg is a prescription drug, used only when prescribed by a doctor. Classification of hormone drugs, hormones, list of drugs for diabetes.
Janumet XR 50mg has the main ingredients:
Metformin; Sitagliptin; Povidone; Hyproellose; Colloidal silicon dioxide; Sodium Stearyl Fumarate; Propul gallat; Polyethylene glycol; Kaolin; The drug is prepared in the form of film-coated tablets containing different concentrations clearly printed on the product packaging.
Film-coated tablets light blue, oval, 2 convex sides, one side smooth, one side engraved with number 78, with Janumet XR content 50mg/500mg; Oval green, convex, double-sided, green film-coated tablets, one side smooth, one side engraved with the number 80, content of 50mg/1000mg; Blue, oval, 2-convex, single-sided, film-coated tablets with the number 81 engraved with Janumet XR 100mg/1000mg Janumet XR 50mg are packaged in a bottle of 14 tablets or 28 tablets.
2. Uses of Janumet XR 50mg
Janumet XR 50mg contains active ingredients of the pharmacological group used for diabetics. It is often given with other oral hypoglycemic drugs.
Janumet XR 50mg used together with hypoglycemic drugs has the effect of increasing the ability to control blood sugar in cases of type 2 diabetes.
Sitagliptin phosphate itself is a drug for the treatment of oral hyperglycemia. By increasing the concentration of the hormone Incretin - an endogenous component, it helps to physiologically regulate the steady state of the homeostasis.
Ingredients Metformin hydrochloride - an active ingredient that lowers blood sugar by improving sugar tolerance in type 2 diabetic subjects. In addition, it also reduces both basal and postprandial blood sugar levels.
3. Indications to use Janumet XR 50mg
Janumet XR 50mg is indicated for subjects with type 2 diabetes. In addition, it needs to be combined with nutrition and exercise to control blood sugar.
4. Dosage – how to take Janumet XR 50mg
Janumet XR 50mg is taken orally according to a doctor's prescription. Swallow the tablet whole with filtered water, cooled boiled water, do not chew, crush or use with other beverages.
Dosage of Janumet XR 50mg is as follows:
4.1 Recommended Dosage According to the manufacturer, the recommended dosage is 100 mg of Sitagliptin and 2000 mg of Metformin. However, the use of drugs also depends on the current regimen of each individual.
4.2 Initial dosage According to the manufacturer's recommendations, the specific starting dose of Janumet XR 50mg is as follows:
4.3 In case of not taking Metformin The starting dose is 100mg sitagliptin/1000mg Metformin. Use once/day orally then monitor. In the case of uncontrolled blood sugar, no side effects, the dose can be increased after about 1-2 weeks. Metformin dosage based on efficacy and tolerability should not exceed 2000 mg/day.
4.4 In case of taking Metformin The recommended dose is 2 tablets / time / day for Janumet XR 50mg tablets should take 2 tablets / time / day.
4.5 For glycemic control failure with a single dose of Metformin In case of glycemic control failure with a single dose of Metformin, the recommended dose is 100mg of Sitagliptin along with the current dose of Metformin.
4.6 For the case of uncontrolled blood sugar with a single dose of Sitagliptin.
Note: Metformin dose can be adjusted for best blood control. The dose should be increased gradually to minimize the risk of side effects.
4.7 Case of switching from a combination regimen of Sitagliptin to Metformin A case of switching from a combination of Sitagliptin to Metformin using the starting dose of Janumet XR 50mg with the dose of sitagliptin and metformin being used.
For cases where blood sugar is not controlled by both drugs with any 2 of the 3 antihyperglycemic agents (sitagliptin, metformin or a sulfonylurea), Janumet XR 50mg with a total dose of 100mg/day.
In case blood sugar cannot be controlled by using both drugs with any 2 of the 3 anti-hyperglycemic agents (Sitagliptin, Metformin, PPARy agonist), the dose of Sitagliptin is 100 mg/day.
In case blood sugar is not controlled by using both drugs with any 2 of the 3 anti-hyperglycemic agents (Sitagliptin, Metformin, Insulin), the total dose of Sitagliptin is 100 mg/day.
5. Contraindications when using Janumet XR 50mg
Janumet XR 50mg is not used for the following subjects:
History of kidney disease, kidney dysfunction. May be based on serum creatinine or creatinine clearance is not normal due to cardiovascular diseases, myocardial infarction, sepsis; History of allergy or hypersensitivity to Sitagliptin phosphate, Metformin hydrochloride or any of the excipients contained in Janumet XR 50mg; Cases of acute and chronic metabolic acidosis; Just had an X-ray with radioactive iodide injection because of the risk of affecting kidney function If you belong to the above group of subjects, you should not use Janumet XR 50mg.
6. Precautions and warnings when taking Janumet XR
According to the manufacturer's recommendations, you need to pay attention to caution and some warnings when using Janumet XR 50mg:
Not for use in case of type 1 diabetes or diabetic ketoacidosis. People with pancreatitis need to stop taking Janumet XR 50mg; Some ingredients in Janumet XR 50mg can be eliminated by the kidneys. Therefore, when taking the drug, it is necessary to monitor renal function. Renal function should be assessed before taking Janumet XR 50mg; Hypoglycemia; Hypersensitivity reactions; Hypoxia, cardiovascular collapse due to causes such as acute congestive heart failure, myocardial infarction... should stop treatment with Janumet XR 500mg; Should stop using the drug when performing surgery; Patients with liver failure, poor liver function should not take the drug; Do not drink alcohol while taking the drug, because it can affect the lactate metabolism; If the patient is being treated for diabetes with a certain regimen but has infections, trauma, surgery, etc., it may happen again that the blood sugar cannot be controlled. At this time, it is necessary to stop taking Janumet XR 50mg. Can be used again after the acute episode. Antidiabetic drugs are not recommended for pregnant women; Elderly people need to be careful when using it, under the supervision of a doctor and regularly check kidney function. When using Janumet XR 50mg, it is necessary to be very careful, especially with medical history problems, allergies. Therefore, the drug should only be used when prescribed by a doctor or pharmacist.
7. Janumet XR 50mg . Interactions
What is Janumet XR? This is a drug used in the treatment of type 2 diabetes. The drug is used as prescribed and under the supervision of a doctor and pharmacist. Interactions Janumet XR 50mg include:
Sitagliptin and metformin: If concomitant use of this regimen does not change the effectiveness of treatment; Sitagliptin phosphate if used with drugs such as birth control pills, Glyburide, Metformin... can reduce the effect; Some other diabetes drugs, when used together with Janumet XR 50mg, can also reduce the effect such as blood cholesterol drugs, drugs for erectile dysfunction - impotence, medicines for high blood pressure, pain relievers - non-steroidal anti-inflammatory drugs, antidepressants,...; Metformin hydrochloride when used with Glyburide, Furosemide, Nifedipine may reduce the effect; Interactions when taking Janumet XR 50mg are quite complicated. Therefore, do not forget to inform your doctor or pharmacist of all the medicines you are taking or taking for a long time before having a prescription for Janumet XR 50mg.
8. Janumet XR 50mg . side effects
Janumet XR 50mg medicine can also cause unwanted side effects for users, including:
Digestive problems such as diarrhea, gastrointestinal infections...; Headache; Hypoglycaemia These side effects are common in about 5% of patients receiving Janumet XR 50mg. Do not forget to inform your doctor about side effects so that they can be handled promptly.
What is Janumet XR? This is a group of diabetes medications used by a doctor's prescription. Use with extreme caution because of the potential for interactions with many other drugs. Please consult your doctor, pharmacist if you have any problems while using Janumet XR 50mg.
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