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Glucovance 500mg/2.5mg drug contains metformin and glibenclamide belonging to the group of antidiabetic drugs in the form of film-coated tablets. Glucovance 500mg/2.5mg is indicated in the treatment of type 2 diabetes in adults. However, Glucovance 500 can cause some unwanted side effects. Therefore, before using Glucovance 500, patients need to carefully study the information and follow the instructions of the treating doctor.
1. Mechanism of action of the drug Glucovance 500
Glucovance 500 has an active ingredient called metformin, which has anti-hyperglycaemic effects and lowers basal plasma glucose levels after meals. This ingredient does not stimulate insulin secretion, so it does not cause hypoglycemia. Metformin stimulates glycogen synthesis in cells through its action on glycogen synthase. In addition, there are beneficial effects on lipid metabolism such as lowering total cholesterol, LDL,...
Glibenclamid has the effect of causing acute hypoglycemia by stimulating insulin release from beta cells. These two compounds have different mechanisms and sites of action that complement each other.
2. Indications and contraindications for the use of Glucovance 500
Glucovance 500 is indicated for use in the treatment of type 2 diabetes in adults with:
In combination with diet, training and single dose therapy with metfromin or glibenclamide not controlling blood sugar Apply An alternative regimen in the previous combination therapy with metformin and glibenclamide in patients with stable blood sugar and best controlled blood glucose levels.
3. Dosage and how to use Glucovance 500
The dose of Glucovance 500 may depend on the strength and frequency of use.
If used once a day, it can be used as a dose of 1 tablet in the morning. If used twice a day, a dose of 2 or 4 tablets can be used in the morning and evening. If using three times a day, use the dose of 3 tablets per day in the morning, noon and evening. It should be noted: The above recommended therapeutic dose for Glucovance 500 is for reference only. Therefore, before using Glucovance 500, patients need to be prescribed by a doctor.
If you miss a dose of Glucovance 500, take the missed dose as soon as you remember. However, if the interval between the missed dose of Glucovance 500 and the next dose is too close, skip the missed dose. Patients should not use a double dose of Glucovance 500, because it may cause an overdose. To overcome the situation of missing doses of Glucovance 500, you can set an alarm or ask a family member to remind you.
In case of accidentally using Glucovance 500 drug in excess of the prescribed amount and showing some unwanted signs such as abdominal pain, nausea and vomiting, diarrhea, fatigue, dizziness, low blood pressure pressure, difficulty breathing, drowsiness, itching....then you need to take the patient to see a doctor right away
4. Unwanted side effects when using Glucovance 500
Glucovance 500 may cause some unwanted side effects during treatment. However, for each case, Glucovance 500 may occur in varying degrees from mild to severe.
Some common side effects caused by Glucovance 500 include: taste disturbances, nausea and vomiting, diarrhea, abdominal pain, loss of appetite, increased creatinine levels, increased blood urea, liver porphyria. , porphyria manifested in the skin.... These side effects may occur at the beginning of treatment or after increasing the dose of the drug used. Usually these reactions can be transient or subside over time.
However, in some cases Glucovance 500 can cause serious unwanted side effects with rare reactions. These reactions may appear within minutes of using Glucovance 500 or may be longer within a few days. When serious side effects appear, such as: hyponatremia, leukopenia, thrombocytopenia, agranulocytosis, aplastic hemolytic anemia of bone marrow, pancytopenia, pruritus, urticaria... Patients should stop taking Glucovance 500 and seek immediate medical attention.
Although this is not a complete list of unwanted side effects of Glucovance 500, if the patient feels unusual signs during treatment, they should immediately notify the doctor or medical staff. .
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