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Itraxcop drug has the main ingredient Itraconazole, is an antifungal drug, used in the treatment of fungal infections in the lungs, pleural cavity, mouth, mucous membranes - skin or vagina. Let's find out what Itraxcop drug has and how to use it correctly through the article below.1. What is Itraxcop?
Itraxcop is made in the form of hard capsules with the main ingredients:Active ingredient: Itraconazole BP 100mg. Excipients: Non pareil seeds. Itraconazole is a triazole antifungal agent that is effective against susceptible fungi. The drug works through inhibition of cytochrome P450-dependent enzymes, thereby inhibiting the synthesis of ergosterol in fungal cell membranes. The spectrum of action of Itraconazole is slightly narrower than that of Ketoconazole, including: Candida spp, Blastomyces dermatitis, Histoplasma capsulatum, Malassezia furfur, Aspergillus spp, Microsporum spp and Trichophyton spp.
2. Indications and contraindications of Itraxcop
2.1. Indications for the drug Itraxcop
Use Itraxcop to treat fungus in the following cases:Candida infections in the mouth, throat and mucous membranes. Fungal infections of the skin such as tinea versicolor, tinea versicolor, inguinal skin, fingernails or ringworm. Nail fungus of hands, toenails Blastomycosis of lungs and extrapulmonary infections Visceral fungal infections such as Cryptococcus, Histoplasma, Sporothrix, Paracoccidioides, Blastomyces. Treatment for the prevention of recurrent latent fungal infections in AIDS-infected patients.
2.2. Contraindications to the use of Itraxcop
People with hypersensitivity to Itraconazole, other ozols or components of the drug Itraxcop. People who are being treated with Terfenadine, oral triazolam or Astemisol. Absolutely do not use Itraxcop drug to treat nail fungus for women who are or plan to become pregnant.3. Usage and dosage of Itraxcop
Usage:Itraxcop drug is used orally. Patients should take Itraxcop tablets whole, do not chew, break, crush because it can reduce the effectiveness of the drug. The drug should be used immediately after eating to increase potency.
Dosage:
Vaginal - vaginal candidiasis: There are 2 ways to use: 2 tablets / time, 2 times a day if treated for 1 day; or 2 tablets / time, 1 time a day if treatment for 3 days. Ringworm: 2 tablets/time, 1 time a day, treat for 7 days or 1 tablet/time, once a day, treat for 15 days. Highly keratinized areas such as palms, soles: 2 tablets / time x 2 times a day, treat for 7 days or 1 tablet / time, once a day for 30 days. Ringworm: 2 tablets / time, 1 time a day for 7 days treatment. Candidiasis in the mouth or throat: 1 tablet once a day, for 15 days. In case of patients with AIDS, neutropenia or organ transplant: 2 tablets once a day for 15 days. Onychomycosis: The patient was treated in courses of medication alternating between drug-free intervals. Patients with nail fungus need to drink 2-3 times, 7 days each, and 3 weeks apart. Dosage is 2 tablets / time, 2 times a day, morning - evening. The second way, in case the patient is on continuous treatment, the dose is 2 tablets once a day for 3 months. Visceral fungal infections: Aspergillus infections: 2 tablets once a day, for treatment from 2 to 5 months, if the disease does not respond or worsens, it can be increased to 2 tablets twice a day Candida: 1-2 tablet/times 1 time a day, treatment from 3 weeks to 7 months. Epidural Cryptococcus: 2 tablets once a day, for treatment from 2 months to 1 year. Cryptococcal meningitis: Initial dose: 2 tablets/time 2 times a day Maintenance dose: 2 tablets/time once daily. Paracoccidioides brasiliensis fungal infections: 1 tablet once a day for 6 months. Fungal infections Sporothrix schenckii : 1 tablet once a day for 3 months. Histoplasmosis: 2 tablets/time 1-2 times a day depending on the severity of the disease, average treatment for 8 months. Chromomycosis: 1-2 tablets/time, treatment for 6 months.
4. Notes when using Itraxcop
4.1. Itraxcop side effects
Some common side effects when using Itraxcop drug are headache, abdominal pain, indigestion, nausea. Rarely, cases of anaphylactic reactions such as skin rash, pruritus, angioedema, urticaria have been reported.4.2. Use caution when using Itraxcop in subjects
Pregnancy: In rat studies, Itraconazole in Itraxcop was dose-related and teratogenic at doses of 40-160 mg/kg daily. Currently, there are no studies on the safety of Itraxcop in pregnant women, use only when absolutely necessary and the benefits outweigh the risks. However, the use of Itraxcop is not recommended in women who are pregnant or planning to become pregnant. Lactation: Itraconazole is excreted in breast milk, so itraxcop should not be used in pregnant women. Children: The safety and efficacy of Itraxcop in children have not been established. Patients with disease or abnormal liver function: need to do liver enzyme tests before taking the drug and monitor during treatment. Instruct the patient to take Itraxcop with meals. If there are clinical signs of worsening liver disease, the drug must be discontinued or stopped immediately.5. Itraxcop drug interactions
Itraxcop drug can interact if used with the following drugs:The drug is metabolised by the cytochrome P4503A enzyme system: Increases drug concentration in blood plasma, prolongs treatment time, effectiveness and increases side effects. Diazepam, Midazolam, Triazolam Warfarin: Increased anticoagulant effect of Warfarin when used with Itraconazole, increasing the risk of bleeding, bleeding. Therefore, patients must monitor prothrombin time and reduce the dose of Warfarin when necessary. Calcium blockers: May cause tinnitus, edema. Cholesterol-lowering drugs such as Simvastatin, Pravastatin: increased plasma concentrations of these drugs, increased risk of side effects such as myositis, rhabdomyolysis. Above is all information about ingredients, usage, side effects and notes when using Itraxcop. Patients need to carefully read the instructions for use on the package of Itraxcop and strictly follow the doctor's instructions to achieve the best treatment results.
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