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Inotuzumab Ozogamicin is a monoclonal antibody created in the laboratory that aims to attach to cancer cells and prevent their proliferation. So what does Inotuzumab Ozogamicin work and how is it used? Please also Vinmec.com find out in the article below.
1. Uses of Inotuzumab Ozogamicin
As a monoclonal antibody Inotuzumab Ozogamicin is created to bind to targets found on specific types of cancer cells. This antibody will generate a signal that causes the immune system to attack the cell it is attached to, resulting in the immune system killing the cell.
Antibodies can act in a variety of ways including stimulating the immune system to kill cells, stop cell growth, or other functions necessary for cell replication
Drugs is an anti-CD22 antibody that combines with calicheamicin and a substance that helps bind the drug to bind the antibody part to the target cells, allowing it to enter and damage the cancer cell's DNA and kill it.
2. How to use Inotuzumab Ozogamicin
Drugs administered intravenously Dosage is based on the patient's height and weight Before taking you will be given acetaminophen, diphenhydramine, or corticosteroids to prevent drug-induced reactions.
3. Side effects when using Inotuzumab Ozogamicin
Hepatotoxicity
Inotuzumab can be toxic to hepatocytes, so liver function tests will be checked periodically while taking the drug. When you have symptoms such as yellowing of the skin, eyes, dark urine or persistent abdominal pain, notify your doctor for timely treatment. Inotuzumab can also cause a serious side effect called hepatic venous thrombosis, also known as hepatic sinus congestion syndrome. This is caused by a blockage in the flow of blood through the small veins of the liver. Symptoms of this syndrome can be seen as: jaundice, yellow eyes, enlarged liver, abdominal discomfort, fluid accumulation in the abdomen and weight gain, The effect of reducing white blood cell count
White blood cell count Decreased demand increases the risk of infection and infection. Please always maintain personal hygiene and clean surroundings, limit contact with people who have signs of flu, fever, cough, ... when fever (over 38 degrees Celsius) cough, sore throat, cold flu,... inform your doctor for treatment. Reducing the number of platelets
Taking the drug inotuzumab may increase the risk of bleeding by reducing the number of platelets, which are an important component in the blood clotting process of the body When nosebleeds, bleeding gums or have signs of blood in the stool, blood in the stool, please contact your doctor immediately Minimize the possible causes of bleeding, injury Do not use some drugs such as aspirin, other drugs anti-inflammatory non-steroid,... while taking inotuzumab Fatigue
This is one of the common symptoms during cancer treatment in general and inotuzumab in particular. gentle sets to increase health Effects on reproduction
The drug may affect fertility, disrupt menstrual cycles or reduce sperm production. Pregnant women should not become pregnant while either parent is being treated with this medicine because inotuzumab can cause birth defects in the unborn baby. Breastfeeding is not recommended while taking the drug or for 2 months after the last dose. In addition, some other side effects may occur such as: Decreased red blood cell count, nausea or vomiting, headache.
Some uncommon but very important side effects when treating cancer with inotuzumab include:
Side effects during infusion: may cause feelings of chills, fever, rash, or other medical problems. respiratory heart problems : this medicine can cause slow or irregular heartbeat called QT prolongation, if you have symptoms such as fatigue, dizziness or fainting tell your doctor. You will also be monitored electrocardiogram before and after taking the drug or when necessary. With the information on the article, hopefully, it has brought useful information to you before using Inotuzumab Ozogamicin.
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Reference source: oncolink.org
