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Iminam is an antibiotic, with the main ingredients being Imipenem and Cilastatin. Iminam is used to treat infections. To learn more about Iminam, read the information in the article below.
1. What is Iminam?
The Imipenem ingredient in the drug is a beta-lactam antibiotic with a very broad antibacterial spectrum. The drug interacts with a number of penicillin-binding proteins on the outer membrane of bacteria, inhibiting the synthesis of the bacterial cell wall. Imipenem is stable to bacterial beta-lactamases. Cilastatin is an inhibitor of dehydropeptidase I, an enzyme found in the renal tubules. Cilastatin is administered as the sodium salt in combination with Imipenem to prevent renal metabolism to biologically inactive and potentially nephrotoxic substances. Therefore, Cilastatin helps to increase the concentration of imipenem in the urine and prevent nephrotoxic effects. Cilastatin has no antibacterial effect and does not affect the antibacterial effect of imipenem.
2. What are the uses of Iminam?
Iminam is used to treat serious infections. Urinary tract infections, gynecological. Intra-abdominal and lower respiratory tract infections. Skin, soft tissue, bone and joint infections. Sepsis, endocarditis. Iminam is used in the treatment of hospital-acquired mixed infections, infections caused by mixed bacteria. Iminam should not be used by people who are sensitive to any of the ingredients in the formula, or to other beta-lactam antibiotics.
3. Usage and dosage of Iminam
3.1. How to use Iminam for intravenous infusion should not be used for direct infusion. Mix the contents of one vial with 100 ml of solution for infusion, the final concentration not exceeding 5 mg/ml. Infusion over 30 - 60 minutes. Monitor for convulsions. If nausea or vomiting occurs while using Iminam, the infusion rate should be reduced. 3.2. Dosage For adults
Intravenous infusion: Mild to moderate infections: dose 250mg - 500mg, every 6 - 8 hours (1g - 4g daily) Severe infections with moderately sensitive bacteria : 1g dose, every 6-8 hours. Maximum dose: 4g/day or 50 mg/kg/day Infusion dose of 250 - 500 mg in 20 - 30 minutes, infusion dose of lg in 40 - 60 minutes. Intramuscular: For mild to moderate infections only: dose 500 - 750 mg every 12 hours Intra-abdominal infections and more severe infections of respiratory tract, skin and gynecology: 750 mg dose The total intramuscular dose should not exceed 1,500 mg/day, requiring deep intramuscular injection into large muscle mass. In children under 12 years of age
Safety and efficacy of imipenem have not been established. Intravenous Iminam is used effectively at a dose of 15-25 mg/kg, once every 6 hours. In case of renal failure, reduce the dose of Iminam as follows:
Creatinine clearance 30 - 70 ml/min: 75% of the usual dose. Creatinine clearance 20 - 30ml/min: 50% of the usual dose. Creatinine clearance < 20 ml/min: 25% of the usual dose. Take an additional dose of Iminam after hemodialysis.
4. Side effects of Iminam
Reactions at injection site: pain, stiffness, erythema. Common side effects of Iminam are nausea, diarrhea, and vomiting. Uncommon side effects: hypotension, seizures, palpitations, pseudomembranous colitis, neutropenia, elevated liver enzymes, alkaline phosphatase and bilirubin. When overdosing Iminam, symptoms include: increased neuromuscular sensitivity, convulsions. It is necessary to stop taking Iminam immediately, treat symptoms, apply necessary supportive measures. Hemodialysis may be used to remove drugs from the blood.
5. Notes when using Iminam
Prolonged use of Iminam may lead to overgrowth of non-susceptible microorganisms. For the elderly, a lower dose is recommended, as renal function is reduced. Imipenem can cross the placenta. Iminam should only be used during pregnancy when the potential benefits outweigh the risks to the mother and fetus. Imipenem is excreted in human milk, so Iminam should be used with caution in this case.
6. Interactions of Iminam
Antibiotics other than beta-lactams and probenecid may increase the toxicity of Iminam.
Iminam is a medicine used to treat bacterial infections. However, when using it, it is necessary to strictly follow medical orders and under the close supervision of a doctor. If you still have questions about the information about Iminam, please contact your doctor immediately.
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