This is an automatically translated article.
Ikofate is indicated for the treatment and prevention of peptic ulcer disease. So what does Ikofate do? How to use and what should be noted when taking the drug to be safe and effective?
1. What is Ikofate?
Ikofate is a drug belonging to the gastrointestinal group. The main active ingredient in the drug contains Sucralfate, the content of 1g / 1 tablet.
Sucralfate is an active ingredient that has a protective effect on the stomach lining because it contains aluminum in it. Some studies have shown that taking a typical dose of Sucralfate results in about 002% of aluminum being absorbed.
When entering the body, Sucralfate together with Albumin, Fibrinogen form a complex that forms a barrier to prevent the impact of acids in gastric juice, bile salts, and pepsin. At the same time, the drug also inhibits the activity of pepsin, stimulates increased production of gastric mucus and Prostaglandin 2. From there, it helps to protect the cells of the gastric mucosa, stimulates the healing of scars caused by ulcerative lesions. cause.
2. Dosage of Ikofate
For patients with peptic ulcer disease:
The usual recommended dose is 1g/time x 4 times/day or 2g/time x 2 times/day. Take the medicine before eating and before going to bed. Note that the drug should not be given to patients for more than 2 weeks. It is recommended that each course of treatment should only last from 4 to 8 weeks depending on the severity of the patient's ulcer. Use the drug until the patient is concluded that the ulcer has healed completely on X-ray or endoscopic results. The course of treatment should be combined with proton pump inhibitors, H2 antihistamines and antibiotics to increase the effectiveness of treatment. For cases at risk of recurrent peptic ulcer disease, use Ikofate for prevention:
Use 1g/time x 2 times/day. Combine with antibiotics if necessary, especially in people with a history of Helicobacter Pylori infection. The maintenance dose should not exceed 6 months. For people with gastroesophageal reflux disease:
Dose 1g/time x 4 times/day. In children, calculate dose according to body weight: 40 - 80 mg/kg/day divided into 4 times. Note to take the medicine 1 hour before eating and before going to bed.
3. What is the effect of Ikofate?
Thanks to the main ingredient is Sucralfate, so Ikofate has the effect of protecting the lining of the stomach and esophagus, stimulating increased mucus secretion, and healing scars caused by ulcer lesions.
Indications for use of Ikofate with:
Treatment of patients with chronic peptic ulcer disease. Treatment of cases of gastroesophageal reflux disease. Prophylaxis of duodenal ulcer. Prophylaxis of peptic ulcers caused by stress factors. Contraindications to use Ikofate:
Patients with a history of hypersensitivity to any component of the drug. Patients with severe renal failure. Children under 4 years old. People with cerebral hemorrhage, severe heart failure.
4. Notes when using the drug Ikofate
Ikofate is only absorbed in a very small amount in the gastrointestinal tract, so there are very few side effects. Based on the frequency of clinical occurrence, side effects of Ikofate are divided into 3 main groups: common, uncommon and rare.
About common unwanted side effects of Ikofate, mainly constipation.
Less common side effects can be:
On the digestive system, the drug causes digestive disorders, vomiting, nausea, diarrhea, bloating, indigestion, dry mouth feeling. On the nervous system, the drug causes dizziness, insomnia. The drug Ikofate has the ability to cause drowsiness, back pain, headache ... In addition, the drug also appears red on the skin, causing itchy skin. Rare side effects:
Hypersensitivity reactions such as quincke edema, urticaria, facial edema, laryngospasm, dyspnoea... To limit the risk of undesirable effects, when used Ikofate drug should note a few things as follows:
Do not arbitrarily use the drug without a doctor's prescription or the guidance of pharmacists and medical staff. Arbitrarily changing the dosage increase or decrease can reduce the effectiveness of the treatment, making the condition worse. Ikofate may increase serum aluminum concentrations in patients with underlying renal impairment. Therefore, caution should be exercised when prescribing the drug. Ikofate is in the form of chewable tablets, so patients should be instructed to take it on an empty stomach. The best time to take the drug is before eating, before going to bed. When discovering the side effects of the drug, do not arbitrarily handle it, but immediately contact a specialist or the nearest medical facility for advice and treatment. For pregnant and lactating women: There are currently no specific studies to determine whether the drug passes into breast milk and whether the drug affects the fetus. Recommendations of the Ministry of Health, Ikofate should not be used in these cases. If necessary, consult your doctor before taking. The drug should not be used in children under 4 years of age. During the course of treatment, it is necessary to combine with a scientific nutritional diet, to increase vitamin and nutrient supplements. Limit eating hot spicy foods, alcohol, tobacco and other stimulants. As mentioned above, the drug has the potential to cause drowsiness, headache, dizziness. However, these symptoms are very rare, so the drug can still be used in patients who have to drive or operate machinery. If the patient is taking Antacids, they should be taken at least 1⁄2 hours apart from Ikofate because this group of drugs has the ability to reduce the adhesion of Ikofate. Some antibiotics such as Tetracycline, asthma medicine Theophyllin, H2-receptor antagonists... reduce the absorption of Ikofate in the body, so they need to be used 2 hours apart. If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the dose. Do not take a dose after double the dose to make up for the missed dose. Cases of drug overdose have not been recorded in clinical practice so far. If you accidentally take an overdose, contact your doctor immediately for help. Currently, due to unhealthy eating habits, along with problems of stress, bacteria, viruses, etc., peptic ulcers are happening more and more. Finding out information about Ikofate in the treatment of peptic ulcers will help you use the drug safely and effectively.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
