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Hytinon 500mg is manufactured by Korea United Pharm Inc (Korea) with the main active ingredient being hydroxyurea. The drug is applied in the treatment of hypertension, heart failure, hemodynamic stability after myocardial infarction. Please refer to the article below to get more useful information about the uses as well as notes when using this drug.1. Hytinon drug use
Hydroxyurea ingredient in Hytinon drug is used in the treatment of many cancers because it is a Urea derivative. The drug's mechanism of action inhibits DNA synthesis by inhibiting the incorporation of Thymidine into DNA. At the same time, this drug specifically inhibits the S phase of the cell cycle leading to cessation of progression at the border between the S and G1 phases.
Thanks to the above effects, Hytinon is often prescribed in the treatment of chronic myeloid leukemia. At the same time this drug as a combination therapy with radiation therapy to treat cervical cancer .
On the other hand, this drug is contraindicated for prescription in cases of allergy to any of its ingredients. Patients with severely reduced white blood cell count and anemia are also contraindicated.
2. Usage and Dosage of Hytinon
2.1. How to take Hytinon is in the form of capsules that should be taken orally. In case the patient cannot swallow the tablet, the powder can be mixed in a glass of water and taken immediately. Patients with chronic myeloid leukemia can receive ongoing treatment. Intermittent drug regimens are suitable for the treatment of cervical cancer. Hytinon should be used 7 days before starting radiation therapy. 2.2. Dosage Adults on continuous treatment are prescribed a dose of 20 - 30 mg/kg administered as a single daily dose. Adults on intermittent therapy are prescribed a dose of 80 mg/kg administered as a single dose every 3 days. It is rare for children to have this condition, so there is no treatment regimen for using Hytinon for this subject. Elderly patients have a lower adjusted dose of Hytinon. Patients with impaired renal function need a dose adjustment because Hytinon is eliminated by the kidneys. Hytinon overdose has been reported. At that time, the patient should be treated by gastric lavage, followed by supportive treatment for the cardiopulmonary system (if necessary). The patient may need to monitor the hematopoietic system or receive a blood transfusion.
During drug treatment, if you miss a dose, take the dose right away. You can skip the missed dose if it is almost time for your next dose. This is to avoid overdose causing dangerous side effects.
3. Hytinon side effects
Like many other cancer drugs, Hytinon can cause some side effects, negatively impacting the patient's health. Specifically:
Common side effects such as: myelosuppression, CD4 count, leukopenia, thrombocytopenia, decreased platelet count, anemia, loss of appetite, pancreatitis, nausea, vomiting, diarrhea , gastritis, constipation, mucositis, upset stomach, indigestion, abdominal pain, black stools, azoospermia, polyspermia... Some less common side effects such as: Skin cancer, hallucinations, disorientation, convulsions, dizziness, peripheral neuropathy, somnolence, headache, hepatotoxicity, elevated liver enzymes, cholestasis, hepatitis.... More rare side effects such as caseation. The above side effects, not all patients using Hytinon may also experience. If during the course of taking the drug, the patient encounters any abnormal signs suspected of being caused by Hytinon, they should also be cautious. In case, the symptoms do not improve, you should see a doctor for advice and medical support.
4. Note when using Hytinon drug
During the course of taking the drug, the patient should have a complete blood test. Do not prolong the use of the drug longer than prescribed because the drug can increase the risk of diseases such as erythrocytosis, secondary blood cancer. People who often operate machinery and drive should be careful when using Hytinon because the drug can cause drowsiness as a side effect. Pregnant women are not advised to take hydroxyurea Women who are breast-feeding, if deciding to take the drug, should discontinue nursing or discontinue the drug.
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