Uses of Slandom 8

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1. Uses of Slandom 8

Slandom 8 contains Ondansetron (as HCL salt) 8mg. Slandom 8 is produced in the form of film-coated tablets for oral administration, which is used to combat nausea/vomiting caused by chemotherapy or radiation therapy for cancer or vomiting after surgery. Slandom 8 is produced at SaVi Pharmaceutical Joint Stock Company and is highly effective by experts.

2. Indications and contraindications of the drug Slamdom 8

2.1. Indications Slandom 8 is indicated in cases of
Nausea and vomiting due to chemotherapy and radiation therapy for cancer; Prophylaxis of nausea and vomiting after surgery; Note: Physicians should give priority to prescribing Slandom 8 to young patients (under 45 years of age) because this subject is at high risk of extrapyramidal reactions when taking high doses of Metoclopramide and treatment with emetic chemicals. strong. However, Slandom 8 can still be used for the elderly; Slandom 8 should not be assigned to patients treated with chemicals with a low potential for emesis, such as Bleomycin, Busulfan, Cyclophosphamide dose less than 1000mg, Etoposide, 5–Fluorouracil, Vinblastin and Vincristin. 2.2. Contraindications Slandom 8 is not indicated for the following cases:
People with hypersensitivity to Ondansetron or other ingredients in the drug Slandom 8; Persons with a history of allergy to other 5HT3 receptor antagonists; Contraindications to the use of Slandom 8 with Apomorphine due to the risk of severe hypotension and loss of consciousness have been reported; The patient has a history of congenital QT prolongation syndrome.

3. Dosage of the drug Slandom 8

Nausea and vomiting caused by chemotherapy and radiation for cancer:
Adults and children 12 years of age and older: Vomiting side effects of chemotherapy treatments vary by specific chemotherapy and dose , in addition to the drug combination and the level of each patient. Therefore, the dose of Slandom 8 will vary from person to person, ranging from 8-32 mg/24 hours; The usual dose is 8mg (1 tablet Slandom 8 ), taken 30 minutes before chemotherapy or 1-2 hours before radiation therapy. Then, every 8-12 hours, continue to take a dose of 8mg (1 tablet of Slandom 8) maintained for 1-2 days after the end of therapy; For chemotherapy with drugs with strong emetic potential (such as high-dose Cisplatin): 24mg (3 tablets of Slandom 8) 30 minutes before starting therapy; Children 4-11 years: Take 4mg (1⁄2 Slandom 8 tablets) 30 minutes before chemotherapy or 1-2 hours before radiotherapy, repeat with the same dose after 4 and 8 hours. After that, children continue to take a dose of 4mg / time every 8 hours, continue 1-2 days after finishing treatment; Children under 4 years old: Slandom 8 is not suitable for this audience. Prophylaxis of nausea and vomiting after surgery:
Adults: Take a dose of 16mg (2 tablets of Slandom 8) 1 hour before anesthesia; Children under 18 years of age: Information on the use of Slandom 8 for the prevention of postoperative nausea and vomiting in children under 18 years of age is limited. Dosage of Slandom 8 for special subjects:
Liver failure: Need to reduce dose, maximum dose is 8mg/day for moderate and severe liver failure; Elderly: Dose does not need to be adjusted (same dose for adults); Renal impairment: No dose adjustment is required for Slandom 8. Studies on continued use of Slandom 8 after day one in this population are limited.

4. Notes when using Slandom 8

Serotonin syndrome with symptoms such as agitation, confusion, increased heart rate, muscle twitching or stiffness, fever, loss of consciousness or coma... can occur when Serotonin levels are accumulated in the body. may be at a high level. This syndrome usually occurs when Slandom 8 is combined with serotonin antagonists, but can still occur when Slandom 8 is used alone. Early diagnosis of Serotonin syndrome is important because the syndrome can be fatal if left untreated. Patients receiving concomitant Slandom 8 and selective Serotonin reuptake inhibitors or Serotonin and Norepinephrine reuptake inhibitors should be carefully monitored; Only use Slandom 8 for prophylactic purposes, not for therapeutic purposes because the use of Ondansetron is to prevent vomiting and nausea and not to treat vomiting; Only use Slandom 8 for the first 24 to 48 hours after chemotherapy. Research shows that Slandom 8 does not increase effectiveness in cases of late onset nausea and vomiting; The clearance of Ondansetron is decreased and the half-life of Slandom 8 is increased in patients with hepatic dysfunction, therefore dose reduction is required in cases of severe hepatic impairment (Child-Pugh C); Hypersensitivity reactions to Slandom 8 have been reported in cases of hypersensitivity to other selective 5HT3 receptor antagonists; Do not use Slandom 8 for pregnant women and nursing mothers; Slandom 8 may cause adverse effects such as dizziness, fatigue... Therefore, caution should be exercised when assigning it to people who drive, operate complex machinery or do jobs that require alertness.

5. Side effects of the drug Slandom 8

Slandom 8 may cause the following common side effects:
Central nervous system: Headache, fatigue, fever, anxiety; Gastrointestinal: Constipation or diarrhea; Dermatology: Itching, rash; Genitourinary - urological: Genitourinary disorders, urinary retention; Liver: Increased liver enzymes ALT, AST; Respiratory failure, hypoxia. Some uncommon and rare side effects of Slandom 8:
Dizziness; Abdominal cramps, dry mouth; Muscle weakness; Hypersensitivity or anaphylaxis; Tachycardia, arrhythmia, hypotension; Seizures; Rash, bleeding under the skin; Hypokalemia; Increased serum bilirubin; Bronchospasm, shallow breathing, wheezing; Chest pain, hiccups.

6. Slandom 8 . Drug Interactions

Ondansetron in Slandom 8 does not induce or inhibit the cytochrome P450 enzyme system, but is metabolized by many liver enzymes, including CYP3A4, CYP2D6, and CYP1A2. Therefore, drugs that induce or inhibit these enzyme systems (such as Cyproterone, Deferasirox, Peginterferon Alfa-2b, Barbiturates, Carbamazepine, Rifampin derivatives, Phenytoin, Phenylbutazone, Cimetidine, Allopurinol, Disulfiram, Alfuzosin, Artemether, Ciprofloxacin.. may alter the clearance and half-life of Slandom 8 when administered concomitantly, but no dose adjustment is necessary; caution should be exercised when administering Slandom 8 with drugs that prolong the QT interval and/or cause disturbances. Ondansetron in Slandom 8 prolongs the QT interval, so concomitant use of QT-prolonging drugs may increase the risk of toxicity. Concomitant use of Slandom 8 with cardiotoxic drugs (anthracyclines or Trastuzumab), antibiotics (such as erythromycin), antifungal drugs (such as Ketoconazole), antiarrhythmics (such as Amiodarone), and beta-blockers (such as Atenolol or Timolol) may increase the risk of dysrhythmic side effects. heart rate; Avoid concomitant use of Slandom 8 with drugs Apomorphine, Artem ether, Dronedaron, Lumefantrine, Nilotinib, Pimozide, Quetiapine, Quinine Tetrabenazine, Thioridazine, Tamoxifen, Vandetanib, Vemurafenib, Ziprasidone; Concomitant use of Slandom 8 with selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors may increase the risk of serotonin syndrome; Concomitant use of Apomorphine with Slandom 8 due to an increased risk of severe hypotension and loss of consciousness; Slandom 8 may decrease the pain-relieving effects of Tramadol.

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