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Hycamtin 4mg is a powder for intravenous infusion, used in the treatment of metastatic ovarian carcinoma and small cell lung cancer. Using Hycamtin 4mg exactly as prescribed by your doctor will help you ensure your health and maximize the effectiveness of your treatment.
1. What is Hycamtin 4mg?
Hycamtin 4mg is a cancer treatment and affects the immune system. With the main active ingredient is Topotecan, Hycamtin 4mg is prepared as a powder for solution for intravenous infusion.
Hycamtin 4mg is manufactured and packaged in boxes of 1 vial or 5 vials. Main ingredients: Topotecan in the form of Topotecan HCl 4mg and excipients.
Topotecan is an anti-cancer drug by killing or limiting the growth of cancer cells in the human body. Hycamtin 4mg drug with the main ingredient Topotecan is used in the treatment of small cell lung cancer and ovarian carcinoma. Usually, Hycamtin 4mg will be used after the patient's initial chemotherapy has not worked.
In uterine carcinoma, Hycamtin 4mg is used in combination with Cisplatin for the treatment, after being determined by cytogenetics to stage IV-B recurrent or not curable with surgery and radiation. treat.
2. Effects of Hycamtin 4mg
Hycamtin 4mg works to treat cancer in patients by killing or slowing the growth of cancer cells. At the same time, Hycamtin 4mg also easily reduces the function of bone marrow, which can lead to the risk of reducing red blood cells, white blood cells and platelets of the patient.
3. Indications for taking Hycamtin 4mg
The drug is indicated in the treatment of the following conditions:
Metastatic carcinoma of the ovary (provided that first-line chemotherapy fails) Small cell lung cancer after failure of first-line chemotherapy.
4. Contraindications to taking Hycamtin 4mg
Patients who are allergic to Topotecan Pregnant or lactating women. Patients with bone marrow failure (neutrophils < 1.5x109/L and/or platelets < 100x109/L).
5. Dosage of Hycamtin 4mg
Before the first course of treatment with Hycamtin 4mg, the patient must have neutrophils ≥ or equal to 1.5x109/L, platelets ≥ 100 x 109/L, hemoglobin ≥ 9g/dL.
Dosage for patients with ovarian or small cell lung carcinoma:
Initial dose: 1.5mg/m2/day, administered intravenously for 30 minutes daily, for 5 consecutive days. Start with 1 course for 21 days, with a minimum of 4 infusions. Subsequent doses should be re-administered if neutrophils ≥ 1x109/L, platelets ≥ 100x109/L, hemoglobin ≥ 9g/dL after transfusion if necessary. Dosage for patients with cervical cancer:
Only start when the patient has a blood creatinine level ≤ 1.5mg/dL. Initial dose: 0.75 mg/m2, intravenous infusion 30 minutes daily on the day for 3 days. After 3 days of infusion of Hycamtin 4mg, administer an intravenous infusion of 50 mg/m2 Cisplatin. Repeat the above course every 21 days for 6 sessions or until the disease improves. Subsequent doses: should not be re-administered unless neutrophil levels ≥ 1.5x109/L, platelets ≥100x109/L and hemoglobin ≥9g/dL (after blood transfusion if necessary).
6. Hycamtin 4mg . side effects
Common side effects when taking Hycamtin 4mg:
Rash, loss of appetite, nausea, vomiting, digestive disorders; Patchy hair loss; Sepsis, neutropenia/platelet count, anemia. Rare side effects when using Hycamtin 4mg:
Hyperbilirubinemia, itching. Rare (dangerous) side effects:
Anaphylaxis, edema, urticaria, interstitial pneumonia. Some other side effects when taking Hycamtin 4mg medicine have not been recorded with a specific frequency:
Severe bleeding associated with thrombocytopenia, ulcers causing perforation of the gastrointestinal mucosa (gastrointestinal perforation).
7. Note when taking Hycamtin 4mg
For patients with poor response, when taking Hycamtin 4mg, it is easy to cause fever and sepsis. You should immediately go to a qualified medical facility for timely treatment. Hycamtin 4mg drug includes quite a few side effects, so patients need to clearly declare their allergy history to the doctor giving the indication. In patients with a history of interstitial lung disease, pulmonary fibrosis or lung cancer, Hycamtin 4mg has been associated with these conditions and may pose a risk of death. The toxicity of Hycamtin 4mg to blood cells needs to be tested regularly, because Topotecan in Hycamtin 4mg can cause leukopenia in general and neutrophils in particular. Hycamtin 4mg is a cancer treatment drug, so it should be used with extreme caution as prescribed by a doctor. During the course of treatment, if any abnormal symptoms appear due to the use of Hycamtin 4mg, you need to notify the treating doctor for timely treatment.
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