This is an automatically translated article.
Hycamtin 0.25mg is an orally administered cytotoxic, anti-tumor drug, for the treatment of recurrent small cell lung cancer. The drug has the potential to cause many adverse reactions, so it should be used with caution under the close supervision of a doctor.1. Uses of Hycamtin 0.25mg
Hycamtin drug Novartis 0.25mg is registered by Novartis Pharma Services AG of Italy. With the main active ingredient of Hycamtin 0.25mg is Topotecan (as Topotecan HCl) 0.25mg is prepared in the form of hard capsules.Topotecan is used for anti-tumor, the anti-tumor effect of topotecan is related to its inhibitory effect on topoisomerase-I, an enzyme closely involved in DNA replication. Topotecan inhibits topoisomerase-I by stabilizing the covalently bound complex of the enzyme and cleavage DNA (an intermediate of the catalytic mechanism). The cytological consequence of topoisomerase-I inhibition by topotecan is the disruption of the protein-binding DNA single-stranded DNA.
2. Indications and contraindications of Hycamtin 0.25mg
2.1. Point
Hycamtin 0.25mg is indicated in the treatment of recurrent small cell lung cancer.2.2. Contraindications
Do not use Hycamtin 0.25mg in the following cases:Patients with a history of severe hypersensitivity reactions to any of the ingredients. Pregnant women and lactating women. Having severe myelosuppression with subclinical manifestations of neutrophils less than 1.5x 109/L or platelets less than 100x109/L.
3. Dosage and how to use Hycamtin
3.1. How to use
The drug is taken orally, it is necessary to swallow the tablet whole with water, do not chew it or let it dissolve in the mouth. The drug can be taken with or without food because food does not affect the absorption of the drug. When taking the drug, do not open the tablet, do not let the powder in the tablet get into the eyes and skin. If affected, immediately wash the medicine with water within 15 minutes and if it comes into contact with the skin, wash your hands with soap and water immediately. Consult a doctor if the medicine gets into skin or eyes.3.2. Dosage
Adults:The recommended initial dose of the drug is 2.3 mg/m2/day, taken for 5 consecutive days, starting on a 21-day course. Subsequent doses: The drug should not be re-administered unless neutrophils ≥ 1x109/L, platelets ≥ 100x109/L and Hb ≥ 9g/dL (after blood transfusion if necessary). If the patient has grade 3 and grade 4 diarrhea, the dose should be reduced by 0.5mg/m2/day, if diarrhea grade 1, 2 take the drug as usual. Children: Due to limited efficacy and safety data in pediatric patients, Hycamtin 0.25mg is not recommended for children.
Elderly: No overall difference in efficacy was observed between patients over 65 years of age and younger adult patients. However, there have been reports of patients over 65 years of age receiving oral topotecan having an increased incidence of drug-related diarrhea compared with patients younger than 65 years of age.
Renal impairment: No dose adjustment is required in patients with creatinine clearance between 50 and 80 mL/min. The recommended single oral dose of topotecan in patients with small cell lung cancer with creatinine clearance between 30 and 49 ml/min is 1.9 mg/m2/day for five consecutive days. If tolerated, the dose can be gradually increased up to 2.3 mg/m2/day in the next cycle.
Not recommended if creatinine clearance is less than 30ml/min
Hepatic impairment: There are no specific studies on the pharmacokinetic effects of oral topotecan in patients with hepatic impairment.
4. Undesirable effects when taking Hycamtin
When taking the drug you may experience unwanted effects, including:Very common side effects: Infection; Anemia, fever due to neutropenia, decreased white blood cell count, neutropenia, thrombocytopenia; Loss of appetite (may be severe); Diarrhea, nausea, and vomiting can all be severe, with abdominal pain, constipation, and stomatitis; Asthenia, fatigue, fever; hair loss Common side effects: Sepsis; Decrease in total platelet count; hypersensitivity reactions, including rash; Hyperbilirubinemia; discomfort Rare: Interstitial lung disease; Heavy bleeding (associated with thrombocytopenia); Neutropenic colitis, including potentially fatal neutropenic colitis, has been reported to occur as a complication of topotecan-associated neutropenia; Inform your doctor about unwanted effects when using the drug, mild adverse effects only need to be monitored and may require discontinuation of the drug. In case of severe hypersensitivity or allergic reaction, supportive treatment should be instituted.
5. Note when using Hycamtin 0.25mg
Hycamtin 0.25mg should be used under the direction of physicians experienced in the treatment of potentially cytotoxic drugs, because the drug has a high risk of harm and should be closely monitored. When using the drug, it is necessary to consider the possibility of neutropenic colitis if there are manifestations of fever, neutropenia, and abdominal pain corresponding to colitis. To receive treatment because there is a risk of death from the disease. Use with caution in patients with a history of interstitial lung disease, pulmonary fibrosis, exposure of the thorax to radiation, and the use of drugs that are toxic to the lungs or cytotoxic factors. Interstitial pneumonitis has been reported due to drug use and fatal cases have been reported. Severe diarrhea that can occur with oral medications requiring hospitalization has been reported with oral medications. A physician should be informed of any history of diarrhea prior to administration. When diarrhea occurs, rehydration and electrolytes may be necessary and medication may need to be stopped. Because of the risk of diarrhea that can be fatal due to dehydration and electrolytes, if diarrhea is present, seek medical attention immediately. As with other cytotoxic drugs, Hycamtin causes severe myelosuppression, and deaths from thrombocytopenia have been reported. Blood cell counts should be checked regularly while taking the drug. This medicine has a risk of harm to the fetus, not for pregnant women. Make sure to use effective contraception while taking the drug, avoid the risk of pregnancy, and if pregnant or in doubt, notify your doctor immediately. Drug Interactions: The drug has the potential to interact with other cytotoxic drugs. Storage: Store the medicine in a sealed package, in a cool place, away from sunlight, the storage temperature is from 2 - 8 degrees Celsius, do not freeze and need to keep the medicine out of the reach of children. , pet. Hycamtin is a cancer treatment drug, indicated for taking Hycamtin when it has not been prescribed by an experienced doctor. You should consult your doctor carefully and read the medication instructions carefully before taking the medicine.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
