This is an automatically translated article.
Humira is a drug that works to reduce pain, reduce inflammation for patients with chronic autoimmune arthritis. The use of the drug needs to be controlled and closely monitored by a doctor, because there is a risk of many effects on the body.
1. What is Humira?
What is Humira? Humira 40mg medicine has the main ingredient Adalimumab 40mg/0.8ml, available in syringes containing 0.8ml of medicine.
Adalimumab is a recombinant human anti-TNF-α IgG1 monoclonal antibody that blocks the inflammatory activity of TNF-α and helps reduce leukocyte migration. It has anti-inflammatory and pain-relieving effects.
2. Uses of Humira
Humira is indicated for use in the following cases:
Rheumatoid arthritis: It can be used alone or in combination with methotrexate or other non-biologic DMARDs to reduce severe clinical signs, inhibit progression of structural damage and improved physical function in adult patients. Juvenile Idiopathic Arthritis: It is indicated, alone or in combination with methotrexate, for the relief of signs and symptoms of idiopathic arthritis in severely active adolescents. 4 years old and up. Psoriatic arthritis: Helps relieve signs and symptoms, inhibit progression of structural damage, and improve physical functions in adult patients with active psoriatic arthritis. Ankylosing Spondylitis: This medication is indicated for the relief of signs and symptoms in adult patients with ankylosing spondylitis. Crohn's Disease in Adults: Used to provide clinical remission in adult patients with moderately severe active Crohn's disease who have responded inadequately to conventional therapy. Ulcerative colitis: Helps reduce clinical signs in adult patients with moderate to severe ulcerative colitis who have had an inadequate response to immunosuppressants such as corticosteroids, azathioprine, or 6-mercaptopurine. Plaque psoriasis: It is indicated for the treatment of moderate to severe chronic plaque psoriasis. This medicine should only be given to patients who will be closely monitored and have regular follow-up visits with their doctor.
3. Dosage and how to use Humira
How to use: The drug is administered by subcutaneous injection. Note on injection:
Take the injection pen out of the refrigerator, shake well and check the color inside the pen. If it is cloudy or has particles, it should not be used. When injecting, hold the injection pen upright with the disinfected skin area, press the injection button above when you hear a very clear click. Relying on the dosing window helps to judge whether the injection has been completed or not. Dosage: The drug is taken according to the prescription and strictly controlled by the doctor. Here are the dosages you can refer to.
Adult patients, the elderly:
Rheumatoid arthritis: Use at a dose of 40mg, every 2 weeks, can continue to take Methotrexate. In monotherapy 40mg weekly if poor response. Psoriatic arthritis, ankylosing spondylitis: 40 mg once every 2 weeks; Severe Crohn's disease: In the first week take 80 mg, the second week take 40 mg. In case if a faster response is required, the first week: 160 mg (2 or 4 times a day for 2 consecutive days), the second week at 80 mg, then 40 mg every 2 weeks. once. Adolescents 13-17 years old:
Idiopathic polyarthritis: 40mg every 2 weeks. Clinical response is usually achieved within 12 weeks of treatment with the drug, and whether to continue treatment or not should be carefully considered in patients who do not respond during this period of treatment.
4. Contraindications of the drug Humira
Do not use Humira in the following cases:
The patient is sensitive to any of the ingredients. Active tuberculosis Severe infections such as sepsis, opportunistic infections Moderate to severe heart failure (NYHA class III/IV).
5. Side effects of the drug Humira
When taking the drug you may encounter some side effects such as:
Very common side effects: Pain at the injection site; Upper respiratory tract infection; Increased creatine phosphokinase; Headache; Rash; Sinusitis ; Common side effects: Nausea; Urinary tract infections; Stomachache; Hyperlipidemia; Backache; Increased blood cholesterol; Blood in urine; Hypertension; Alkaline phosphatase increased; Uncommon side effects: Allergic reactions; Hematological disorders such as leukopenia, thrombocytopenia, aplastic anemia; Rare: Liver failure, hepatitis; Sarcoidosis; Merkel cell carcinoma (neural cell carcinoma of the skin); optic neuritis, Guillain-Barré syndrome; Stroke; Interstitial lung disease, including pulmonary fibrosis, pulmonary embolism; Stevens Johnson syndrome, cutaneous vasculitis, erythema multiforme, new or worsening psoriasis; alopecia, lichen skin reaction; Systemic vasculitis, deep vein thrombosis; You should tell your doctor about any side effects you experience while taking this medicine.
6. Notes when using Humira
Treatment should not be initiated in patients with active infections, including chronic infections or newly developed infections. History of exposure to tuberculosis, travel in an area at high risk of tuberculosis or fungal disease.
The benefits and risks should be weighed before use in the following people:
People with a history of recurrent infections, medical conditions that may predispose them to infection, including concomitant use of immunosuppressive drugs . Risk of hepatitis B virus reactivation in chronic HBV carriers; There is a high risk of lymphoma, leukemia and other malignancies. Previous or recent demyelinating disorders of the central or peripheral nervous system. If anaphylaxis, severe allergic reactions, blood abnormalities, symptoms suggestive of a lupus-like syndrome occur, and anti-double-stranded DNA antibodies are positive, the drug should be discontinued and monitored closely. .
Do not give live vaccines to young children within 5 months of the last injection of adalimumab; People of childbearing age should have effective birth control methods to prevent pregnancy and for 5 months after taking the last dose. Use of drugs for mothers during pregnancy and lactation: Due to unknown effects on the fetus and nursing infant. Therefore, it is best not to use drugs. Using drugs has a high risk of infection, so patients need to take measures to actively prevent the risk of infection. Avoid contact with people with infectious diseases. Drug interactions: Some drugs can cause interactions such as Anakinra, abatacept: increasing the risk of infection, including the risk of serious infection and other potential pharmacological interactions.
Storage: The injection should be stored in the refrigerator, at a temperature of 2-8oC (36-46oF); do not allow the medicine to freeze; Protect from light and keep out of reach of children.
Above is information about Humira medicine, which is prescribed by a doctor and only used in people who can visit regularly.
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