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Greatcet is a combination pain reliever used to treat moderate to severe pain that does not respond to conventional pain relievers. Let's find out the ingredients and uses of the drug through the article below.1. What is Greatcet?
The main ingredient of Greatcet 325 is Acetaminophen (paraceramol) 325mg, Tramadol hydrochloride 37.5mg
Paracetamol is a non-steroidal antipyretic analgesic. Paracetamol (acetaminophen or N - acetyl - p - aminophenol) has analgesic and antipyretic effects similar to aspirin, but without the anti-inflammatory effect.
Paracetamol with therapeutic doses rarely affects the cardiovascular and respiratory systems, does not change the acid - base balance, does not cause irritation, damage or bleeding in the stomach as when using salicylates. Because paracetamol does not affect systemic cyclooxygenase, but only affects cyclooxygenase/prostaglandin of the central nervous system. Paracetamol has no effect on platelets or changes in bleeding time. On research, Paracetamol reduces body temperature in febrile patients, but rarely lowers body temperature in normal people. The drug acts on the hypothalamus causing hypothermia, heat loss due to vasodilation and increased peripheral blood flow.
Tramadol Tramadol is an opioid pain reliever that acts on the central nervous system. The drug acts by at least two mechanisms and when used long-term can be as addictive as morphine. When evaluated in laboratory animals, the combination of tramadol and paracetamol was found to have a synergistic effect.
2. Uses of the drug Greatcet
Greatcet is indicated for use in the treatment of moderate to severe pain such as toothache, postoperative pain, cancer pain... that have not responded to monotherapy.Contraindications:
Patients do not use the drug for cases of hypersensitivity to Tramadol, Acetaminophen and its components. Greatcet is not indicated for pregnant and breastfeeding women. Acute alcohol poisoning. Poisoning with drugs affecting the central nervous system such as sleeping pills, analgesics, psychotropic drugs. Severe acute respiratory failure. Risk of coma due to head trauma, intracranial disease. Are taking an MAOI or have used it within the previous 14 days. Patients with chronic anemia or severe heart, lung, kidney, or liver disease Patients with peptic ulcers or severe hemodynamic disorders. Patients with glucose - 6 - phosphate dehydrogenase deficiency. Patients with uncontrolled epilepsy. Exacerbation of asthma caused by aspirin or other non-steroidal anti-inflammatory drugs.
3. Dosage and how to use Greatcet
3.1 How to use The drug is taken orally, taking it with water before or after eating is okay.
3.2 Dosage Adults and children over 12 years old: Take 1-2 tablets each time, at least 4 to 4 days apart. 6 hours and should not take more than 8 tablets in 1 day. Children (under 12 years): The safety and effectiveness of Greatcet have not been studied in children. So do not use for this object. Elderly (over 65 years): There was no difference in safety between users over 65 and younger users. Patients with renal impairment: Do not use in patients with severe renal impairment (creatinine clearance less than 10ml/min). For patients with mild to moderate renal impairment, the interval between doses is 12 hours. Patients with hepatic impairment: do not use in severe liver failure. If liver failure is mild and moderate, distance and use caution. Overdose: The clinical manifestation of an overdose of Greatcet may be signs or symptoms of tramadol, paracetamol or both.
Tramadol: Serious consequences of an overdose of tramadol can be respiratory failure, coma, convulsions, cardiac arrest and death. Paracetamol: When taking very high doses paracetamol can cause liver toxicity for patients. Early symptoms that can occur after liver damage from paracetamol overdose include: gastrointestinal irritation, irritability, loss of appetite, nausea, vomiting, paleness, sweating. Symptoms of severe hepatotoxicity may appear 48 to 72 hours after taking the drug. When taking a high dose or having symptoms of suspected overdose, it is necessary to immediately go to a medical facility for timely treatment and treatment.
4. Undesirable effects when taking Greatcet
When taking the drug, unwanted effects may occur including:
The most frequent side effects are effects on the central nervous system and digestive system. The most common are nausea, dizziness, drowsiness.
Some less frequent side effects:
Asthenia, fatigue, strong emotions. Central and Peripheral Nervous System: Headache, shivering. Digestive system: Abdominal pain, constipation, diarrhea, dyspepsia, bloating, dry mouth and vomiting. Psychiatric disorders: anxiety, confusion, agitation, insomnia or restlessness. Itching on the skin, rash, increased sweating. When taking the drug, if abnormal signs occur, you should notify your doctor for advice and handling.
5. Notes when using Greatcet
Some things to keep in mind when taking Greatcet:
Use caution when using the drug, because there is a risk of convulsions when tramadol is used concomitantly with SSRIs (serotonin reuptake inhibitors), TCAs (compounds). tricyclics), Opioids, MAOIs, tranquilizers or drugs that lower the seizure threshold. Use with caution, because there is a risk of respiratory depression in patients at risk of respiratory failure. Addiction and withdrawal symptoms occur upon discontinuation of the drug. Caution should be exercised when using tramadol in patients with opiate addiction because of the potential for relapse. This drug should not be used concurrently with alcohol, as the risk of hepatotoxicity is increased. Use with caution in alcoholic patients because of the risk of hepatotoxicity. Do not take with other drugs that also contain similar ingredients such as paracetamol or tramadol. Must comply with the use of pain relievers according to the World Health Organization. When conventional pain relievers are ineffective, narcotic pain relievers such as Tramadol or morphine are used. Drug interactions: Some drugs can cause drug interactions with carbamazepine that reduce the analgesic effect of tramadol. Concomitant use with warfarin class of drugs may cause an increase in the INR, and should be periodically evaluated; Store the medicine in a cool, dry place, away from direct sunlight and out of the reach of children. Medicines should not be stored when not needed. Above is some information about Greatcet drug, this is a prescription drug and only used when indicated. Because of the risk of the drug harming the body, you should not self-medicate. Consult your doctor directly before taking to ensure safe use of the drug.
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