Uses of Vitalef 100

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1. What is Vitalef 100mg?

What is Vitalef 100mg? The main ingredient of Vitalef 100 is the active ingredient Sildenafil (as Sildenafil citrate) 100mg. Vitalef 100 is a product of Korea Prime Pharm. Co. Ltd. (Korea), circulating in Vietnam with the registration number VN-20542-17.
An erection is a phrase that describes a condition in which the penis is filled with blood. This process occurs when the blood vessels that carry blood to the penis increase blood supply and vice versa, the blood vessels responsible for bringing blood out of the penis reduce blood flow. Under normal conditions, sexual stimulation in men leads to increased production and release of nitrite oxide in the penis. This substance further activates the enzyme guanylate cyclase to produce cyclic Guanosin Monophosphate (GMPc) which is mainly responsible for penile erection by affecting the amount of blood entering and leaving the male genitalia. The active ingredient Sildenafil in Vitalef 100 has the effect of inhibiting the enzyme phosphodiesterase-5 (PDE5), which is an enzyme that destroys GMPc. Therefore, Vitalef 100 has the ability to inhibit the destruction of GMPc, allowing it to accumulate and stay longer in the body to increase blood stasis and prolong the erection process.

2. Indications and contraindications of Vitalef 100

Vitalef 100 product is mainly indicated in the treatment of erectile dysfunction. This condition occurs when the penis cannot or does not maintain an erection sufficient to satisfy sexual activity. Note Vitalef 100 only works when men are sexually aroused.
The use of Vitalef 100 is contraindicated in the following cases:
People with hypersensitivity to Sildenafil and any other ingredients in Vitalef 100; The patient is taking concomitant organic nitrates of any kind or substances of Nitric oxide; Patients with severe hepatic impairment, hypotension, stroke, cerebrovascular accident or recent myocardial infarction; Patients with hereditary degenerative retinal disorders (such as retinitis pigmentosa) should not use Vitalef 100 ; Vitalef 100 is contraindicated for use in women, children under 18 years of age and pregnant women.

3. Dosage of Vitalef 100

Vitalef 100 is taken orally, to be effective men need sexual stimulation.
Dosage of the drug Vitalef 100
The usual dose is 50mg (1⁄2 Vitalef 100 tablets) at about 1 hour before sex. Depending on the level of effectiveness and tolerability of the patient, the dose can be increased to 100mg (1 Vitalef 100 tablet) or reduced to 25mg (1⁄4 Vitalef 100 tablets). The maximum dose is 1 capsule of Vitalef 100 with the frequency of use only 1 time per day; Elderly: Initial dose is 25mg, then depending on the level of effectiveness and tolerance to increase to 50mg and 100mg; Dosage for patients with renal failure: If mild to moderate (creatinine clearance 30-80ml/min) can use the same dose as normal people. For patients with severe renal impairment (creatinine clearance less than 30ml/min), the initial dose of Sildenafil is 25mg, then titrated up to 50mg and 100mg; Hepatic Impairment: Due to reduced clearance of Sildenafil in patients with impaired hepatic function (eg, cirrhosis), the initial dose of Vitalef 100 is 1⁄4 oral tablets. It can then be increased to 50mg and 100mg depending on how effective and tolerable the user is. Dosage of Vitalef 100 is for reference only, patients should consult their doctor about the dosage to set the optimal treatment effect.

4. Side effects of the drug Vitalef 100

Common side effects of Vitalef 100 with a frequency of more than 1% include headache, sudden flushing, dizziness, gastrointestinal disturbances, nasal congestion, visual changes, blurred vision. In some fixed-dose studies, gastrointestinal disturbances and altered vision with Sildenafil were more likely to occur with the 100 mg dose. However, most Vitalef 100 side effects are mild to moderate in severity, with frequency and severity increasing with dose.
Some side effects of Vitalef 100 include:
Allergic reactions; Increased heart rate; Vomiting, dry mouth; Increased thirst, increased glucose, blood sodium, blood urea or caused reflex hypoglycaemia; Increased muscle tone, decreased reflexes; Stimulates the cough reflex; Dry eyes, glaucoma;

5. Vitalef 100 . Drug Interactions

Sildenafil is mainly metabolised via cytochrome P450 CYP3A4 and CYP2B9, so cytochrome inhibitors such as Cimetidine, Erythromycin, Ketoconazole, Itraconazole, Ritonavir, Saquinavir... can reduce the elimination and increase the concentration of Sildenafil in plasma. when used concurrently with Vitalef 100 . Co-administration of Vitalef 100 with cytochrome P450 CYP3A4 inducers such as Rifampicin results in a decrease in Sildenafil plasma concentrations. Antacids containing magnesium hydroxide, aluminum hydroxide do not affect the bioavailability of Sildenafil citrate, therefore can be combined with Vitalef 100. To avoid drug interactions, patients need to inform their doctors about the drugs, herbs, and supplements they are using so that the doctor can consider and adjust them accordingly.

6. Be careful when taking Vitalef 100

Care should be taken when prescribing Vitalef 100 to the following patients:
Patients with a history of myocardial infarction, stroke, arrhythmia within 6 months; Patients with a history of cardiovascular disease; Patients with low blood pressure or hypertension; The patient was diagnosed with retinitis. Vitalef 100 should be used with caution in people with genital deformities, anatomical abnormalities (eg, angularity, fibrosis, Peyronie's disease) or conditions that can lead to pain during penile erection. When the erectile dysfunction caused by Vitalef 100 lasts more than 4 hours, the patient must be intervened with appropriate medical measures. Vitalef 100 contains Sildenafil, a drug used to treat erectile dysfunction in adult men. Patients need to have sexual stimulation when using it to ensure the highest effectiveness.
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