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Grabulcure is manufactured and distributed by Gracure Pharmaceuticals Ltd - India. The main active ingredient in the drug is fluconazole 150mg. Fluconazole is the active ingredient indicated for the treatment of oropharyngeal candidiasis, vaginal and vulvar fungal infections, meningitis,...
1. What is Grabulcure?
What is Grabulcure? Grabulcure contains the active ingredient Fluconazole 150 mg. The drug is in the form of capsules, and is packaged in a large box of 10 small boxes. Each small box contains 1 blister x 1 tablet. The drug is effective in the definitive treatment of Candida infections in the mouth, throat, esophagus, vulva - vagina, meningitis, ... and many other cases. The active ingredient Fluconazole in Grabulcure has an antibacterial effect by altering the permeability of cell membranes. Fluconazole is used in patients who are intolerant of common antifungal agents, because Fluconazole can be taken orally, so it is relatively well tolerated by patients. The drug can be used favorably for patients who need to treat fungus for a long time.
2.Indications and contraindications to the drug Grabulcure
2.1 Indications Grabulcure is indicated for the treatment of people with candida infections in the mouth - throat, esophagus, vagina - vulva, in case the patient has other severe systemic fungal infections such as urinary tract infections, lungs, peritoneum. Grabulcure drug is effective in the treatment of people with meningitis caused by the fungus Blastomyces, Histoplasma, Coccidioides immitis, or infection with Cryptococcus neoformans. Grabulcure is also used to prevent Candida infections in bone marrow transplant recipients who are undergoing chemotherapy or radiation therapy. In addition, Grabulcure is also used to prevent serious fungal infections (such as Candida infections, Coccidioides immitis, Histoplasma, Cryptococcus) in HIV-infected patients.
2.2.Contraindications Contraindicated to use Grabulcure for patients with hypersensitivity to any of the ingredients in the drug.
3. Dosage and how to take Grabulcure
3.1. Dosage of Grabulcure For patients who are young children, the dose of Grabulcure is used to treat the following: 6 mg/kg per day. For patients who are ill for a long time can be used twice a day: 6 mg/kg each time. Care should be taken not to exceed 600 mg in a day. Dosage of Grabulcure for prophylaxis in children: 3 mg/kg daily for superficial fungal infections, and 6 mg/kg for systemic fungal infections per day for children. mg/kg. For adult patients, the dose of Grabulcure used to treat fungal infections in the mouth and throat is as follows: Once a day with a dose of 50mg, the treatment duration is from 7 to 14 days. For some cases, patients can use high doses up to 200 mg in 1 time for the first day, the following days reduce to 100 mg in 1 time for 1 day. Minimum duration of treatment is 2 weeks. Dosage of Grabulcure drug used to treat fungal infections in the esophagus for adults: The dose of the drug used is the same as the dose for oral and pharyngeal fungal infections. Duration of treatment is at least 3 weeks and 2 weeks after symptom resolution. For adults with systemic fungal infections, the dose of Grabulcure drug is used as follows: Patients use 400 mg in 1 time for the first day, the following days take 1 time per day with a dose of 200mg, treatment in for at least 4 weeks and 2 weeks after symptom resolution. For cases of fungal infections of the peritoneum and urinary tract in adults, the daily dose of Grabulcure is from 50 to 200 mg. Dosage of Grabulcure drug used to treat fungal infections of the vagina and vulva for adults: Use a single dose of 150mg To treat meningitis caused by Cryptococcus for adults, the dose of Grabulcure drug needed Dosage will be: 400 mg in 1 time for the first day, then daily dosage from 200 mg to 400 mg in 1 time. The minimum duration of treatment is from 10 to 12 weeks and after retesting negative results. Dosage of Grabulcure used in the prevention of Candida infections in bone marrow transplant recipients: 400 mg once daily. In cases where a potentially severe decrease in granulocytosis is likely to occur, it should be used prior to neutrophil count reduction and continued for approximately 7 days after the leukocyte count has increased. For adults with impaired renal function, the dose of Grabulcure is as follows: When the creatinine clearance is greater than 50 ml/min, the patient should use the usual dose. When the creatinine clearance is in the range of 11 to 50 ml/min, the patient should use 1⁄2 of the usual dose For patients on hemodialysis: Use Grabulcure with the usual dose 3.2. How to use Grabulcure drug effectively Patients can use the drug orally because the drug is made in the form of capsules. Use warm or cooled boiled water to take Grabulcure.
Grabulcure is used orally and is well tolerated, very suitable for use in patients with fungal infections requiring long-term treatment.
Missed dose: If a dose of Grabulcure is forgotten, the patient should take it as soon as he remembers, but if it is almost time for the next dose, the patient should skip the missed dose and use a new dose of Grabulcure as usual. .
Overdose: Overdose can cause serious complications, so if any unusual signs appear, the patient should stop using Grabulcure.
4. Side effects when using Grabulcure
During the use of Grabulcure 150mg, patients may experience some side effects such as headache, rash. Besides, there are some side effects that affect the digestive system such as: abdominal pain, hangover, diarrhea ....
When the patient feels abnormal symptoms and tends to turn bad. You should see a doctor as soon as possible for advice and treatment in the most timely and appropriate way.
5. Grabulcure drug interactions
Grabulcure drug interactions can occur during the treatment of the disease as follows:
Grabulcure will increase the concentration of Phenytoin in the blood plasma when used with Phenytoin. Grabulcure increases the half-life of fluconazole when used with a sulphonylurea. Grabulcure will decrease the half-life and absorption of Fluconazole when used with Rifampicin.
6. Notes when using Grabulcure
6.1. Notes and cautions For patients requiring hemodialysis, Grabulcure should be used after dialysis. People with seborrheic dermatitis should not be prescribed Grabulcure. Patients who treat diseases caused by Cryptococcosis should pay attention to the dosage of Grabulcure. For patients with liver and kidney dysfunction, caution should be exercised when using Grabulcure. 6.2. Note the use of Grabulcure drug on pregnant women and nursing mothers For pregnant women, it is necessary to weigh the benefits and risks when using Grabulcure. Newborn babies can have birth defects when their mothers use Grabulcure at a dose of 400-800mg/day during the first 3 months of pregnancy to treat diseases caused by the fungus Coccidioides immitis. Breastfeeding mothers should not use Grabulcure, because it can be excreted in breast milk and has concentrations comparable to those in the blood. 6.3. Grabulcure drug storage Users should store the drug in a place with relative humidity, cool, temperature not exceeding 30 degrees Celsius. Keep the medicine out of reach of children and pets in the house.
Grabulcure has the main active ingredient in it, fluconazole, 150mg. Fluconazole is the active ingredient indicated for the treatment of oropharyngeal candidiasis, vaginal yeast infections, and meningitis. When using the drug, the patient must strictly follow the instructions to achieve the maximum effect.
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