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Glogyl drug contains the active ingredient combination between Metronidazol and Spiramycin. The drug is indicated in the treatment of acute or chronic oral infections. Let's learn about the uses, dosage and notes when using Glogyl through the article below.
1. Uses of Glogyl
1.1. Uses of each ingredient The use of Glogyl is a combination of the effects of each ingredient, which is the antibiotic Metronidazol 125mg and the antibiotic Spiramycin 750000IU. Specifically as follows:
Sipramycin: An antibiotic belonging to the Macrolide group, acting through the mechanism of inhibiting the growth of bacterial cells by reversibly binding to the 50S subunit of the Ribosome, from which the drug prevents the bacterial protein synthesis; Metronidazol: An antibiotic belonging to the 5-Nitroimidazol derivative, acting through the mechanism of inhibiting bacterial protein synthesis, destroying the helix structure of DNA and inhibiting sensitive bacterial cells. 1.2. Indications for the drug Glogyl “What is Glogyl? This is a combination antibiotic between two active ingredients, Metronidazol and Spiramycin. Glogyl is indicated in the following cases:
Treatment of acute and chronic oral infections, recurrent oral infections (especially submandibular inflammation, parotid gland inflammation, gingivitis, tooth abscess, inflammation of the gums, inflammation of the gums, and inflammation of the gums. periodontitis , stomatitis); Prevention of oral infections after surgery.
2. Dosage of Glogyl
Glogyl medicine is taken orally, the dose of medicine used is prescribed by the treating doctor based on the patient's age and condition. All drug dosage information below is for reference only, patients absolutely do not arbitrarily use the drug without consulting a doctor. The recommended dose of Glogyl is as follows:
Children from 6 to 10 years old: Take 1 tablet of Glogyl x 2 times a day; Children from 10 to 15 years old: Take 1 tablet of Glogyl x 3 times/day each time; Adults: Take 4-6 tablets of Glogyl/day, divided into 2-3 oral doses. In severe cases, the dose can be increased to 8 tablets/day.
3. Side effects of the drug Glogyl
Glogyl can cause some unwanted effects as follows:
Undesirable effects related to Metronidazol:
Common: Gastrointestinal disorders such as metallic taste in the mouth, nausea; Uncommon: Diarrhea, constipation, vomiting. Undesirable effects related to Spiramycin:
Common: Vomiting, nausea, diarrhea, dyspepsia; Uncommon: Nosebleeds, fatigue, skin rash, acute colitis, sweating, urticaria; Rare: Anaphylactic reactions, superinfection due to long-term treatment with Spiramycin. In case of experiencing side effects, the patient should stop using Glogyl and immediately notify the treating doctor for timely treatment.
4. Note when using Glogyl
Contraindicated to use Glogyl in the following cases:
Women who are breastfeeding; Patients with hypersensitivity to Spiramycin, Metronidazol, Acetyl Spiramycin or to any of the ingredients of Glogyl. Precautions for use:
Caution should be exercised when using Glogyl in patients with liver dysfunction. Glogyl should not be used in alcoholic patients due to the risk of disulfiram-type reactions. Long-term treatment with Glogyl may lead to transient epileptic seizures, peripheral neuropathy, and transient leukopenia. Pregnancy: There are no studies demonstrating the harmful effects of Glogyl in pregnant women. However, the metronidazol component in the drug has the potential to cause cancer in some animals, so Glogyl should not be used in pregnant women. Lactation: The drug is excreted in breast milk and should not be used in lactating women.
5. Drug interactions
The drug Glogyl can cause some drug interactions as follows:
Concomitant use with Phenobarbital reduces the plasma concentration of Metronidazol, leading to a decrease in the effectiveness of the drug Glogyl; Drinking alcohol during treatment with Glogyl increases the risk of a disulfiram reaction; Concomitant use with Disulfiram increases the risk of acute psychosis, confusion; Fluorouracil, Lithium, Phenytoin, Warfarin, Cyclosporin: Glogyl drugs reduce metabolism, reduce elimination of the above drugs, leading to increased side effects of the drug; The drug Glogyl increases the side effects of Vecuronium; The drug Cimetidine increases the plasma concentration of the metronidazol component, thereby increasing the risk of neurotoxicity; Spiramycin in Glogyl reduces the effect of oral contraceptives; Spiramycin reduces plasma concentrations of Levodopa. Above are the uses of Glogyl medicine. To use the drug safely and to maximize the effectiveness of treatment, patients need to use it exactly as prescribed by the doctor.
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