Uses of Gaszac 300

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1. What is Gaszac 300?

Gaszac 300 medicine has the main active ingredient is Nizatidine with a content of 300mg and other excipients in a sufficient amount. This is a medicine for the treatment of diseases of the gastrointestinal tract, namely the treatment of stomach ulcers, gastroesophageal reflux disease, ...
Gaszac 300 is prepared in the form of hard capsules, suitable for use. by direct oral route. The box contains 3 blisters and each pack contains 10 pills.
1.1. Pharmacodynamics of the active ingredient Nizatidine The main active ingredient Nizatidine is an H2-histamine antagonist diuretic.
1.2. Pharmacokinetics of the active ingredient Nizatidine Absorption: The active substance Nizatidine is rapidly and completely absorbed. The active substance reaches high plasma concentrations 1 to 2 hours after oral administration. The oral bioavailability of the active ingredient Nizatidine is about 75-100%. Distribution: Active substance Nizatidine is bound to plasma proteins at an average of 50%. Metabolism: Active substance Nizatidine is metabolised by the liver, the drug crosses the cerebrospinal fluid, placenta and breast milk. Elimination ability: This active substance is eliminated by the kidneys over 60% as unchanged drug. 1.3. Effect of the active ingredient Nizatidine The main active ingredient Nizatidine has the effect of reducing the secretion of hydrochloric acid and gastric pepsin. Acid hydrochloride and gastric pepsin are considered as an attack factor, aggravating inflammation, peptic ulcer. Mechanism of action of the active ingredient Nizatidine: Because the drug has a similar formula to Histamine, the H2-histamine antagonist competes with histamine at the H2 receptor in the gastric parietal cells, preventing the secretion of gastric juice by other causes. causes increased secretion of histamine in the stomach. Active ingredients also have the effect of reducing both the amount and concentration of HCl in the gastric juice. Nizatidine has no effect on H1 receptors but only selectively affects H2 receptors in the stomach. Active ingredient Nizatidine has no effect on Cytocrom P450 in the liver.

2. What are the effects of Gaszac 300?

Kagawas 300 medicine has the main active ingredient Nizatidine, which belongs to the group of drugs that inhibit gastric acid secretion and antihistamine H2, selected in the treatment of:
Treatment of advanced gastric and duodenal ulcers. Treatment of gastroesophageal reflux disease, esophagitis. Treatment of symptoms of burning, heartburn, indigestion caused by excess gastric acid.

3. Usage and dosage of Gaszac 300

Dosage for advanced duodenal ulcer: The recommended adult dose is 300mg, taken once in the evening, or 150mg once, taken twice in 24 hours. Prophylactic or prophylactic dose (maintenance dose to prevent recurrence): The recommended adult dose is 150 mg orally once every 24 hours, taken in the evening. Dosage for treatment of progressive benign peptic ulcer: The recommended dose for adults is 300mg orally, once before bedtime, or divided into two times a day and 150mg each time. Before initiating therapy, the risk of malignant gastric ulcer should be carefully excluded. Dosage for Gastroesophageal Reflux Disease: The oral dose for adults for the treatment of mucosal abrasions, peptic ulcers, and heartburn is 150 mg each time, twice in a 24-hour period, or can be used up to 300 mg each time, 2 times in a 24-hour period. Based on pharmacokinetic data in subjects with renal impairment, the therapeutic dose should be reduced in elderly patients with creatinine clearance less than 50 mL/min. The clinical effectiveness of dose reduction in patients with renal failure has not been evaluated. For patients who have difficulty swallowing capsules whole, Gaszac 300 capsules can be opened and immediately mixed the ingredients in the tablet into liquid to drink. It should be noted: The above dosage is for reference only, patients need to take the drug according to the instructions and prescriptions of the doctor to increase the effectiveness of treatment, and at the same time limit the unwanted side effects. out.

4. Undesirable effects of the drug Gaszac 300

In the process of using Gaszac 300, you may experience some unwanted effects, specifically as follows:
Anemia, skin urticaria, liver cell damage. For the central nervous system: transient mental confusion (rare). For endocrine system: Active ingredient Nizatidine has no effect in antiandrogen. Impotence and decreased sex drive may also occur. Rare cases of gynecomastia in men. Hematologic system: Anemia was more common in patients using drugs containing the active ingredient nizatidine than in patients receiving placebo. Fatal thrombocytopenia was seen in a patient using a drug containing the active ingredient Nizatidine in combination with another Histamine H2 antagonist; This patient also had a history of thrombocytopenia while being treated with other drugs. There have also been rare cases of thrombocytopenic purpura after taking drugs containing the active ingredient Nizatidine, specifically Gaszac 300. Skin: Sweating and urticaria are common in people using medicines containing Nizatidine. A number of other undesirable effects such as skin redness and exfoliative dermatitis have also been reported. Hypersensitivity Reactions: Specific rare hypersensitivity reactions such as bronchospasm, laryngeal edema, skin redness, increased eosinophil counts have also been reported. Other Adverse Reactions: Increased uric acid/blood levels not due to gout or nephrolithiasis, eosinophilia, fever and nausea may have been associated with the use of drugs containing the drug. Nizatidine active ingredients, specifically Gaszac 300 were also recorded. In addition to the undesirable side effects mentioned above, if the patient encounters any other adverse effects, it is necessary to immediately notify the treating doctor to know in time to adjust and possibly change the drug in the following cases. necessary case.

5. Gaszac 300 . drug interactions

Interactions of Gaszac 300 may occur during use as follows:
Because Gaszac 300 causes inhibition of gastric acid secretion, gastric pH increases when using this drug. This reduces the absorption of some acidic drugs when used concurrently, specifically: Penicillin V, ketoconazole, itraconazole.... Because Antacid creates a protective film on the gastric mucosa - duodenum, it will reduce the absorption of the drug Gaszac 300 . Therefore, if you use the drug with Antacid, you need to take Gaszac 300 at least 2 hours before taking the Antacid. In order to avoid drug interactions, patients need to inform their doctor about the drugs, herbs, and health care products they are using so that the doctor can consider and prescribe appropriate drugs.

6. Some notes when using Gaszac 300

During the use of Gaszac 300, the following should be noted:
6.1. Contraindications of the drug Gaszac 300 Do not use Gaszac 300 for people who are sensitive to the main active ingredient Nizatidine or any other ingredient in the drug. If the user of Gaszac 300 has ever had a hypersensitivity reaction to any drug of the H2 antihistamine class, absolutely do not use this medicine. The reason is that there is a cross-sensitivity between compounds belonging to the group that antagonizes Histamine with H2 receptors, including the active ingredient Nizatidine, so the drug should not be used for people with a history of hypersensitivity to other substances that also antagonize the H2 receptor. Histamine with H2 receptors. 6.3. Notes on pregnancy and lactation For women during pregnancy: Use caution when using the drug for pregnant women. The reason is that the drug Gaszac 300 can be transported across the placenta into the fetal circulation and harm the fetus. Therefore, you need to carefully weigh the benefits and harms for both mother and fetus before deciding to prescribe this object. For women in lactation: Women in lactation should not use, because the drug is excreted in breast milk. Therefore, the risks and benefits must be weighed in order to choose whether to discontinue use of Gaszac 300 or discontinue breast-feeding to ensure safety for both the mother and the nursing infant. Do not arbitrarily use this drug until you have carefully read the instructions for use and instructions of the treating doctor to protect both mother and baby. In addition to treatment with Gaszac 300, people with peptic ulcer disease also need to avoid exposure to agents that can cause or worsen symptoms or cause recurrence, including: No smoke (including passive smoking), do not drink alcohol, reduce psychological stress, do not arbitrarily use antipyretic, analgesic, non-steroidal anti-inflammatory drugs or NSAIDs.
Above is all information about Gaszac 300, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Gaszac 300 to treat diseases at home, because there may be unwanted side effects on health.
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