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Vitamins B1, B6, B12 play an important role in many metabolic processes of the body. The deficiency of these vitamins causes many different diseases, so it is necessary to supplement with external products containing Fursultiamine (a derivative of Thiamin), Pyridoxine and Cyanocobalamin.
1. What is Fursultiamine?
Active ingredient Fursultiamine is a disulfide derivative of thiamin (also known as vitamin B1), often accompanied by other ingredients such as Pyridoxine HCL (vitamin B6) and Cyanocobalamin (vitamin B12)
Each film-coated tablet contains Fursultiamine 50mg, Pyridoxine HCL 250mg and Cyanocobalamin (vitamin B12) 0.25mg.
2. Pharmacological characteristics of the drug Fursultiamine
2.1. Pharmacodynamics Fursultiamine is a derivative of thiamin (or vitamin B1) with outstanding advantages over conventional thiamine hydrochloride as follows:
Higher affinity for tissues; Capable of rapid metabolism to the active form of thiamine, cocarboxylase; In terms of pharmacology, Fursultiamine also has analgesic effects, especially synergistic with other analgesics; Fursultiamine is also effective against paralytic ileus and neurogenic bladder disorders. The compound often accompanied by Fursultiamine is Pyridoxine HCL, which plays a very important role in the body's protein and lipid metabolism, in addition to stimulating the activity of damaged nerve cells. Pyridoxine has been shown to have a direct effect on the absorption of amino acids from the small intestine. In addition, increasing scientific evidence shows that vitamin B6 is closely related to the metabolic processes of the nervous system.
Cyanocobalamin or Vitamin B12 has the role of preventing and treating anemia, while supporting the maintenance of normal function of epithelial cells, nervous system and red blood cell production. In addition, Cyanocobalamin is essential for the synthesis of nucleoproteins and muscle fibers, for cell regeneration, or for maintaining the normal development of growing bodies. Because methylation (transmethylation) involves the conversion of homocysteine to methionine, cyanocobalamin acts as a hepatoprotective and lipophilic factor.
2.2. Pharmacokinetics Absorption:
Fursultiamine has good absorption from the gastrointestinal tract; Pyridoxine HCL is rapidly absorbed from the gastrointestinal tract after oral administration. It has been reported that absorption may be impaired if the patient has undergone gastric bypass surgery; Cyanocobalamin is mostly absorbed in the stomach by intrinsic factors present in the gastrointestinal tract. Once absorbed, Cyanocobalamin will bind to proteins especially transcobalamin, this combination leads to rapid absorption of cyanocobalamin into tissues. Distribution:
Fursultiamine has a high concentration in the blood and is long-acting; Pyridoxine HCL is mainly stored in the liver, a little in muscle and brain. Total body stores are about 16-27 mg and the active substance is not bound to plasma proteins; Cyanocobalamin is distributed in the liver, bone marrow, can cross the placenta and breast milk. Metabolism:
Fursultiamine is not degraded with aneurine, relatively low toxicity and rare side effects; Pyridoxine HCL in erythrocytes is converted to the active form pyridoxal phosphate. In the liver, pyridoxine is phosphorylated to pyridoxal phosphate and then to pyridoxine and pyridoxamine. Pyridoxal phosphate is completely bound to plasma proteins; Cyanocobalamin is converted to a coenzyme form in the liver and stored in various tissues. Elimination:
Fursultiamine : No elimination characteristics of this active substance have been reported; Pyridoxine HCL: Half-life from 15 - 20 days. In the liver, pyridoxine is oxidized to 4-pyridoxic acid and excreted in the urine. Pyridoxine also crosses the placenta and breast milk. If the daily requirement is exceeded, the drug is excreted unchanged in the urine; Cyanocobalamin is stored in the liver, excreted in the bile, while the absorbed part is excreted in the urine most of the first 8 hours.
3. What effect does Fursultiamine have?
Indications of Fursultiamine are mainly in the treatment of diseases caused by vitamin B1, B6, B12 deficiency such as neuralgia, polyneuritis, anemia...
Contraindications of Fursultiamine
People with history of hypersensitivity to blood components; Cases with malignant tumors.
4. Instructions for using Fursultiamine
Fursultiamine is indicated for use in adults with a dosage of 1 to 3 tablets per day or as directed by a doctor.
5. Fursultiamine side effects
Side effects of the drug Fursultiamine are relatively rare, some patients complain or have nausea, vomiting when taking the drug.
Some cases of vitamin B6 use at a dose of about 200mg / day and lasting for more than 2 months can cause severe peripheral neuropathy side effects, progressing from unsteady gait, frostbite to the hands and feet. and clumsy. However, this condition can be reversed when the drug is stopped, although there are still some sequelae. Vitamin B12 can cause some side effects such as acne-like skin reactions, hives, itching, redness of the skin.
Patients need to quickly inform the doctor about the unwanted effects encountered when using Fursultiamine.
6. Some notes when using Fursultiamine
Children should only use Fursultiamine as prescribed by a doctor and under adult supervision. Pregnant women should only use Fursultiamine exactly as prescribed by a doctor. Breastfeeding women are the same, only the doctor prescribed Fursultiamine. Fursultiamine does not affect the ability to drive and use machines. To date, there are no reports of overdose with Fursultiamine. If you forget to take a dose of Fursultiamine, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the next dose at the scheduled time, do not double the dose of Fursultiamine as directed.
Fursultiamine is mainly indicated in the treatment of diseases caused by vitamin B1, B6, B12 deficiency such as neuralgia, polyneuritis, anemia... To ensure effective use and To avoid unwanted side effects, users need to strictly follow the instructions of a doctor, professional pharmacist.
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