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With the main ingredient is Fluconazole, Foocgic drug helps to treat Candida and Cryptococcus infections. Refer to the article below to get more useful information about Foocgic.
1. Uses of the drug Foocgic
What is Foocgic? Fluconazole ingredient in Foocgic belongs to the group of Triazol, has antifungal effect. Fluconazole has an inhibitory effect on cytochrome P450 14-Alpha-Demethylase, so the synthesis of Ergosterol cannot take place. The drug is able to specifically inhibit the fungal cytochrome P450 system and has only weak affinity for mammalian P450 enzymes.
Foocgic is indicated in the following cases:
Treatment of candidiasis in the vulva - vagina. Candidiasis of the mouth - pharynx, esophagus, urinary tract, peritoneum and other serious systemic candidal infections such as candidaemia, pulmonary, disseminated candidiasis. Meningitis caused by Cryptococcus neoformans. Fungal diseases caused by Blastomyces, Coccidioides immititis and Histoplasma. In addition to its therapeutic effect, Foocgic is indicated in the prophylaxis of Candida infections in immunocompromised patients, cancer patients, or AIDS patients.
On the other hand, Foocgic is absolutely contraindicated in the following cases:
Patients who are using Terfenadine must not take the drug with a dose of 400mg or more. Breastfeeding women. Children under 12 months of age The patient is sensitive to any ingredient of the drug.
2. Usage and dosage of Foocgic
Foocgic is taken in capsule form which should be taken orally. Patients are advised to take whole tablets, do not crush or break them to avoid affecting the pharmaceutical properties of the drug.
Dosage of the drug will be adjusted depending on the purpose of treating the fungus that causes disease in humans. Below is a reference dose of Foocgic:
Dosage for children:
Prophylactic purposes for children are assigned a dose of 3mg/kg/day in superficial fungal infections and a dose of 6-12mg/ kg/day in systemic fungal infections.
The purpose of treatment for children is prescribed by the doctor at a dose of 6mg/kg/day. When the disease persists for a long time, up to 12mg/kg/24 hours can be used in 2 divided doses. Be careful not to take more than 600mg/day.
Dosage for adults:
Treatment of candida infections in the mouth - pharynx: Use a dose of 50mg / time / day, for a period of 7-14 days. Or higher dose: On the first day, take 200mg once, the following days take 100mg/time/day for at least 2 weeks. Treatment of Candida infections of the esophagus: Use the same dose as above for at least 3 weeks and a minimum of 2 weeks from the time the symptoms are gone. Treatment of candida infections in the vulva - vagina: Use a single dose of 150mg. Treatment of systemic candidiasis: 400mg once on the first day, 200mg once a day in the following days for at least 4 weeks and at least 2 more weeks after a negative CSF culture. Treatment of cryptococcal meningitis: 400mg once on the first day, 200-400mg in the following days. Duration of treatment is at least 10-12 weeks from the time of culture of cerebrospinal fluid depending on the negative result. For patients with renal failure: Adjust dose based on creatinine clearance: Note, this is a reference dose, patients should be examined by a specialist to be prescribed the most appropriate dose.
In case of missed dose, the patient should take Foocgic as soon as he remembers. You can skip the missed dose if it is almost time for your next dose. Avoid taking a double dose to make up for a missed dose. This can increase the side effects, affecting the patient's health.
It has been recorded that the patient overdosed on Foocgic and had symptoms such as: paranoia, hallucinations... To overcome this situation, the patient was prescribed symptomatic treatment, in combination with other drugs. supportive measures, gastric lavage and dialysis if necessary.
3. Foocgic side effects
Before prescribing the drug, the doctor has weighed the benefits and risks that Foocgic
brings. However, patients may still experience some side effects such as headache, dizziness, nausea, vomiting, abdominal pain, diarrhea.... Some rarer side effects have been recorded such as: anemia, leukopenia, neutropenia and thrombocytopenia, scaly skin, Stevens-Johnson syndrome, oligouria, hypotension, hypokalemia or anaphylaxis.
4. Foocgic drug interactions
Drug interactions occur that not only increase the side effects but also reduce the effectiveness of the drug. Foocgic can also appear this condition if the combination with drugs/drugs is not suitable. Some drugs/drugs such as:
Do not use Fluconazole (200mg/day) and Rifabutin (300mg/day) Concomitant use of Fluconazole and Rifampicin may affect the pharmacokinetics of both drugs. Concomitant use with Zidovudine, Fluconazole interferes with the metabolism and clearance of Zidovudine. Coumarin anticoagulants can increase prothrombin time Cyclosporin in combination with fluconazole can increase cyclosporin plasma concentrations, especially in kidney transplant recipients. Careful monitoring of cyclosporin levels is required and the dose should be adjusted accordingly. fit. Fluconazole can increase the plasma concentration of Astemizol causing dangerous cardiovascular events. Concomitant administration of fluconazole and cisapride may increase plasma concentrations of cisapride. Phenytoin in combination with fluconazole will increase the plasma concentration of phenytoin and increase the AUC of phenytoin leading to phenytoin toxicity, while the pharmacokinetics of fluconazole are not affected. Sulfonylureas antidiabetic drugs
5. Safe use of Foocgic drugs
Pregnant women need to consult a doctor before using Foocgic. Because of the fact, there have been cases of newborns with birth defects in many parts when mothers used high doses of fluconazole (400-800mg/day) in the first 3 months of pregnancy. Similar to pregnant women, breastfeeding women also need to consult a doctor if there is a need for medication. This is because fluconazole is likely to be excreted in milk at concentrations similar to those in plasma. One of the side effects of Foocgic is drowsiness, dizziness.. Therefore, the group of subjects who often operate machinery and drive should be cautious while taking the drug. For patients with liver failure, the dose should be adjusted according to the doctor's prescription. Each drug will have different storage regulations, so patients need to carefully read the instructions for storing Trajenta on the packaging, or ask the pharmacist.
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