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Fluanxol Depot belongs to the group of antipsychotic drugs indicated for the treatment of neuropsychiatric symptoms, psychotic manifestations due to alcoholism, withdrawal syndrome,... So who should Fluanxol Depot drug be used for and for whom? What is the dosage?
1. What is Fluanxol Depot?
Fluanxol Depot with the main ingredient is flupentixol - is an antipsychotic drug, a derivative of the thioxanthen group
The antipsychotic effect of Fluanxol Depot is due to antagonism at both dopamine D1 and D2 receptors (postsynaptic receptors in the brain). central nervous system), leading to inhibition of dopamine-mediated effects causing cognitive and behavioral disturbances. The drug reaches peak plasma concentrations 3 to 7 days after intramuscular injection and begins to work 24 to 72 hours after injection.
Fluanxol Depot is metabolized in the liver, the half-life of the drug is about 35 hours. The drug is excreted mainly in the faeces and a small amount is excreted in the urine. The drug crosses the placental barrier.
2. Indications of the drug Fluanxol Depot
Fluanxol Depot is indicated in the following cases
Patients with acute psychosis. Stable treated chronic psychotic disorders continue to be maintained. Psychosis with behavioral disturbances in alcoholic patients. Alcohol withdrawal syndrome in patients undergoing alcohol withdrawal. Excessive psychomotor arousal states.
3. Contraindications of Fluanxol Depot
Cases in which Fluanxol Depot should not be used.
Allergy to flupentixol or any other ingredient of the drug. Patients with urinary disorders, prostate enlargement (risk of urine retention). Angle closure glaucoma. Patients with barbituric poisoning. Patient is comatose, circulatory failure. Patients who are easily excitable should not take the drug. Note when using Fluanxol Depot
Fluanxol Depot can cause neuroleptic malignant syndrome (muscle stiffness, autonomic nervous system dysfunction, hyperthermia, impaired consciousness). It should be used with caution, especially in subjects with mental retardation, drug abuse, and alcohol abuse. It is necessary to monitor hematological parameters regularly when taking the drug due to the risk of thrombocytopenia, hematological disorders of the drug. It is necessary to monitor and adjust insulin dose in diabetic patients taking Fluanxol Depot. Abrupt discontinuation of the drug may cause withdrawal syndrome (nausea, vomiting, sweating, insomnia,...). The drug increases the risk of malignant arrhythmias. Fluanxol Depot and other antipsychotics have a risk of venous thrombosis. Patients and caregivers should be warned about unusual behavioral changes when taking medication, suicidal thoughts. Side effects such as confusion, low blood pressure, and changes in body temperature are common in the elderly. Therefore, caution should be exercised when using the drug in this subject. The drug crosses the placenta, so its use should be limited to pregnant women, because there is not enough evidence to ensure the safety of the drug. The drug is excreted in breast milk, so when taking the drug, mothers should stop breastfeeding. The drug may cause drowsiness and blurred vision. Therefore, drivers, machine operators, people who do jobs that require concentration should not be used.
4. Drug interactions of Fluanxol Depot
Fluanxol Depot enhances the effect of anticoagulants, anesthetics, barbiturates and other CNS depressants.
Antipsychotics, lithium, sibutramine increase the risk of neurotoxicity when used with Fluanxol Depot. Drugs that increase the effect of atropine or other drugs with anticholinergic properties. Fluanxol Depot potentiates the cardioinhibitory effects of quinidine, increases the absorption of steroids and digoxin, and enhances the vasodilator effect of antihypertensive agents.
Increased risk of arrhythmia when used with diuretics. Fluanxol Depot reduces the effects of levodopa, adrenergic and anticonvulsant drugs.
Fluanxol Depot inhibits the metabolism of tricyclic antidepressants, impairing the glycemic control of insulin and oral drugs in patients with diabetes.
5. Dosage and how to use Fluanxol Depot
How to use
The drug is prepared in the form of a solution for injection. Used for intramuscular injection. Dosage
Patients who have never been treated with long-acting antipsychotics: Initial dose of 5 - 20 mg/ 2 weeks; Closely monitor response to treatment for 5 - 10 days. In elderly, frail, debilitated patients or patients with a predisposition to extrapyramidal reactions, an initial dose of 5 mg every 2 weeks is recommended. Patients with prior exposure and well tolerated long-acting antipsychotics: 20 to 40 mg intramuscularly every 2 weeks. Dosage of Fluanxol Depot is individualized, so it should be maintained at the lowest effective dose.
6. Fluanxol Depot side effects
Possible side effects when using Fluanxol Depot
Common
Weight gain, increased appetite. Sleep disorders . Anxiety, anxiety, depression, agitation. Decreased libido in both men and women. Consciousness disorder. Dizziness, dizziness, headache. Muscular dystonia, myalgia, tremor. Increase heart rate. Dry mouth or increased salivation. Indigestion, diarrhea, nausea, vomiting. Feeling tired, weak body. Uncommon
Skin rash, increased photosensitivity reaction. Erectile dysfunction, low sperm count. Pain and itching at the injection site. Liver dysfunction. Reduced eyesight. Thus, Fluanxol Depot is a psychotropic drug indicated for psychotic disorders, disorders of consciousness. Drugs must be prescribed and monitored by a neuropsychologist, without abuse, arbitrarily changing dosage or stopping abruptly.
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