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Febalin 75mg or Pregabalin is an anticonvulsant drug, with analgesic effect, quickly reducing neuralgia, epilepsy, generalized anxiety disorder in adults.1. What is Febalin?
What is Febalin? Febalin 75mg has the ingredient Pregabalin 75mg, structurally similar to the CNS depressant GABA. However, not directly binding to GABA receptors, or to benzodiazepine receptors, did not increase GABA responses in cultured neurons. Besides, it also did not change the concentration of GABA in the rat brain, and did not affect GABA absorption or degradation. Febalin 75mg reduces the release of calcium-dependent neurotransmitters such as glutamate, norepinephrine, calcitonin gene-regulatory peptide, and substance P, possibly through regulation of calcium channel function.
Febalin 75mg is rapidly absorbed from the gastrointestinal tract and maximum concentration is reached after oral administration is 1.5 hours. Oral bioavailability is about 90%. Food slows the rate but not the extent of absorption.
Approximately 98% is excreted unchanged by the kidneys. The mean half-life is 6.3 hours.
2. Indications and contraindications of Febalin 75mg
2.1. Indications Febalin 75mg is indicated in the following cases:
In combination with anticonvulsants to treat partial seizures in adults. Generalized anxiety disorder. Neuropathic pain: Diabetic peripheral neuritis, postherpetic neuralgia. Fibromyalgia muscle pain. Treatment of neuropathic pain of central and peripheral origin. 2.2. Contraindications of Febalin 75mg Febalin 75mg is contraindicated in patients with hypersensitivity to any ingredient of the drug.
3. Precautions when using Febalin 75mg
Anticonvulsants, including Febalin 75mg, often increase the risk of suicidal thoughts/behaviour. Therefore, patients should be closely monitored for signs of depression, suicidal tendencies, and unusual behavioral changes during treatment. Febalin 75mg should be used with caution because it may cause peripheral edema. Febalin 75mg causes dose- and duration-related weight gain. However, weight gain was not associated with body mass index (BMI) before treatment, gender, or age, and was also not attributable to edema. For patients with pre-existing heart disease, the drug must be used with caution, as it may increase the risk of heart failure. Febalin 75mg may increase creatine phosphokinase (CPK) and may cause paroxysmal myoglobinuria (a type of muscle disease). The dose of Febalin 75 mg should be gradually discontinued and reduced for at least 1 week prior to discontinuation to avoid the increase in seizure frequency seen with anticonvulsants in general. Caution should be exercised in patients with a history of drug addiction. Watch for signs of drug abuse (such as tolerance, tendency to increase dose, or drug-seeking behavior). There are no adequate and well-controlled studies in pregnant and lactating women and should be used with caution. Febalin 75mg may cause dizziness and drowsiness and may therefore affect the ability to drive or use machines. Patients with renal failure, diabetes mellitus, cardiovascular disease, factors that can promote the development of encephalopathy in elderly patients. Children <12 years and adolescents (12-17 years): Safety and efficacy have not been established.
Dosage and how to take Febalin 75mg
4.1. Dosage Adults
Adjuvant treatment of partial seizures: Initial dose is 150 mg/day, then gradually increased every week according to response, to 300 mg/day and then 600 mg/day.
Generalized Anxiety Disorder: Initial dose of 150 mg daily, may be increased gradually every week with increments of 150 mg to a maximum dose of 600 mg daily.
Pain due to neuritis, pain after Herpes:
Recommended dose: 150 - 300 mg/day, divided into 2 - 3 times. Initial dose: 150 mg/day, may be increased to 300 mg/day within 1 week, depending on efficacy and tolerability. If there is still no improvement after 2-4 weeks of treatment with 300mg/day, the dose can be increased to 600mg/day in 2-3 divided doses. Doses in excess of 300 mg/day are only for those who still have pain and can tolerate 300 mg/day. Nerve pain due to diabetes:
Initial dose 150mg/day, divided into 3 times; The dose may be increased over 1 week to a maximum recommended dose of 300 mg/day in 3 divided doses. Increasing the dose does not add to the benefit, but many side effects occur. Fibromyalgia:
Initial dose 150mg/day, increased after 1 week depending on response, to 300mg/day then 450mg/day if deemed necessary. Children: The safety and efficacy of Febalin 75mg have not been established in children under 12 years of age and adolescents (12-17 years of age).
Other subjects:
For patients with renal failure: Need to adjust dose according to glomerular filtration rate, specifically as follows: Glomerular filtration rate from 30 to less than 60 ml/min: Starting at 75mg/day, maximum 300mg/ day; Divide 2-3 times. Glomerular filtration rate from 15 to less than 30 ml/min: Start 25 - 50 mg/day, maximum 150mg/day; Divide by 2 or use only 1 time. Glomerular filtration rate less than 15 ml/min: Starting at 25mg/day, maximum 75mg/day, used as a single time. Hemodialysis patients: An additional dose of 25-100 mg Febalin should be received immediately after each 4-hour dialysis session. 4.2. How to use Febalin 75mg is taken orally, divided 2-3 times per day, patients can take with or without food.
5. Side effects of Febalin 75mg
During the use of Febalin 75mg, patients may experience some side effects as follows:
Common effects
Peripheral edema. Dizzy . Drowsiness, loss of luck Headache. Weight gain. Dry mouth. Muscle tremor. Blurred vision, double vision. Uncommon effects:
Chest pain. Neuritis. Unusual thoughts, fatigue, confusion, euphoria. anxiety, depression Language disorders, attention disorders. Increased muscle tone, lethargy, stupor or agitation. Facial edema, bruising, hypoglycemia, Constipation, appetite, flatulence, vomiting, abdominal pain, gastroenteritis, Polyuria and urinary incontinence, loss of pleasure, decreased sex drive. Thrombocytopenia, myalgia, myasthenia gravis. Rare effects
Anaphylaxis . Acute renal failure, albuminuria. Erectile dysfunction. Abnormal gait, feeling drunk, fatigue, peripheral edema, edema. Weight gain. Smoking withdrawal syndrome. Febalin 75mg or Pregabalin is an anticonvulsant drug, effective for pain relief, fast relief of neuralgia, epilepsy, generalized anxiety disorder in adults. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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