Uses of Euroxil 500

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1. What is Euroxil 500?

Euroxil 500 contains the active ingredient cefadroxil 500mg belongs to the group of first generation cephalosporin antibiotics.
Cefadroxil is an oral cephalosporin that works by inhibiting the synthesis of the bacterial wall of dividing cells. polarity by binding penicillin to one or more proteins. The result is the formation of a defective cell wall that is osmotically unstable and lysis of bacterial cells.
Cefadroxil may be active against organisms that produce certain types of beta-lactamases, for example TEM-1 in low to moderate amounts.
Cefadroxil is not expected to be active against bacteria whose penicillin-binding proteins have decreased affinity for beta-lactams. Resistance can also be mediated by bacterial impermeability or bacterial drug delivery systems.

2. Indications to use Euroxil 500

Drug Euroxil 500 is indicated in the following cases:
Strep throat, tonsillitis. Bacterial pneumonia, bronchopneumonia. Uncomplicated urinary tract infections: cystitis, pyelonephritis. Skin and soft tissue infections: boils, abscesses, pyoderma, lymphadenitis, mastitis, erysipelas.

3. Dosage - how to take Euroxil 500

How to use: Drug Euroxil 500 is used orally, to reduce the side effects on the gastrointestinal tract, the patient should take the drug with food.
Dosage:
Dosage depends on the susceptibility of the disease, the severity of the disease and the clinical condition of the patient (liver, kidney function).
Adults and adolescents (>40kg) with normal renal function:
Tonsillitis, streptococcal pharyngitis: dose may be 1g/day for at least 10 days. Bacterial pneumonia, bronchitis, urinary tract infections, skin and soft tissue infections: 1g x 2 times/day. Children (<40kg) with normal renal function:
Tonsillitis, strep throat: 30 mg/kg/day x 1 time/day for at least 10 days. Bacterial pneumonia, bronchitis, urinary tract infections, skin and soft tissue infections: 30-50mg divided 2 times daily. Euroxil 500mg capsules are not recommended for infants and children under 6 years of age. For children with body weight <40 kg, oral liquid form can be used. Children (<40 kg) with renal impairment:
Euroxil is not indicated in children with renal failure and in children requiring hemodialysis.
Patients on hemodialysis: An additional dose of 500 mg - 1000 mg is given at the end of hemodialysis.
Hepatic impairment: No dose adjustment is required.
Precautions for overdose:
There have been no clinical reports of overdose with Euroxil 500. However, from experience with other cephalosporins, the following symptoms may occur: nausea, hallucinations, increased reflexes, extrapyramidal symptoms, blurred consciousness, or even coma and impaired renal function. First aid after ingestion of toxic dose: induce vomiting immediately or gastric lavage, hemodialysis if necessary. Monitor and, if necessary, correct water and electrolyte balance, monitor renal function.

4. Contraindications of Euroxil 500

Contraindicated to use Euroxil 500 drug in the following cases:
Patients with hypersensitivity to any component of the drug Allergy to penicillins or other beta-lactam drugs.

5. Side effects of Euroxil 500

During use, patients may experience some of the following side effects:
Common: nausea, vomiting, diarrhea, dyspepsia, abdominal pain, glossitis, itching, urticaria. Uncommon: vaginal thrush, thrush. Rare: eosinophilia, leukopenia, neutropenia, thrombocytopenia, agranulocytosis, mild elevations in serum transaminases (AST, ALT) and alkaline phosphatase, angioedema, arthralgia, inflammation interstitial kidney, headache, trouble sleeping, dizziness, palpitations, Steven-Johnson syndrome, ...

6. Euroxil 500 . drug interactions

Euroxil should not be combined with bacteriostatic antibiotics (eg, tetracycline, erythromycin, sulphonamides, chloramphenicol) because of possible antagonistic effects. Treatment with cefadroxil in combination with aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics should be avoided, because the combination increases the nephrotoxic effect. To avoid bleeding complications, it is necessary to regularly check the coagulation parameters during the concomitant use of anticoagulants or platelet aggregation inhibitors for a long time to avoid bleeding complications. The bioavailability of Euroxil is reduced by binding to cholestyramine. Concomitant administration of Euroxil with probenecid reduces renal elimination of cefadroxil. Therefore, plasma concentrations of Euroxil may be increased.

7. Special warnings and precautions

Cefadroxil does not cross the cerebrospinal fluid, so Euroxil is not indicated in patients with meningitis. Particular caution should be exercised in patients with a history of severe allergies or asthma. In patients with a history of non-serious hypersensitivity to penicillins or other non-cephalosporin beta-lactam agents, special caution should be exercised when administering Euroxil because of the risk of cross-allergies (incidence 5-10%). Euroxil should be used with caution in patients with a history of gastrointestinal disorders, especially colitis. Treatment must be discontinued immediately if allergic reactions (urticaria, exanthema, pruritus, hypotension and increased heart rate, respiratory disturbances, collapse, etc.) (sympathomimetic drugs, corticosteroids and/or antihistamines). With prolonged use, patients should regularly check the blood count, check liver and kidney function regularly. Superficial fungal infections (eg candidiasis) may occur during prolonged treatment with Euroxil. Euroxil 500 contains the active ingredient cefadroxil 500mg of the first generation cephalosporin antibiotic group. The drug is used to treat a number of infectious diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug according to the prescription or consult a doctor, professional pharmacist.
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