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Esoragim 40 belongs to the group of gastrointestinal drugs, the main ingredient is Esomeprazole. The drug is used to treat severe gastro-oesophageal reflux, peptic ulcer disease, acid-producing disease, combined with antibiotics in killing HP bacteria.
1. What effect does Esoragim 40 have?
In children 12 years of age and older, Esoragim 40 is used in the treatment of gastroesophageal reflux disease with esophagitis.
In adults, Esoragim 40mg drug is used to treat peptic ulcers, severe gastro-oesophageal reflux disease (with complications from reflux esophagitis), prevention of gastric and duodenal ulcers. colon due to the use of non-steroidal anti-inflammatory drugs, killing HP bacteria when combined with antibiotics, diseases that cause increased acid secretion (including Zollinger-Ellison syndrome).
2. Dosage and how to use Esoragim 40
Esoragim 40 to be taken at least 1 hour before a meal, swallowed whole with water, do not chew or crush.
For children from 12 years of age and older used to treat gastroesophageal reflux disease with esophagitis with a dose of 1 tablet / time, 1 time / day for 4 consecutive weeks, can be treated for an additional 4 weeks if still not yet cured.
Dosage for adults is classified according to the disease type as follows:
Severe gastroesophageal reflux disease with esophagitis: 1 tablet/time, 1 time/day, for 4 consecutive weeks, can be treated 4-8 weeks if still not cured. In case of very severe disease, the dose can be increased to 1 tablet/time, 2 times/day. Treatment of peptic ulcers caused by HP bacteria: The combined dose of Amoxicillin and Clarithromycin includes Esoragim 40 1 tablet/time, 1 time/day, for 10 days; Amoxicillin 1g/time, 2 times/day; Clarithromycin 500mg / time, 2 times / day for 10 days. Prophylaxis of gastric and duodenal ulcers caused by the use of NSAIDs at a dose of 1 tablet/time, 1 time/day. Treatment of Zollinger-Ellison syndrome initial dose of 1 tablet/time, 2 times/day, then adjusted depending on the degree of gastric hypersecretion, mostly controlled at a dose of 80-160mg/day, with doses above 80mg/day should be divided into 2 oral doses. Patients with severe hepatic impairment should not exceed 20 mg/day; mild to moderate hepatic impairment does not require dose reduction. Patients with renal impairment and the elderly do not need to reduce the dose from the standard dose.
3. Contraindications of Esoragim 40mg
Esoragim 40mg is contraindicated in the following cases:
Children under 12 years old. Hypersensitivity to Esomeprazole or any of its ingredients. Do not use concurrently with Nelfinavir, Atazanavir.
4. Be careful when using Esoragim 40mg
Some things to note in the process of taking Esoragim 40mg include:
The drug can reduce symptoms of vomiting blood, difficulty swallowing, black stools, and other warning symptoms of cancer. Thereby, delaying the diagnosis of gastrointestinal cancer. With long-term treatment (over 1 year), careful monitoring is required because long-term treatment increases the risk of complications such as atrophic gastritis, gastrointestinal infections, osteoporosis, and hypomagnesaemia. The risk of interstitial nephritis can occur at any point during treatment and is usually due to an idiopathic hypersensitivity reaction. Decreased absorption of vitamin B12 due to decreased or deficient gastric acid, this should be considered during long-term treatment. Use with caution in pregnancy and lactation as there is not much clinical experience in these cases.
5. Side effects of Esoragim 40mg
During use, Esoragim 40mg may cause some side effects including:
Common (ADR > 1/100):
Systemic symptoms include headache, dizziness, skin rash. Gastrointestinal symptoms include nausea, vomiting, abdominal pain, diarrhea, constipation, flatulence, and dry mouth. Uncommon (1/1000 < ADR < 1/100):
Systemic symptoms include fatigue, insomnia, somnolence, rash, pruritus. Eyes: visual disturbances. Rare (ADR < 1/1000):
Systemic symptoms include photosensitivity, peripheral edema, fever, sweating, bronchospasm, urticaria, angioedema, anaphylaxis. The central nervous system includes agitation, anxiety, confusion, and hallucinations. Hematology includes leukopenia, thrombocytopenia, and agranulocytosis. Liver includes increased liver enzymes, jaundice, hepatitis, liver failure. The digestive system includes taste disturbances. Musculoskeletal system includes arthralgia, myalgia. The urinary system includes interstitial nephritis. Skin includes dermatitis, bullous rash, stevens-johnson syndrome, toxic epidermal necrolysis.
6. Drug interactions
Unexpected interactions may occur if Esoragim 40mg is used concurrently with the following drugs:
Concomitant use with Atazanavir, Nelfinavir, Clopidogrel may reduce the effect of these drugs. Concomitant use of Warfarin and other Coumarin derivatives may cause an increase in INR leading to abnormal bleeding and death, therefore, INR should be closely monitored during treatment. proteases can lead to changes in their uptake. Concomitant administration of Tacrolimus may increase its serum concentrations. Therefore, if used, during treatment, it is necessary to closely monitor tacrolimus levels and renal function (creatinine clearance) to adjust the dose accordingly. May increase the concentration of Methotrexate should consider temporarily stopping Esoragim 40. Concomitant use with Ketoconazole, Itraconazole, Erlotinib, Digoxin, .. changes the absorption of these drugs. Concomitant use with drugs metabolised by CYP2C19 such as Diazepam, Citalopram, Imipramine, Clomipramine, Phenytoin may increase the concentration of esoragim 40. Concomitant use with Voriconazole can cause a 2-fold increase in the concentration of Esoragim 40, caution should be taken when use high doses. Concomitant use with Cilostazol may increase the concentration of Cilostazol and its metabolites. The article has provided information about the uses, doses and precautions when using Esoragim 40mg. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Esoragim 40mg exactly as directed by your doctor.
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