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Epegis 50mg drug has the main ingredient Eperison 50mg, the drug is commonly used in the treatment of symptoms of muscle hypertonia and spastic paralysis in neurological, musculoskeletal diseases. Knowing the necessary information about the composition, uses, and dosage of Epegis 50mg medicine will help patients and their families improve the effectiveness of treatment, and at the same time prevent possible side effects.
1. What is Epegis 50mg?
Epegis 50mg drug is prepared in the form of film-coated tablets, with the main ingredients including:
Active ingredients: Eperisone (in the form of Eperison hydrochloride) content of 50 mg. Excipients: Just enough for 1 tablet of 50 mg. Mechanism of action Eperison hydrochloride has the main mechanism of action is to relax skeletal muscles, increase blood flow, create ease in voluntary movements, reduce pain and inhibit pain reflexes.
Mechanism of skeletal muscle relaxation:
Eperison hydrochloride reduces posterior membrane potentials in single and polysynaptic, thereby reducing bone marrow reflex. Eperison hydrochloride inhibits midbrain cross-sectional lossy spasticity and ischemic cerebral spasticity. Eperison hydrochloride inhibits the activity of afferent nerve fibers from the muscle spindle, thereby reducing the sensitivity of the muscle spindle. Mechanism of increased blood flow:
Eperison hydrochloride antagonizes calcium ions on vascular smooth muscle and destroys muscle sympathetics causing vasodilation. Vasodilation helps increase blood volume to the arteries and skin and muscle tissues. Mechanism of pain relief:
Eperison hydrochloride inhibits pain reflexes and neutralizes nerve mediators involved in pain transmission in the spinal cord.
2. What are the effects of Epegis 50mg?
Epegis 50mg is indicated for the treatment of:
Increased muscle tone seen in:
Neck pain, lumbar spine. Cervical vertebrae syndrome. Inflammation around the shoulder and lumbar joints. Spastic paralysis occurs in:
Cerebrovascular accident . Degeneration of cervical or lumbar vertebrae. Sequelae after spinal cord or brain injury. Postoperative sequelae in the spinal cord or skull. Bone marrow degeneration. Pulmonary vascular disease. Amyotrophic lateral sclerosis. Cerebral palsy .
3. Contraindications of Epegis 50mg
Contraindications of Epegis 50mg drug in the following cases:
Hypersensitivity to any ingredient of Epegis 50mg drug. History of allergy to other drugs containing the active ingredient Eperison hydrochloride.
4. Dosage and how to use Epegis 50mg
Epegis 50mg drug is made in the form of tablets, so the drug is taken orally. Dosage for reference is as follows:
Adults
Dose: Take 1 tablet (50mg)/time x 3 times/day. Consider dose adjustment according to age and medical condition. Children : Not recommended for use.
6. Side effects encountered when using Epegis 50mg
Treatment with Epegis 50mg drug with high dose or long term, can cause the following side effects:
Anaphylactic reaction or anaphylactic shock. Allergic hypersensitivity manifests as skin rash, erythema, urticaria, pruritus, angioedema. Systemic symptoms such as fatigue, dizziness, decreased muscle tone, muscle weakness. Neurological symptoms such as headache, insomnia, dizziness, vertigo, numbness in the limbs, tremor in the extremities. Decreased liver and kidney function. Digestive disturbances such as loss of appetite, dry mouth, stomatitis, nausea, vomiting, abdominal pain, flatulence, diarrhea or constipation. Urinary disorders such as anuria, urinary incontinence, urinary retention in the bladder. Anemia. Patients should stop taking the drug as soon as they detect the above symptoms after using Epegis 50mg or promptly notify their doctor, pharmacist and immediately go to the nearest medical facility for supportive treatment.
6. Note the use of Epegis 50mg
Notes on using Epegis 50mg in subjects
Be careful when using Epegis 50mg in people with severe liver and kidney dysfunction. Regular monitoring with evaluation tests is required when deciding to use Epegis 50mg in these subjects. Epegis 50mg contains the excipient is Lactose, so it should not be used in patients with galactose intolerance, hereditary glucose-galactose malabsorption or Lapp lactase deficiency. Pregnancy: There are limited data on the harmful effects of Eperison hydrochloride on the fetus. Therefore, only use Epegis 50mg when its benefits outweigh the harms. Lactation: There are no data to confirm whether the active ingredient Eperison hydrochloride contained in Epegis 50mg can be excreted in human milk. Therefore, the use of Epegis 50mg is contraindicated in this population, if necessary, discontinue breastfeeding. Drivers or machine operators may experience side effects such as dizziness, headache, and drowsiness after using Epegis 50mg. Avoid using drugs before and during work.
7. Epegis 50mg . drug interactions
Co-administration of Epegis 50mg with Methocarbamol may cause disturbances in visual accommodation. To avoid drug interactions, patients need to inform their doctors about the drugs, herbs and supplements they have been using.
Above is an overview of ingredients, uses, doses and notes when using Epegis 50mg. In order to get the best treatment results, patients should carefully read the instructions for use on the packaging of Epegis 50mg product, and follow the instructions of the treating doctor.
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