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Enafran 5 drug with the main active ingredient is Enalapril 5mg, usually prescribed by doctors for patients with high blood pressure or some cardiovascular diseases. To better understand what Enafran is, its uses, usage and dosage, the following article will help you get the answer.
1. Uses of the drug Enafran 5
In normal people, the maintenance of blood pressure at a stable level is due to many factors involved in regulation, one of which is the Renin - Angiotensin - Aldosteron system (RAA system for short). Renin factor is an enzyme secreted by the kidneys that acts as a catalyst for the conversion of angiotensinogen to angiotensin I. Inactive angiotensin I is converted to angiotensin II in the presence of the Angiotensin-converting enzyme. abbreviated as ACE or also known as “fermenting enzyme”). Angiotensin II is known to be a vasoconstrictor, besides it increases the activity of the sympathetic system leading to an increase in the release of aldosterone and vasopressin, resulting in increased blood pressure, increased heart rate, and increased circulation. The main ingredient in Enafran 5 is enalapril, which is an active ingredient that inhibits the activity of ACE inhibitors, reducing the formation of angiotensin II, resulting in a reduction in symptoms related to blood pressure and circulation. caused by a disorder of the RAA system.
From such a mechanism of action, doctors usually prescribe the use of Enafran 5 in the following cases:
Patients with hypertension; Patients with diseases such as heart failure, post-myocardial infarction, kidney disease caused by diabetes;
2. Dosage and how to use Enafran 5
Dosage of Enafran 5 is prescribed by the doctor for each case depending on the condition of each specific patient, the dosage for some indications is recommended as follows:
For patients with unspecified hypertension determine the cause: Start with a dose of 2.5 - 5 mg/day, maintain treatment with a dose of 10 - 20 mg/day, use once a day, do not use more than 40mg/day. During treatment, the doctor will base on the blood pressure readings to adjust the dose accordingly. For patients with heart failure: Doctors often use Enafran 5 in combination with diuretics, in the first 3 days of treatment usually 2.5 mg / day, in the next 4 days increase to 2.5 mg x 2 times /day, then gradually increased to a maintenance dose of 20 mg/day. When using the drug in patients with underlying medical conditions of renal failure, the dose is determined on the basis of creatinine clearance. Patients can use Enafran 5 before or after meals because food does not affect the absorption and effects of the drug.
3. Notes when using Enafran 5
Some patients using Enafran 5 encountered undesirable effects such as: excessive lowering of blood pressure, nausea, vomiting, taste disturbances, dizziness, fatigue, dry cough...In which, cough Anhydrous is considered the most common and typical undesirable symptom of Enafran 5 .
Caution when using Enafran 5 with vasodilators, oral contraceptives, bronchodilators, hyperkalemia drugs, non-steroid anti-inflammatory drugs because of the interaction. You should inform your doctor about the drugs you are taking before receiving treatment with Enafran 5 for timely advice and intervention.
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