Uses of Elitan 10mg

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1. What is Elitan?

What is Elitan drug? Elitan 10mg is used to prevent and treat vomiting and nausea in patients after surgery or radiation therapy. The main ingredient of the drug is metoclopramide hydrochloride anhydrous with a strength of 10mg.
Pharmacodynamics: Increases gastrointestinal motility. The component metoclopramide is a neuroleptic drug that has an antagonistic effect on dopamine, preventing symptoms of nausea due to inhibition of dopaminergic receptors.
Pharmacokinetics
Absorption: In case of oral administration, it is rapidly absorbed from the gastrointestinal tract about 50%. Metabolism: Metoclopramide is poorly metabolised. Distribution: Metoclopramide is widely distributed to tissues. The volume of distribution to the whole body is about 2.2 to 3.4 l/kg. The drug is poorly bound to plasma proteins and can be passed through the placenta and breast milk. Excretion: Metoclopramide is mainly eliminated in the urine as a free or sulfonyl-conjugated form. The elimination half-life is 5-6 hours and is increased in patients with hepatic and renal impairment. Dosage form: Solution for injection
Packing form: Box of 2 blisters x 5 ampoules of 2ml

2. Indications and contraindications for Elitan 10mg

2.1. Indications Depending on different subjects, Elitan 10mg is indicated in cases, specifically
Adult subjects:
The drug helps prevent vomiting and nausea after surgery. For cancer patients, it is used to prevent vomiting and nausea after radiation therapy. In addition, the drug helps to treat symptoms of vomiting and nausea, including vomiting and nausea caused by acute migraine.
Subjects are children from 1-18 years old: Elitan 10mg is a second-choice drug for the prevention of vomiting and nausea caused by chemotherapy as well as the treatment of this condition after surgery.
2.2. Contraindications Elitan 10mg is contraindicated in the following cases:
Pregnant women in the last 3 months and lactating mothers. Patients who are allergic to the ingredients contained in Elitan 10mg. Gastrointestinal bleeding, mechanical obstruction or gastrointestinal perforation due to increased intestinal motility when taking Elitan 10mg. Pheochromocytoma or suspected pheochromocytoma due to Elitan 10mg is associated with a risk of paroxysmal hypertensive crisis. A history of movement disorders due to sedation or metoclopramide. The patient has seizures with increasing intensity and intensity. People with Parkinson's disease. Children under 1 year of age absolutely should not be used because of the increased risk of causing extrapyramidal disorders. Patients with a history of methemoglobinemia due to metoclopramide or NADH - cytochrome b5 reductase deficiency.

3. Dosage and how to use Elitan 10mg

3.1. Dosage of Elitan 10mg can be used for intramuscular injection, slow intravenous injection over at least 3 minutes. Dosage is also different depending on the patient and the specific condition of the disease.
For adults
For the prevention of nausea and vomiting after surgery, the recommended dose is 10mg. For the dose used for cancer patients after radiation therapy, the recommended dose is 10mg, but up to 3 times a day. In case of use in patients with acute migraine with vomiting or nausea or vomiting or other causes of vomiting: The recommended dose is 10 mg/time, up to 3 times/day. Maximum recommended dose: 30mg/day or 0.5mg/kg/day. Subjects are children
Recommended dose 0.1-0.15mg/kg. The maximum dose is 0.5mg/kg/day. Maximum 3 times/day. Administer the drug intravenously. Special subjects
Elderly: Depending on the condition and monitoring liver function to consider reducing the dose once.
Patients with renal failure:
End stage (creatinine clearance ≤15ml/min), consider reducing the daily dose to 75%. In severe or moderate stage (creatinine clearance 15-60 ml/min), consider reducing dose by 50%. Hepatic impairment: Reduce dose to 50% for severe hepatic impairment.
Duration of treatment : Elitan 10mg should be administered by injection for the shortest possible time but still ensure effective treatment. Thereafter, oral or rectal administration may be indicated.
Prophylaxis of vomiting and nausea that appear late due to chemotherapy : up to 5 days. Treatment of vomiting and nausea after surgery: within 48 hours maximum. 3.2. How to use Elitan 10mg can be administered intravenously or intramuscularly. In these cases, the doctor or nurse is in charge of the operation.
3.3. Treatment of overdose In case of overdose of the indicated drug, some signs should be monitored such as:
Extrapyramidal disorders. Decreased cognitive ability, lethargy. The patient may be confused or have hallucinations. There is a risk of cardiac arrest, respiratory arrest. When extrapyramidal disorders occur, which may or may not be due to overdose, the patient should be discontinued from metoclopramide. Thereafter, symptomatic medications include benzodiazepines in children and anticholinergics for Parkinson's in adults. Cardiovascular and respiratory symptoms should be continuously monitored and treated according to the clinical characteristics of the patient. Diphenhydramine 50 mg IM or benzatropin 1-2 mg IM can be used.

4. Side effects when using Elitan 10mg

In the course of taking Elitan, some undesirable effects may occur as follows:
Signs of extrapyramidal disorders: The risk of acute dystonia or dyskinesia. Signs of parkinson's syndrome and restlessness. Drowsy state. Decreased cognitive ability, confusion and hallucinations.

5. Things to keep in mind when taking Elitan 10mg

During the use of Elitan 10mg, patients should note:
If the patient has persistent vomiting, they should be examined again to rule out the possibility of an underlying disorder such as an irritated brain. Caution should be exercised in patients being treated with drugs that act on the central nervous system such as epilepsy. Extrapyramidal symptoms may occur, which are common in children and young adults and/or in patients receiving high doses of Elitan. The interval between 2 doses should be at least 6 hours, including vomiting or not taking a full dose to avoid the risk of overdose. In case the patient has to take prolonged treatment with Elitan, it may cause tardive dyskinesia. Some of the most irreversible cases are the elderly. Therefore, it is necessary to monitor the condition and progression of the disease, and the treatment period should not be extended beyond 3 months. Elitan may worsen Parkinson's symptoms. In addition, some cases of methemoglobinemia possibly associated with NADH-cytochrome b5 reductase deficiency have been reported. When a patient has methemoglobinemia, medication and appropriate treatment measures such as methylene blue should be initiated immediately. Furthermore, Elitan 10 mg may cause serious cardiovascular reactions that have been reported after injection, especially intravenous administration including cardiac arrest and QT prolongation, circulatory collapse, and severe bradycardia. important.

6. Drug interactions

Absolutely do not combine Elitan 10mg with levodopa or dopamine agonists. Avoid combining this drug with alcohol, because alcohol increases the risk of the CNS depressant effects of metoclopramide. Anticholinergics and morphine derivatives due to their influence on gastrointestinal motility. Central analgesics including morphine derivatives, anti-anxiety drugs, H-antihistamines... increase the effect on mental health. Increased or decreased absorption of some other drugs because metoclopramide increases gastrointestinal motility. Sedatives: Elitan increases the effect of neuroleptics and causes extrapyramidal disorders. Serotonergic drugs increase the risk of serotonin syndrome. Digoxin: Increases bioavailability of Digoxin. Therefore, when used in combination, it is necessary to closely monitor plasma digoxin concentrations. Cyclosporin: Increases the bioavailability of cyclosporin. mivacurium and suxamethonium. CYP2D6 inhibitors. Patients need to keep Elitan 10mg medicine in a place away from moisture and cool. Store below 30 degrees Celsius and avoid direct sunlight. Medicines should be kept out of reach of children and pets.
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