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Egaldy drug belongs to the group of drugs used to treat eyes, ears, nose and throat. The drug is prepared for the user in the form of a solution of eye drops. So what is Egaldy and how is it used?
1. What is egaldy?
Egaldy medicine contains the main active ingredient Moxifloxacin in the form of Moxifloxacin HCl 25mg and excipients just enough for 1 tablet. The drug is packaged in the form of a box of 1 vial of 5ml.
2. Uses of Egaldy
Egaldy drug is indicated for use in the treatment of conjunctivitis caused by bacterial strains sensitive to moxifloxacin
Pharmacodynamic properties: Moxifloxacin is a broad-spectrum antibiotic with bactericidal effect. The bactericidal effect is due to the inhibition of topoisomerases II and IV, which are the main enzymes that control the topology of DNA and help with DNA replication, repair and replication.
Pharmacokinetic properties: Absorption: Moxifloxacin is well and rapidly absorbed from the gastrointestinal tract. Unaffected by feed and dairy products, absolute bioavailability is about 90%.
Distribution:
At a dose of 400 mg orally once a day, peak plasma concentrations occur after 0.5 to 4 hours. The mean trough concentration of the drug was 0.6mg/l. With tissue concentrations often exceeding those in blood, moxifloxacin is widely distributed throughout the body. The protein binding rate in the blood averages about 50% and is independent of concentration. Metabolism: Moxifloxacin is metabolised by a conjugate mode. With sulfate accounting for about 38% of the dose, is excreted mainly in the feces. Approximately 14% of an oral or intravenous dose is converted to the conjugated form of glucuronide, which is completely excreted in the urine.
Excretion: Approximately 12 hours is the plasma half-life. Approximately 45% of an oral or intravenous dose of moxifloxacin is excreted unchanged.
3. Dosage and how to use Egaldy
How to use: The drug is used by eye drops, Users screw in to create a dropper hole.
Dosage: Patients can refer to the recommended dosage as follows:
Adults and children over 1 year old: use by instilling 1 drop x 3 times/day. Symptoms will improve after 5 days, continue taking for another 2-3 days. Patients with liver failure, kidney failure: No need to change the dosage of the drug Note: Only instill in the affected eye.
4. Side effects of Egaldy
Reported ocular side effects include:
The most common adverse reactions were conjunctivitis, decreased vision, dry eye, keratitis, eye discomfort, edema, eye pain, eye itching, discharge. subconjunctival hemorrhage, and lacrimation. These reactions occur in approximately 1-6% of patients. Non-ocular adverse reactions have been reported at an incidence of 1-4% such as fever, cough, bacterial infection, otitis media, pharyngitis, erythema, and rhinitis.
5. Egaldy drug interactions
Egaldy drug interactions have not been studied with Vigamox.
Moxifloxacin does not alter drugs metabolized by cytochrome P450 isozymes because laboratory studies have shown that moxifloxacin does not inhibit CYP3A4, CYP2D6, CYP2C19, CYP1A2.
6. Some notes when using Egaldy
Egaldy should not be given to infants. Do not share the vial with many people, do not touch the dropper tip to ensure hygiene. Use at least 5 minutes after other eye drops. Hopefully, the information shared about the uses and some notes when using Egaldy will help users understand and use the drug safely.
