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Paracetamol is the most commonly used active ingredient in clinical practice with effective analgesic and antipyretic effects. There are now many preparations containing this active ingredient, including Effemax 500 in the form of effervescent tablets. So how should patients use Effemax to ensure effectiveness and safety?
1. What is Effemax 500mg?
Effemax 500 is a product of the group of pain relievers and fever reducers with the content of paracetamol 500mg. This product is manufactured by Quang Minh Pharmaceutical Trading Joint Stock Company, registration number VD-13991-11.
Effemax 500 is prepared in the form of effervescent tablets, packed in each box of 5 blisters, corresponding to each blister of 4 tablets.
2. What are the effects of Effemax 500mg?
Paracetamol (also known as Acetaminophen or N-acetyl-p-aminophenol) is an active metabolite of Phenacetin and has a very effective analgesic and antipyretic effect. Effemax 500 can replace aspirin because it has similar analgesic and antipyretic properties, but the biggest difference is that it has no anti-inflammatory effect. It should be noted that Effemax 500 reduces body temperature in febrile people, but rarely lowers body temperature in normal people. The antipyretic mechanism of Effemax 500 is acting on the hypothalamus, increasing thermogenesis due to vasodilation and increased peripheral blood flow.
Effemax 500 when used at therapeutic doses has little effect on the cardiovascular and respiratory systems, and does not change the acid - base balance, does not cause irritation, ulcers or stomach bleeding like when salicylates due to active ingredients Paracetamol has no effect on systemic cyclooxygenase fermentation, but only affects cyclooxygenase/prostaglandin of the central nervous system. In addition, the active ingredient paracetamol in Effemax 500 has no impact on platelet function or bleeding time.
Every pharmaceutical product works to treat a specific disease or condition and Effemax 500 is no exception. Therefore, patients should only use Effemax 500 for the treatment of diseases or conditions specified in the instructions for use of the drug. Although this product can be used to treat some problems that are not mentioned in the instructions for use, however, in this case, the patient should not use it on his own but must be prescribed by a doctor.
3. Indications and contraindications of Effemax 500
The active ingredient paracetamol is commonly used in the treatment of mild to moderate pain and fever, specifically as follows:
Pain relief: Effemax 500 is used for the purpose of temporary pain relief in mild pain conditions. to moderate pain such as headache, toothache, dysmenorrhea... Effemax 500 is most effective in relieving low-intensity pain of non-visceral origin. Note that Paracetamol has no effect on rheumatism and can be substituted for salicylates (in people with contraindications or intolerance to salicylates) to relieve mild pain or reduce fever; Antipyretic: Effemax 500 has the ability to effectively reduce fever, but does not affect the course of the cause of the fever and sometimes unintentionally masks the patient's symptoms. In addition, the drug Effemax 500 has the following contraindications:
Patients with anemia repeatedly or with heart, lung, kidney, or liver disease; People who are hypersensitive to paracetamol; People with glucose - 6 - phosphate dehydrogenase (G6PD) deficiency.
4. Instructions for using Effemax 500
Patients need to carefully read the instructions for use of Effemax 500 on the package or accompanying instructions for use before using, do not arbitrarily use other drugs with the accompanying information. This product is for oral use. However, patients should not take Effemax 500 for pain relief for more than 10 days in adults or 5 days in children, unless directed by a doctor because severe and prolonged pain can be a sign of A disease that needs to be diagnosed and treated under the supervision of a doctor. In addition, patients should also not use Effemax 500 for high fever above 39.5 degrees Celsius, fever lasting more than 3 days or recurrent fever (unless prescribed by a doctor), because such fever may be suggestive of symptoms. Note a serious illness that needs to be diagnosed early by a doctor.
To limit the risk of overdose, Effemax 500 should not be used in children more than 5 doses in 24 hours, unless directed by a doctor. For the purpose of pain relief or fever reduction in adults and children over 11 years of age, the usual dose of Paracetamol is 325 - 650mg, administered every 4-6 hours as needed but not exceeding 4g a day. In some cases, a single use of more than 1g of paracetamol (2 Effemax 500 tablets) can provide more effective pain relief.
For children, analgesic or antipyretic dose of paracetamol orally or rectally every 4-6 hours depending on age:
Children 1 - 2 years old: 120mg; Children 4 - 11 months old: 80mg; Children under 3 months old: 40mg. Some notes about the dosage of Effemax 500:
The dosing instructions are usually for adults taking orally. For other routes of administration, the dosage may vary and is usually mentioned in the instructions for use. Patients absolutely do not arbitrarily change the dose of Effemax 500 without consulting the doctor, pharmacist; When using Effemax 500 for children, it should be noted that there are differences in pharmacokinetics, pharmacodynamics, side effects... compared to adults. In particular, this subject is not allowed to conduct clinical trials before licensing the drug, so it is necessary to be very careful even with drugs that have not been warned.
5. Precautions and notes when using Effemax
The active ingredient Paracetamol in Effemax 500 is relatively benign when used at the recommended therapeutic dose. Occasionally, users of Effemax 500 have experienced skin reactions such as pruritic maculopapular rash, urticaria, other hypersensitivity reactions (including laryngeal edema, angioedema) and anaphylactoid reactions, however the incidence is high. is very low.
A decrease in the number of blood cells such as platelets, white blood cells or total blood cells has occurred with the use of P-aminophenol derivatives, especially when used in high doses for a long time. Decreased neutrophil counts and thrombocytopenic purpura have occurred with paracetamol use.
Effemax 500 should be used with caution in patients with pre-existing anemia, as cyanosis may not be evident despite sufficiently high blood levels of methemoglobin.
Heavy use of alcohol is a factor that increases the hepatotoxicity of Effemax 500, so it is necessary to stop or limit alcohol consumption.
Women who are pregnant should only use preparations containing Paracetamol (such as Effemax) when absolutely necessary.
Paracetamol can be passed to babies through breastfeeding in mothers who use Effemax 500. So to ensure safety, breastfeeding mothers should not or limit the use of drugs, including Effemax 500.
6. Side effects of Effemax 500
Skin rashes and other allergic reactions sometimes occur, most commonly erythema or urticaria but sometimes more severe, accompanied by drug fever and mucosal lesions; A small number of isolated cases of Paracetamol use resulted in a decrease in neutrophil counts, thrombocytopenia or a total decrease in platelets; Nausea, vomiting; Anemia; Kidney disease or nephrotoxicity with long-term abuse. The above note may not be a list of all the side effects of Effemax 500. In the process of using the drug and the occurrence of other side effects that have not been shown or have not been studied, please consult patients. consult your doctor or pharmacist.
7. Drug interactions of Effemax 500
Long-term use with high doses of Effemax may slightly increase the anticoagulant effect of Coumarin and Indandion derivatives. However, this interaction seems to be of little or no clinical importance, so Effemax 500 is preferred over salicylates when mild pain relief or fever is needed in patients taking Coumarin or Indandion derivatives.
Effemax 500 may cause severe hypothermia in patients receiving concomitant phenothiazines and other hypothermia therapies.
Excessive and long-term alcohol consumption can increase the risk of hepatotoxicity of Effemax 500.
Anticonvulsants (including Phenytoin, Barbiturates, Carbamazepine) induce liver microsomal enzymes, so may increases the hepatotoxicity of Effemax 500 by increasing the metabolism of the drug into substances that are toxic to the liver.
Concomitant use of Isoniazid with Effemax 500 may lead to an increased risk of hepatotoxicity, but the exact mechanism of this interaction is unknown.
When using Effemax 500 with foods or alcohol, beer, tobacco... because the above products may include many different active ingredients, the possibility of drug interactions can completely occur. . Patients need to carefully read the instructions for use of the drug or consult a doctor or pharmacist about taking Effemax 500 with food, alcohol and tobacco.
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