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Efavirenz 600 contains the main active ingredient, Efavirenz 600mg, manufactured by Ampharco Pharmaceutical Joint Stock Company U.S.A. Efavirenz is an antiviral medicine that prevents HIV, a human immunodeficiency virus, from replicating in the body.
1. What is Efavirenz?
Efavirenz 600mg medicine contains the active ingredient Efavirenz 600mg, is made in the form of film-coated tablets. Efavirenz is an antiretroviral medication that prevents HIV, a human immunodeficiency virus, from replicating in the body.
2. Uses of Efavirenz 600
Efavirenz 600 is indicated in the following cases:
Used to treat HIV-1 when combined with other antiretroviral drugs (HIV - the virus can cause acquired immunodeficiency syndrome called acquired immunodeficiency syndrome). AIDS). Efavirenz is intended for adults and children who are at least 3 months old and weigh at least 3.6 kilograms. In case of occupational or non-occupational HIV exposure, Efavirenz (in combination with 2 other nucleosides) can be used for prevention. Note: Efavirenz 600mg is not a cure for HIV or AIDS.
3. How to use Efavirenz to be effective?
Efavirenz must be used in combination with other antiviral drugs and should not be used alone. If you do not take Efavirenz in combination with other HIV medicines that your doctor has prescribed, it may lead to resistance to Efavirenz. Patients should take Efavirenz on an empty stomach before going to bed. Swallow the Efavirenz tablet whole with a glass of water and do not crush, chew, or break the tablet. If you cannot swallow the capsule whole, open it and sprinkle the medicine with a spoonful of apple sauce, yogurt, grape jelly, or infant formula (if you are using Efavirenz for young children). Swallow the mixture immediately, do not leave the mixed mixture for later use. Do not eat for the next 2 hours after taking Efavirenz by the sprinkle method. If you give your baby Efavirenz mixed with formula, then for at least 2 hours do not give your baby any more formula. The dose of Efavirenz used in children depends on weight. Dosage requirements for children may change if the child gains or loses weight.
During the use of drugs for treatment, regular medical check-ups are required.
Take Efavirenz regularly and at the right dose for effective treatment. Missing or missing doses can increase the risk of antiviral resistance.
Store Efavirenz at room temperature away from moisture and heat.
Efavirenz may interfere with a drug screening urine test and you may get false results. Tell the testing staff that you use Efavirenz.
Take all HIV medications as directed and read all medication instructions given to you by your healthcare provider. Do not change the dose or duration of Efavirenz without your doctor's advice. Every person with HIV should be under the care of a doctor.
4. Dosage of Efavirenz
4.1. Usual Adult Dose for HIV Infection 600mg once daily. Efavirenz should be used with protease inhibitors and/or NRTIs. Use: treatment of HIV-1 infection in combination with other antiretroviral agents. 4.2. Usual Adult Dose for Incidental Exposure US CDC Recommendations: Oral 600mg once daily Duration of Treatment: 28 days Efavirenz should be used with (Lamivudine or Emtricitabine) plus (Zidovudine or Tenofovir ); is recommended as the preferred NNRTI-based regimen for the prophylaxis of HIV infection after non-thoracic exposure. Within 72 hours of exposure, prophylaxis should be initiated as soon as possible. Not approved by the US FDA. 4.3. Usual Adult Dose for Occupational Exposure 600mg once daily. Treat for 28 days, if tolerated. Prophylactic treatment should begin as soon as possible, preferably within a few hours of exposure. The optimal duration of treatment has not been determined and may vary depending on the facility's protocol. Not approved by the US FDA. 4.4. Usual Pediatric Dose for HIV Infection Use with children 3 months of age and older:
From 3.5kg to under 5kg: 100mg/time/day. From 5kg to less than 7.5kg: 150mg/time/day. From 7.5kg to under 15kg: 200mg/time/day. From 15kg to less than 20kg: 250mg/time/day. From 20kg to under 25kg: 300mg/time/day. From 25kg to under 32.5kg: take 350mg/time/day. From 32.5kg to less than 40kg: 400mg/time/day. From 40kg or more: 600mg/time/day. Use: treatment of HIV-1 infection in combination with other antiretroviral agents.
4.5. Overdosage of Efavirenz 600 Several patients inadvertently taking 600 mg twice daily have reported increased nervous system symptoms, one patient had involuntary muscle cramps.
Treatment of Efavirenz overdose should include general supportive measures, including monitoring of vital signs and monitoring of the patient's clinical condition. Activated charcoal can be used to aid in the elimination of unabsorbed Efavirenz. There is no specific antidote for overdose with Efavirenz. Because Efavirenz is highly protein bound, dialysis is unlikely to remove significant amounts of it from the blood.
5. What are the side effects of using Efavirenz?
If signs of an allergic reaction (rash, difficulty breathing, swelling in the face or throat) or severe skin reaction (fever, sore throat, skin pain, burning eyes, red skin rash or purple with blistering and peeling). Immediately contact a medical center for supportive care and treatment.
Effects on the nervous system: hallucinations, trouble concentrating, trouble speaking or moving (these symptoms can occur months or years after you start taking Efavirenz), headache, dizziness, sadness sleep, confusion, trouble concentrating, strange dreams, insomnia, or problems with voice, balance, or muscle movement.
Effects on the liver: nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Effects on the immune system (even weeks or months after you take Efavirenz): signs of a new infection - fever, night sweats, swollen glands, cough, wheezing, slump weight, diarrhea.
Other side effects: changes in the shape or location of body fat (especially in your arms, legs, face, neck, chest, and waist), swelling in your neck or throat (thyroid glands) enlargement), menstrual changes, impotence, . ..
6. What should be noted before using Efavirenz 600?
Do not use Efavirenz 600 if you are allergic to the active ingredient Efavirenz or any of its excipients. If you are using Elbasvir and Grazoprevir (Zepatier) to treat hepatitis C, do not use Efavirenz 600. Do not use with Atripla, which is a combination of Efavirenz, Emtricitabine and Tenofovir, unless your doctor tells you to. bridge. If you have a history of the following conditions, tell your treating doctor: liver disease (including hepatitis B or C), long QT syndrome, epilepsy, mental illness or psychosis , heart disease, or if you drink large amounts of alcohol or have a history of injectable drug use. Absolutely do not use Efavirenz if you are pregnant. Because Efavirenz can harm an unborn baby or cause birth defects. During the use of Efavirenz, you can use 2 forms of contraception, including mechanical contraception (condom, diaphragm, cervical cap, ...) to prevent pregnancy and at least 12 weeks after the last dose. your same. If you become pregnant during treatment, tell your treating doctor. Hormonal birth control (injections, birth control pills, vaginal rings, implants, and skin patches) may not be effective enough to prevent pregnancy while you are taking Efavirenz. HIV can be passed from mother to baby if the virus is not controlled during pregnancy. Don't breastfeed if you have HIV or AIDS. Even if your baby is born without HIV, the virus can be passed on to your baby in your breast milk. Using Efavirenz will not prevent infection, so do not have unprotected sex, share razors, toothbrushes, or needles. Efavirenz 600 contains the active ingredient Efavirenz 600mg. This is an antiretroviral drug that prevents HIV, a human immunodeficiency virus, from replicating in the body. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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